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DNA evidence for strong genetic stability and increasing heritability of intelligence from age 7 to 12

Research output: Contribution to journalArticle

M Trzaskowski, J Yang, P M Visscher, R Plomin

Original languageEnglish
Pages (from-to)380-384
Number of pages5
JournalMolecular Psychiatry
Volume19
Issue number3
Early online date29 Jan 2013
DOIs
Publication statusPublished - Mar 2014

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Abstract

Two genetic findings from twin research have far-reaching implications for understanding individual differences in the development of brain function as indexed by general cognitive ability (g, aka intelligence): (1) The same genes affect g throughout development, even though (2) heritability increases. It is now possible to test these hypotheses using DNA alone. From 1.7 million DNA markers and g scores at ages 7 and 12 on 2875 children, the DNA genetic correlation from age 7 to 12 was 0.73, highly similar to the genetic correlation of 0.75 estimated from 6702 pairs of twins from the same sample. DNA-estimated heritabilities increased from 0.26 at age 7 to 0.45 at age 12; twin-estimated heritabilities also increased from 0.35 to 0.48. These DNA results confirm the results of twin studies indicating strong genetic stability but increasing heritability for g, despite mean changes in brain structure and function from childhood to adolescence.

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