Diverse intracellular pathogens activate type III interferon expression from peroxisomes.

Charlotte Odendall, Evelyn Dixit, Fabrizia Stavru, Helene Bierne, Kate M Franz, Ann Fiegen Durbin, Steeve Boulant, Lee Gehrke, Pascale Cossart, Jonathan C Kagan

Research output: Contribution to journalArticlepeer-review

290 Citations (Scopus)

Abstract

Type I interferon responses are considered the primary means by which viral infections are controlled in mammals. Despite this view, several pathogens activate antiviral responses in the absence of type I interferons. The mechanisms controlling type I interferon-independent responses are undefined. We found that RIG-I like receptors (RLRs) induce type III interferon expression in a variety of human cell types, and identified factors that differentially regulate expression of type I and type III interferons. We identified peroxisomes as a primary site of initiation of type III interferon expression, and revealed that the process of intestinal epithelial cell differentiation upregulates peroxisome biogenesis and promotes robust type III interferon responses in human cells. These findings highlight the importance of different intracellular organelles in specific innate immune responses.
Original languageEnglish
Pages (from-to)717-726
JournalNature Immunology
Volume15
Issue number8
Early online date22 Jun 2014
DOIs
Publication statusPublished - 1 Aug 2014

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