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Diverse fate of an enigmatic structure: 200 years of Meckel’s cartilage

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Diverse fate of an enigmatic structure: 200 years of Meckel’s cartilage. / Svandova, Eva; Anthwal, Neal; Tucker, Abigail; Matalova, Eva.

In: Frontiers in Cell and Developmental Biology, Vol. 8, 821, 28.08.2020.

Research output: Contribution to journalReview article

Harvard

Svandova, E, Anthwal, N, Tucker, A & Matalova, E 2020, 'Diverse fate of an enigmatic structure: 200 years of Meckel’s cartilage', Frontiers in Cell and Developmental Biology, vol. 8, 821. https://doi.org/10.3389/fcell.2020.00821

APA

Svandova, E., Anthwal, N., Tucker, A., & Matalova, E. (2020). Diverse fate of an enigmatic structure: 200 years of Meckel’s cartilage. Frontiers in Cell and Developmental Biology, 8, [821]. https://doi.org/10.3389/fcell.2020.00821

Vancouver

Svandova E, Anthwal N, Tucker A, Matalova E. Diverse fate of an enigmatic structure: 200 years of Meckel’s cartilage. Frontiers in Cell and Developmental Biology. 2020 Aug 28;8. 821. https://doi.org/10.3389/fcell.2020.00821

Author

Svandova, Eva ; Anthwal, Neal ; Tucker, Abigail ; Matalova, Eva. / Diverse fate of an enigmatic structure: 200 years of Meckel’s cartilage. In: Frontiers in Cell and Developmental Biology. 2020 ; Vol. 8.

Bibtex Download

@article{a32b9f07da0d491cad1fbba440066266,
title = "Diverse fate of an enigmatic structure: 200 years of Meckel{\textquoteright}s cartilage",
abstract = "Meckel{\textquoteright}s cartilage was first described by the German anatomist Johann Friedrich Meckel the Younger in 1820 from his analysis of human embryos. Two hundred years after its discovery this paper follows the development and largely transient nature of the mammalian Meckel{\textquoteright}s cartilage, and its role in jaw development. Meckel{\textquoteright}s cartilage acts as a jaw support during early development, and a template for the later forming jaw bones. In mammals, its anterior domain links the two arms of the dentary together at the symphysis while the posterior domain ossifies to form two of the three ear ossicles of the middle ear. In between, Meckel{\textquoteright}s cartilage transforms to a ligament or disappears, subsumed by the growing dentary bone. Several human syndromes have been linked, directly or indirectly, to abnormal Meckel{\textquoteright}s cartilage formation. Herein, the evolution, development and fate of the cartilage and its impact on jaw development is mapped. The review focuses on developmental and cellular processes that shed light on the mechanisms behind the different fates of this cartilage, examining the control of Meckel{\textquoteright}s cartilage patterning, initiation and maturation. Importantly, human disorders and mouse models with disrupted Meckel{\textquoteright}s cartilage development are highlighted, in order to understand how changes in this cartilage impact on later development of the dentary and the craniofacial complex as a whole. Finally, the relative roles of tissue interactions, apoptosis, autophagy, macrophages and clast cells in the removal process are discussed. Meckel{\textquoteright}s cartilage is a unique and enigmatic structure, the development and function of which is starting to be understood but many interesting questions still remain.",
keywords = "chondrogenesis, congenital birth defects, craniofacial, jaw development, mammal evolution",
author = "Eva Svandova and Neal Anthwal and Abigail Tucker and Eva Matalova",
year = "2020",
month = aug,
day = "28",
doi = "10.3389/fcell.2020.00821",
language = "English",
volume = "8",
journal = "Frontiers in Cell and Developmental Biology",
issn = "2296-634X",
publisher = "Frontiers Media S.A.",

}

RIS (suitable for import to EndNote) Download

TY - JOUR

T1 - Diverse fate of an enigmatic structure: 200 years of Meckel’s cartilage

AU - Svandova, Eva

AU - Anthwal, Neal

AU - Tucker, Abigail

AU - Matalova, Eva

PY - 2020/8/28

Y1 - 2020/8/28

N2 - Meckel’s cartilage was first described by the German anatomist Johann Friedrich Meckel the Younger in 1820 from his analysis of human embryos. Two hundred years after its discovery this paper follows the development and largely transient nature of the mammalian Meckel’s cartilage, and its role in jaw development. Meckel’s cartilage acts as a jaw support during early development, and a template for the later forming jaw bones. In mammals, its anterior domain links the two arms of the dentary together at the symphysis while the posterior domain ossifies to form two of the three ear ossicles of the middle ear. In between, Meckel’s cartilage transforms to a ligament or disappears, subsumed by the growing dentary bone. Several human syndromes have been linked, directly or indirectly, to abnormal Meckel’s cartilage formation. Herein, the evolution, development and fate of the cartilage and its impact on jaw development is mapped. The review focuses on developmental and cellular processes that shed light on the mechanisms behind the different fates of this cartilage, examining the control of Meckel’s cartilage patterning, initiation and maturation. Importantly, human disorders and mouse models with disrupted Meckel’s cartilage development are highlighted, in order to understand how changes in this cartilage impact on later development of the dentary and the craniofacial complex as a whole. Finally, the relative roles of tissue interactions, apoptosis, autophagy, macrophages and clast cells in the removal process are discussed. Meckel’s cartilage is a unique and enigmatic structure, the development and function of which is starting to be understood but many interesting questions still remain.

AB - Meckel’s cartilage was first described by the German anatomist Johann Friedrich Meckel the Younger in 1820 from his analysis of human embryos. Two hundred years after its discovery this paper follows the development and largely transient nature of the mammalian Meckel’s cartilage, and its role in jaw development. Meckel’s cartilage acts as a jaw support during early development, and a template for the later forming jaw bones. In mammals, its anterior domain links the two arms of the dentary together at the symphysis while the posterior domain ossifies to form two of the three ear ossicles of the middle ear. In between, Meckel’s cartilage transforms to a ligament or disappears, subsumed by the growing dentary bone. Several human syndromes have been linked, directly or indirectly, to abnormal Meckel’s cartilage formation. Herein, the evolution, development and fate of the cartilage and its impact on jaw development is mapped. The review focuses on developmental and cellular processes that shed light on the mechanisms behind the different fates of this cartilage, examining the control of Meckel’s cartilage patterning, initiation and maturation. Importantly, human disorders and mouse models with disrupted Meckel’s cartilage development are highlighted, in order to understand how changes in this cartilage impact on later development of the dentary and the craniofacial complex as a whole. Finally, the relative roles of tissue interactions, apoptosis, autophagy, macrophages and clast cells in the removal process are discussed. Meckel’s cartilage is a unique and enigmatic structure, the development and function of which is starting to be understood but many interesting questions still remain.

KW - chondrogenesis

KW - congenital birth defects

KW - craniofacial

KW - jaw development

KW - mammal evolution

UR - http://www.scopus.com/inward/record.url?scp=85090771980&partnerID=8YFLogxK

U2 - 10.3389/fcell.2020.00821

DO - 10.3389/fcell.2020.00821

M3 - Review article

VL - 8

JO - Frontiers in Cell and Developmental Biology

JF - Frontiers in Cell and Developmental Biology

SN - 2296-634X

M1 - 821

ER -

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