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Distribution patterns of tau pathology in progressive supranuclear palsy

Research output: Contribution to journalArticle

Gabor G. Kovacs, Milica Jecmenica Lukic, David J. Irwin, Thomas Arzberger, Gesine Respondek, Edward B. Lee, David Coughlin, Armin Giese, Murray Grossman, Carolin Kurz, Corey T. McMillan, Ellen Gelpi, Yaroslau Compta, John C. van Swieten, Laura Donker Laat, Claire Troakes, Safa Al-Sarraj, John L. Robinson, Sigrun Roeber, Sharon X. Xie & 3 more Virginia M.Y. Lee, John Q. Trojanowski, Günter U. Höglinger

Original languageEnglish
Pages (from-to)99-119
Number of pages21
JournalActa Neuropathologica
Volume140
Issue number2
DOIs
Published1 Aug 2020

King's Authors

Abstract

Progressive supranuclear palsy (PSP) is a 4R-tauopathy predominated by subcortical pathology in neurons, astrocytes, and oligodendroglia associated with various clinical phenotypes. In the present international study, we addressed the question of whether or not sequential distribution patterns can be recognized for PSP pathology. We evaluated heat maps and distribution patterns of neuronal, astroglial, and oligodendroglial tau pathologies and their combinations in different clinical subtypes of PSP in postmortem brains. We used conditional probability and logistic regression to model the sequential distribution of tau pathologies across different brain regions. Tau pathology uniformly predominates in the neurons of the pallido-nigro-luysian axis in different clinical subtypes. However, clinical subtypes are distinguished not only by total tau load but rather cell-type (neuronal versus glial) specific vulnerability patterns of brain regions suggesting distinct dynamics or circuit-specific segregation of propagation of tau pathologies. For Richardson syndrome (n = 81) we recognize six sequential steps of involvement of brain regions by the combination of cellular tau pathologies. This is translated to six stages for the practical neuropathological diagnosis by the evaluation of the subthalamic nucleus, globus pallidus, striatum, cerebellum with dentate nucleus, and frontal and occipital cortices. This system can be applied to further clinical subtypes by emphasizing whether they show caudal (cerebellum/dentate nucleus) or rostral (cortical) predominant, or both types of pattern. Defining cell-specific stages of tau pathology helps to identify preclinical or early-stage cases for the better understanding of early pathogenic events, has implications for understanding the clinical subtype-specific dynamics of disease-propagation, and informs tau-neuroimaging on distribution patterns.

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