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Distinct learning-induced changes in stimulus selectivity and interactions of GABAergic interneuron classes in visual cortex

Research output: Contribution to journalArticle

Adil G Khan, Jasper Poort, Angus Chadwick, Antonin Blot, Maneesh Sahani, Thomas D Mrsic-Flogel, Sonja B Hofer

Original languageEnglish
Pages (from-to)851-859
Number of pages9
JournalNature Neuroscience
Volume21
Issue number6
Early online date21 May 2018
DOIs
Publication statusE-pub ahead of print - 21 May 2018

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Abstract

How learning enhances neural representations for behaviorally relevant stimuli via activity changes of cortical cell types remains unclear. We simultaneously imaged responses of pyramidal cells (PYR) along with parvalbumin (PV), somatostatin (SOM), and vasoactive intestinal peptide (VIP) inhibitory interneurons in primary visual cortex while mice learned to discriminate visual patterns. Learning increased selectivity for task-relevant stimuli of PYR, PV and SOM subsets but not VIP cells. Strikingly, PV neurons became as selective as PYR cells, and their functional interactions reorganized, leading to the emergence of stimulus-selective PYR-PV ensembles. Conversely, SOM activity became strongly decorrelated from the network, and PYR-SOM coupling before learning predicted selectivity increases in individual PYR cells. Thus, learning differentially shapes the activity and interactions of multiple cell classes: while SOM inhibition may gate selectivity changes, PV interneurons become recruited into stimulus-specific ensembles and provide more selective inhibition as the network becomes better at discriminating behaviorally relevant stimuli.

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