The application of Fourier Transform infrared (FTIR) imaging using the macro attenuated total reflection (ATR)-IR methodology to formulations of ibuprofen in poly(ethylene glycol) (PEG) enabled characterization of the distribution of both, polymer and drug, in the tablet. Visualization of the dissolution process upon contact of the tablet with flowing water has been demonstrated. The mechanism of dissolution and drug release for two tablet preparation methods (mechanical mixing and melt) have been compared using this spectroscopic imaging approach.