Distinct molecular programs regulate synapse specificity in cortical inhibitory circuits

Emilia Favuzzi; Rubén Deogracias; André Marques-Smith; Patricia Maeso; Julie Jezequel; David Exposito-Alonso; Maddalena Balia; Tim Kroon; Antonio J. Hinojosa; Elisa F. Maraver; Beatriz Rico

doi:10.1126/science.aau8977

Distinct molecular programs regulate synapse specificity in cortical inhibitory circuits

Emilia Favuzzi, Rubén Deogracias, André Marques-Smith, Patricia Maeso, Julie Jezequel, David Exposito-Alonso, Maddalena Balia, Tim Kroon, Antonio J. Hinojosa, Elisa F. Maraver, Beatriz Rico^*

^*Corresponding author for this work

Developmental Neurobiology

CSIC & Universidad Miguel Hernández

Research output: Contribution to journal › Article › peer-review

121 Citations (Scopus)

90 Downloads (Pure)

Abstract

How neuronal connections are established and organized into functional networks determines brain function. In the mammalian cerebral cortex, different classes of GABAergic interneurons exhibit specific connectivity patterns that underlie their ability to shape temporal dynamics and information processing. Much progress has been made toward parsing interneuron diversity, yet the molecular mechanisms by which interneuron-specific connectivity motifs emerge remain unclear. In this study, we investigated transcriptional dynamics in different classes of interneurons during the formation of cortical inhibitory circuits in mouse. We found that whether interneurons form synapses on the dendrites, soma, or axon initial segment of pyramidal cells is determined by synaptic molecules that are expressed in a subtype-specific manner. Thus, cell-specific molecular programs that unfold during early postnatal development underlie the connectivity patterns of cortical interneurons.

Original language	English
Pages (from-to)	413-417
Number of pages	5
Journal	Science
Volume	363
Issue number	6425
Early online date	25 Jan 2019
DOIs	https://doi.org/10.1126/science.aau8977
Publication status	Published - 25 Jan 2019

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Distinct molecular programs regulate synapse_RICO_Publishedonline25January2019_GREEN AAMAccepted author manuscript, 6.33 MB

https://discovery.ucl.ac.uk/id/eprint/10066873/

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title = "Distinct molecular programs regulate synapse specificity in cortical inhibitory circuits",

abstract = "How neuronal connections are established and organized into functional networks determines brain function. In the mammalian cerebral cortex, different classes of GABAergic interneurons exhibit specific connectivity patterns that underlie their ability to shape temporal dynamics and information processing. Much progress has been made toward parsing interneuron diversity, yet the molecular mechanisms by which interneuron-specific connectivity motifs emerge remain unclear. In this study, we investigated transcriptional dynamics in different classes of interneurons during the formation of cortical inhibitory circuits in mouse. We found that whether interneurons form synapses on the dendrites, soma, or axon initial segment of pyramidal cells is determined by synaptic molecules that are expressed in a subtype-specific manner. Thus, cell-specific molecular programs that unfold during early postnatal development underlie the connectivity patterns of cortical interneurons.",

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AU - Favuzzi, Emilia

AU - Deogracias, Rubén

AU - Marques-Smith, André

AU - Maeso, Patricia

AU - Jezequel, Julie

AU - Exposito-Alonso, David

AU - Balia, Maddalena

AU - Kroon, Tim

AU - Hinojosa, Antonio J.

AU - Maraver, Elisa F.

AU - Rico, Beatriz

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AB - How neuronal connections are established and organized into functional networks determines brain function. In the mammalian cerebral cortex, different classes of GABAergic interneurons exhibit specific connectivity patterns that underlie their ability to shape temporal dynamics and information processing. Much progress has been made toward parsing interneuron diversity, yet the molecular mechanisms by which interneuron-specific connectivity motifs emerge remain unclear. In this study, we investigated transcriptional dynamics in different classes of interneurons during the formation of cortical inhibitory circuits in mouse. We found that whether interneurons form synapses on the dendrites, soma, or axon initial segment of pyramidal cells is determined by synaptic molecules that are expressed in a subtype-specific manner. Thus, cell-specific molecular programs that unfold during early postnatal development underlie the connectivity patterns of cortical interneurons.

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Distinct molecular programs regulate synapse specificity in cortical inhibitory circuits

Abstract

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