Distinct blood protein markers are associated with brain regions of early amyloid deposition in Alzheimer's disease

Nicholas Ashton, Steven J Kiddle, Lennart Thurfjell, John Graf, Malcolm Ward, Alison L Baird, Abdul Hye, Richard J Dobson, Andrew Torres, Zhanpan Zhang

Research output: Contribution to journalMeeting abstractpeer-review


A key pathological hallmark of Alzheimer's disease (AD) is the deposition of b -amyloid in the brain. There is a strong association between brain amyloid burden and the risk of developing AD-like pathology. Imaging using markers of b -amyloid combined with Positron Emission Tomography (PET) allows a semi-quantitative in vivo assessment of A b depostion in the subject brains. However, this approach is invasive, costly and restricted to specialised centres. Candidate blood protein biomarkers that predicted global neocortical brain amyloid load have been recently identified (our group and Burnham et al.
Original languageUndefined/Unknown
Article numberP1-166
Pages (from-to)P360-P361
JournalAlzheimer's & dementia : the journal of the Alzheimer's Association
Issue number4 Supplement
Publication statusPublished - 1 Jul 2014

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