Disturbed flow-enhanced endothelial turnover in atherosclerosis

Qingbo Xu

doi:10.1016/j.tcm.2009.12.002

Disturbed flow-enhanced endothelial turnover in atherosclerosis

Qingbo Xu

Cardiovascular Sciences

Research output: Contribution to journal › Literature review › peer-review

31 Citations (Scopus)

Abstract

Endothelial dysfunction/death is an initial event for the development of atherosclerosis occurring in the areas of arteries where blood flow is disturbed. Recent data indicated that rapid turnover of endothelial cells in atherosclerosis-prone areas is followed by endothelial repair. The mechanisms of endothelial death/proliferation in these areas related to altered blood flow involve different signal pathways, for example, endoplasmic reticulum stress-X-box binding protein 1-caspase for apoptosis and vascular endothelial growth factor receptor-hi stone deacetylase 3-Akt for the survival. The present review aims to update the progress in endothelial turnover in response to disturbed flow and to discuss the underlining mechanisms in the development of atherosclerosis. (Trends Cardiovasc Med 2009;19:191-195) (C) 2009, Elsevier Inc.

Original language	English
Pages (from-to)	191 - 195
Number of pages	5
Journal	TRENDS IN CARDIOVASCULAR MEDICINE
Volume	19
Issue number	6
DOIs	https://doi.org/10.1016/j.tcm.2009.12.002
Publication status	Published - Aug 2010

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10.1016/j.tcm.2009.12.002

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abstract = "Endothelial dysfunction/death is an initial event for the development of atherosclerosis occurring in the areas of arteries where blood flow is disturbed. Recent data indicated that rapid turnover of endothelial cells in atherosclerosis-prone areas is followed by endothelial repair. The mechanisms of endothelial death/proliferation in these areas related to altered blood flow involve different signal pathways, for example, endoplasmic reticulum stress-X-box binding protein 1-caspase for apoptosis and vascular endothelial growth factor receptor-hi stone deacetylase 3-Akt for the survival. The present review aims to update the progress in endothelial turnover in response to disturbed flow and to discuss the underlining mechanisms in the development of atherosclerosis. (Trends Cardiovasc Med 2009;19:191-195) (C) 2009, Elsevier Inc.",

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AB - Endothelial dysfunction/death is an initial event for the development of atherosclerosis occurring in the areas of arteries where blood flow is disturbed. Recent data indicated that rapid turnover of endothelial cells in atherosclerosis-prone areas is followed by endothelial repair. The mechanisms of endothelial death/proliferation in these areas related to altered blood flow involve different signal pathways, for example, endoplasmic reticulum stress-X-box binding protein 1-caspase for apoptosis and vascular endothelial growth factor receptor-hi stone deacetylase 3-Akt for the survival. The present review aims to update the progress in endothelial turnover in response to disturbed flow and to discuss the underlining mechanisms in the development of atherosclerosis. (Trends Cardiovasc Med 2009;19:191-195) (C) 2009, Elsevier Inc.

U2 - 10.1016/j.tcm.2009.12.002

DO - 10.1016/j.tcm.2009.12.002

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JO - TRENDS IN CARDIOVASCULAR MEDICINE

JF - TRENDS IN CARDIOVASCULAR MEDICINE

IS - 6

ER -

Disturbed flow-enhanced endothelial turnover in atherosclerosis

Abstract

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