Distinct blood protein markers are associated with brain regions of early amyloid deposition in Alzheimer's disease

Nicholas Ashton; Steven J Kiddle; Lennart Thurfjell; John Graf; Malcolm Ward; Alison L Baird; Abdul Hye; Richard J Dobson; Andrew Torres; Zhanpan Zhang

doi:10.1016/j.jalz.2014.05.404

Distinct blood protein markers are associated with brain regions of early amyloid deposition in Alzheimer's disease

Nicholas Ashton, Steven J Kiddle, Lennart Thurfjell, John Graf, Malcolm Ward, Alison L Baird, Abdul Hye, Richard J Dobson, Andrew Torres, Zhanpan Zhang

Research output: Contribution to journal › Meeting abstract › peer-review

Abstract

A key pathological hallmark of Alzheimer's disease (AD) is the deposition of b -amyloid in the brain. There is a strong association between brain amyloid burden and the risk of developing AD-like pathology. Imaging using markers of b -amyloid combined with Positron Emission Tomography (PET) allows a semi-quantitative in vivo assessment of A b depostion in the subject brains. However, this approach is invasive, costly and restricted to specialised centres. Candidate blood protein biomarkers that predicted global neocortical brain amyloid load have been recently identified (our group and Burnham et al.

Original language	Undefined/Unknown
Article number	P1-166
Pages (from-to)	P360-P361
Journal	Alzheimer's & dementia : the journal of the Alzheimer's Association
Volume	10
Issue number	4 Supplement
DOIs	https://doi.org/10.1016/j.jalz.2014.05.404
Publication status	Published - 1 Jul 2014

Access to Document

10.1016/j.jalz.2014.05.404

Cite this

Ashton, N., Kiddle, S. J., Thurfjell, L., Graf, J., Ward, M., Baird, A. L., Hye, A., Dobson, R. J., Torres, A., & Zhang, Z. (2014). Distinct blood protein markers are associated with brain regions of early amyloid deposition in Alzheimer's disease. Alzheimer's & dementia : the journal of the Alzheimer's Association, 10(4 Supplement), P360-P361. Article P1-166. https://doi.org/10.1016/j.jalz.2014.05.404

@article{d6f852f0ce1a4a3b84fedd4e26491d2f,

title = "Distinct blood protein markers are associated with brain regions of early amyloid deposition in Alzheimer's disease",

abstract = "A key pathological hallmark of Alzheimer's disease (AD) is the deposition of b -amyloid in the brain. There is a strong association between brain amyloid burden and the risk of developing AD-like pathology. Imaging using markers of b -amyloid combined with Positron Emission Tomography (PET) allows a semi-quantitative in vivo assessment of A b depostion in the subject brains. However, this approach is invasive, costly and restricted to specialised centres. Candidate blood protein biomarkers that predicted global neocortical brain amyloid load have been recently identified (our group and Burnham et al.",

author = "Nicholas Ashton and Kiddle, {Steven J} and Lennart Thurfjell and John Graf and Malcolm Ward and Baird, {Alison L} and Abdul Hye and Dobson, {Richard J} and Andrew Torres and Zhanpan Zhang",

note = "{\textcopyright} 2014 Published by Elsevier Inc.",

year = "2014",

month = jul,

day = "1",

doi = "10.1016/j.jalz.2014.05.404",

language = "Undefined/Unknown",

volume = "10",

pages = "P360--P361",

journal = "Alzheimer's & dementia : the journal of the Alzheimer's Association",

issn = "1552-5279",

publisher = "Wiley",

number = "4 Supplement",

}

Ashton, N , Kiddle, SJ, Thurfjell, L, Graf, J, Ward, M , Baird, AL , Hye, A , Dobson, RJ, Torres, A & Zhang, Z 2014, 'Distinct blood protein markers are associated with brain regions of early amyloid deposition in Alzheimer's disease', Alzheimer's & dementia : the journal of the Alzheimer's Association, vol. 10, no. 4 Supplement, P1-166, pp. P360-P361. https://doi.org/10.1016/j.jalz.2014.05.404

Distinct blood protein markers are associated with brain regions of early amyloid deposition in Alzheimer's disease. / Ashton, Nicholas ; Kiddle, Steven J; Thurfjell, Lennart et al.
In: Alzheimer's & dementia : the journal of the Alzheimer's Association, Vol. 10, No. 4 Supplement, P1-166, 01.07.2014, p. P360-P361.

Research output: Contribution to journal › Meeting abstract › peer-review

TY - JOUR

T1 - Distinct blood protein markers are associated with brain regions of early amyloid deposition in Alzheimer's disease

AU - Ashton, Nicholas

AU - Kiddle, Steven J

AU - Thurfjell, Lennart

AU - Graf, John

AU - Ward, Malcolm

AU - Baird, Alison L

AU - Hye, Abdul

AU - Dobson, Richard J

AU - Torres, Andrew

AU - Zhang, Zhanpan

PY - 2014/7/1

Y1 - 2014/7/1

N2 - A key pathological hallmark of Alzheimer's disease (AD) is the deposition of b -amyloid in the brain. There is a strong association between brain amyloid burden and the risk of developing AD-like pathology. Imaging using markers of b -amyloid combined with Positron Emission Tomography (PET) allows a semi-quantitative in vivo assessment of A b depostion in the subject brains. However, this approach is invasive, costly and restricted to specialised centres. Candidate blood protein biomarkers that predicted global neocortical brain amyloid load have been recently identified (our group and Burnham et al.

AB - A key pathological hallmark of Alzheimer's disease (AD) is the deposition of b -amyloid in the brain. There is a strong association between brain amyloid burden and the risk of developing AD-like pathology. Imaging using markers of b -amyloid combined with Positron Emission Tomography (PET) allows a semi-quantitative in vivo assessment of A b depostion in the subject brains. However, this approach is invasive, costly and restricted to specialised centres. Candidate blood protein biomarkers that predicted global neocortical brain amyloid load have been recently identified (our group and Burnham et al.

U2 - 10.1016/j.jalz.2014.05.404

DO - 10.1016/j.jalz.2014.05.404

M3 - Meeting abstract

SN - 1552-5279

VL - 10

SP - P360-P361

JO - Alzheimer's & dementia : the journal of the Alzheimer's Association

JF - Alzheimer's & dementia : the journal of the Alzheimer's Association

IS - 4 Supplement

M1 - P1-166

ER -