Distinct neurodevelopmental trajectories in groups of very preterm children screening positively for autism spectrum conditions: Autism screening preterm subgroups

Laila Hadaya; Lucy Vanes; Vyacheslav R Karolis; Dana Kanel; Marguerite Leoni; Francesca Happe; David Edwards; Serena Counsell; Dafnis Batalle; Chiara Nosarti

doi:https://doi.org/10.1007/s10803-022-05789-4

Distinct neurodevelopmental trajectories in groups of very preterm children screening positively for autism spectrum conditions: Autism screening preterm subgroups

Laila Hadaya, Lucy Vanes, Vyacheslav R Karolis, Dana Kanel, Marguerite Leoni, Francesca Happe, David Edwards, Serena Counsell, Dafnis Batalle, Chiara Nosarti^*

^*Corresponding author for this work

King's College London

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Abstract

Very preterm (VPT; < 33 weeks’ gestation) toddlers screening positively for autism spectrum conditions (ASC) may display heterogenous neurodevelopmental trajectories. Here we studied neonatal brain volumes and childhood ASC traits evaluated with the Social Responsiveness Scale (SRS-2) in VPT-born toddlers (N = 371; median age 20.17 months) sub-divided into three groups based on their Modified-Checklist for Autism in Toddlers scores. These were: those screening positively failing at least 2 critical items (critical-positive); failing any 3 items, but less than 2 critical items (non-critical-positive); and screening negatively. Critical-positive scorers had smaller neonatal cerebellar volumes compared to non-critical-positive and negative scorers. However, both positive screening groups exhibited higher childhood ASC traits compared to the negative screening group, suggesting distinct aetiological trajectories associated with ASC outcomes.

Original language	English
Journal	Journal of Autism and Developmental Disorders
DOIs	https://doi.org/10.1007/s10803-022-05789-4
Publication status	Published - 24 Oct 2022

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https://doi.org/10.1007/s10803-022-05789-4Licence: CC BY

2022_08_Hadaya_JAutDevDisFinal published version, 1.44 MBLicence: CC BY

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Hadaya, L., Vanes, L., Karolis, V. R., Kanel, D., Leoni, M., Happe, F., Edwards, D., Counsell, S., Batalle, D., & Nosarti, C. (2022). Distinct neurodevelopmental trajectories in groups of very preterm children screening positively for autism spectrum conditions: Autism screening preterm subgroups. Journal of Autism and Developmental Disorders. https://doi.org/10.1007/s10803-022-05789-4

@article{85ece9e7406649119186784128e00912,

title = "Distinct neurodevelopmental trajectories in groups of very preterm children screening positively for autism spectrum conditions: Autism screening preterm subgroups",

abstract = "Very preterm (VPT; < 33 weeks{\textquoteright} gestation) toddlers screening positively for autism spectrum conditions (ASC) may display heterogenous neurodevelopmental trajectories. Here we studied neonatal brain volumes and childhood ASC traits evaluated with the Social Responsiveness Scale (SRS-2) in VPT-born toddlers (N = 371; median age 20.17 months) sub-divided into three groups based on their Modified-Checklist for Autism in Toddlers scores. These were: those screening positively failing at least 2 critical items (critical-positive); failing any 3 items, but less than 2 critical items (non-critical-positive); and screening negatively. Critical-positive scorers had smaller neonatal cerebellar volumes compared to non-critical-positive and negative scorers. However, both positive screening groups exhibited higher childhood ASC traits compared to the negative screening group, suggesting distinct aetiological trajectories associated with ASC outcomes.",

author = "Laila Hadaya and Lucy Vanes and Karolis, {Vyacheslav R} and Dana Kanel and Marguerite Leoni and Francesca Happe and David Edwards and Serena Counsell and Dafnis Batalle and Chiara Nosarti",

note = "Funding Information: This work was financially supported by: The Medical Research Council, UK [Grant numbers: MR/K006355/1 and MR/S026460/1] and Action Medical Research and Dangoor Education [Grant number: GN2606]. Data analysed in this study was collected during independent research funded by the National Institute for Health Research (NIHR) Programme Grants for Applied Research Programme [Grant number: RP-PG-0707-10154] and supported by NIHR Biomedical Research Centre, Guy{\textquoteright}s and St Thomas{\textquoteright} NHS Foundation Trust and King{\textquoteright}s College London, the NIHR Clinical Research Facility, Guy{\textquoteright}s and St Thomas{\textquoteright} and the MRC Centre for Neurodevelopmental Disorders. Publisher Copyright: {\textcopyright} 2022, The Author(s).",

