DNA Methylation, Substance Use and Addiction: a Systematic Review of Recent Animal and Human Research from a Developmental Perspective

Charlotte Cecil; Esther Walton; Essi Viding

doi:10.1007/s40429-015-0072-9

DNA Methylation, Substance Use and Addiction: a Systematic Review of Recent Animal and Human Research from a Developmental Perspective

Charlotte Cecil, Esther Walton, Essi Viding

Research output: Contribution to journal › Review article › peer-review

19 Citations (Scopus)

215 Downloads (Pure)

Abstract

Growing evidence points to the role of epigenetic
mechanisms, including DNA methylation, in substance use
and addiction.We conducted a systematic review of 47 recent
(2012–2015) animal and human studies that investigate DNA
methylation and substance use/exposure, spanning preconception
to adulthood. The majority of extant studies (i) focused on
exposure during adulthood, (ii) examined the effects of alcohol
use, (iii) employed a candidate gene approach, and (iv)
were cross-sectional. While studies generally support an association
between substance use/exposure and DNA methylation
and also suggest that developmental context and timing
matter, a dearth of longitudinal data and low comparability
across studies currently limits the conclusions that can be
drawn. Future challenges and directions for the field are
discussed.

Original language	English
Pages (from-to)	331-346
Journal	Current addiction reports
Volume	2
Issue number	4
Early online date	28 Sept 2015
DOIs	https://doi.org/10.1007/s40429-015-0072-9
Publication status	Published - Dec 2015

Keywords

DNA Methylation
Substance Use
Addiction
Development
Epigenetics
Systematic review

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1007/s40429-015-0072-9

Cecil_etal_2015_CurrentAddictionReports_SelfArchivingAccepted author manuscript, 1.04 MB

Cite this

@article{a95de1c9ece34ebca9805012d2a132f7,

title = "DNA Methylation, Substance Use and Addiction: a Systematic Review of Recent Animal and Human Research from a Developmental Perspective",

abstract = "Growing evidence points to the role of epigeneticmechanisms, including DNA methylation, in substance useand addiction.We conducted a systematic review of 47 recent(2012–2015) animal and human studies that investigate DNAmethylation and substance use/exposure, spanning preconceptionto adulthood. The majority of extant studies (i) focused onexposure during adulthood, (ii) examined the effects of alcoholuse, (iii) employed a candidate gene approach, and (iv)were cross-sectional. While studies generally support an associationbetween substance use/exposure and DNA methylationand also suggest that developmental context and timingmatter, a dearth of longitudinal data and low comparabilityacross studies currently limits the conclusions that can bedrawn. Future challenges and directions for the field arediscussed.",

keywords = "DNA Methylation, Substance Use, Addiction, Development, Epigenetics, Systematic review",

author = "Charlotte Cecil and Esther Walton and Essi Viding",

year = "2015",

month = dec,

doi = "10.1007/s40429-015-0072-9",

language = "English",

volume = "2",

pages = "331--346",

journal = "Current addiction reports",

issn = "2196-2952",

publisher = "Springer Nature Switzerland AG",

number = "4",

}

TY - JOUR

T1 - DNA Methylation, Substance Use and Addiction: a Systematic Review of Recent Animal and Human Research from a Developmental Perspective

AU - Cecil, Charlotte

AU - Walton, Esther

AU - Viding, Essi

PY - 2015/12

Y1 - 2015/12

N2 - Growing evidence points to the role of epigeneticmechanisms, including DNA methylation, in substance useand addiction.We conducted a systematic review of 47 recent(2012–2015) animal and human studies that investigate DNAmethylation and substance use/exposure, spanning preconceptionto adulthood. The majority of extant studies (i) focused onexposure during adulthood, (ii) examined the effects of alcoholuse, (iii) employed a candidate gene approach, and (iv)were cross-sectional. While studies generally support an associationbetween substance use/exposure and DNA methylationand also suggest that developmental context and timingmatter, a dearth of longitudinal data and low comparabilityacross studies currently limits the conclusions that can bedrawn. Future challenges and directions for the field arediscussed.

AB - Growing evidence points to the role of epigeneticmechanisms, including DNA methylation, in substance useand addiction.We conducted a systematic review of 47 recent(2012–2015) animal and human studies that investigate DNAmethylation and substance use/exposure, spanning preconceptionto adulthood. The majority of extant studies (i) focused onexposure during adulthood, (ii) examined the effects of alcoholuse, (iii) employed a candidate gene approach, and (iv)were cross-sectional. While studies generally support an associationbetween substance use/exposure and DNA methylationand also suggest that developmental context and timingmatter, a dearth of longitudinal data and low comparabilityacross studies currently limits the conclusions that can bedrawn. Future challenges and directions for the field arediscussed.

KW - DNA Methylation

KW - Substance Use

KW - Addiction

KW - Development

KW - Epigenetics

KW - Systematic review

U2 - 10.1007/s40429-015-0072-9

DO - 10.1007/s40429-015-0072-9

M3 - Review article

SN - 2196-2952

VL - 2

SP - 331

EP - 346

JO - Current addiction reports

JF - Current addiction reports

IS - 4

ER -

DNA Methylation, Substance Use and Addiction: a Systematic Review of Recent Animal and Human Research from a Developmental Perspective

Abstract

Keywords

UN SDGs

Access to Document

Fingerprint

Cite this