year = "2022",

month = oct,

day = "24",

doi = "https://doi.org/10.1007/s10803-022-05789-4",

language = "English",

journal = "Journal of Autism and Developmental Disorders",

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Hadaya, L , Vanes, L, Karolis, VR, Kanel, D , Leoni, M , Happe, F , Edwards, D , Counsell, S , Batalle, D & Nosarti, C 2022, 'Distinct neurodevelopmental trajectories in groups of very preterm children screening positively for autism spectrum conditions: Autism screening preterm subgroups', Journal of Autism and Developmental Disorders. https://doi.org/10.1007/s10803-022-05789-4

TY - JOUR

T1 - Distinct neurodevelopmental trajectories in groups of very preterm children screening positively for autism spectrum conditions

T2 - Autism screening preterm subgroups

AU - Hadaya, Laila

AU - Vanes, Lucy

AU - Karolis, Vyacheslav R

AU - Kanel, Dana

AU - Leoni, Marguerite

AU - Happe, Francesca

AU - Edwards, David

AU - Counsell, Serena

AU - Batalle, Dafnis

AU - Nosarti, Chiara

N1 - Funding Information: This work was financially supported by: The Medical Research Council, UK [Grant numbers: MR/K006355/1 and MR/S026460/1] and Action Medical Research and Dangoor Education [Grant number: GN2606]. Data analysed in this study was collected during independent research funded by the National Institute for Health Research (NIHR) Programme Grants for Applied Research Programme [Grant number: RP-PG-0707-10154] and supported by NIHR Biomedical Research Centre, Guy’s and St Thomas’ NHS Foundation Trust and King’s College London, the NIHR Clinical Research Facility, Guy’s and St Thomas’ and the MRC Centre for Neurodevelopmental Disorders. Publisher Copyright: © 2022, The Author(s).

PY - 2022/10/24

Y1 - 2022/10/24

N2 - Very preterm (VPT; < 33 weeks’ gestation) toddlers screening positively for autism spectrum conditions (ASC) may display heterogenous neurodevelopmental trajectories. Here we studied neonatal brain volumes and childhood ASC traits evaluated with the Social Responsiveness Scale (SRS-2) in VPT-born toddlers (N = 371; median age 20.17 months) sub-divided into three groups based on their Modified-Checklist for Autism in Toddlers scores. These were: those screening positively failing at least 2 critical items (critical-positive); failing any 3 items, but less than 2 critical items (non-critical-positive); and screening negatively. Critical-positive scorers had smaller neonatal cerebellar volumes compared to non-critical-positive and negative scorers. However, both positive screening groups exhibited higher childhood ASC traits compared to the negative screening group, suggesting distinct aetiological trajectories associated with ASC outcomes.

AB - Very preterm (VPT; < 33 weeks’ gestation) toddlers screening positively for autism spectrum conditions (ASC) may display heterogenous neurodevelopmental trajectories. Here we studied neonatal brain volumes and childhood ASC traits evaluated with the Social Responsiveness Scale (SRS-2) in VPT-born toddlers (N = 371; median age 20.17 months) sub-divided into three groups based on their Modified-Checklist for Autism in Toddlers scores. These were: those screening positively failing at least 2 critical items (critical-positive); failing any 3 items, but less than 2 critical items (non-critical-positive); and screening negatively. Critical-positive scorers had smaller neonatal cerebellar volumes compared to non-critical-positive and negative scorers. However, both positive screening groups exhibited higher childhood ASC traits compared to the negative screening group, suggesting distinct aetiological trajectories associated with ASC outcomes.

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U2 - https://doi.org/10.1007/s10803-022-05789-4

DO - https://doi.org/10.1007/s10803-022-05789-4

M3 - Article

SN - 0162-3257

JO - Journal of Autism and Developmental Disorders

JF - Journal of Autism and Developmental Disorders

ER -

Distinct neurodevelopmental trajectories in groups of very preterm children screening positively for autism spectrum conditions: Autism screening preterm subgroups

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