Do Defective Immune System-Mediated Myelination Processes Increase Postpartum Psychosis Risk?

TY - JOUR

T1 - Do Defective Immune System-Mediated Myelination Processes Increase Postpartum Psychosis Risk?

AU - Dazzan, Paola

AU - Fusté, Montserrat

AU - Davies, William

N1 - Copyright © 2018 The Authors. Published by Elsevier Ltd.. All rights reserved.

PY - 2018/10/19

Y1 - 2018/10/19

N2 - Postpartum (or puerperal) psychosis (PP) is a rare, severe psychiatric disorder that affects women shortly after childbirth; risk is particularly high in individuals with a history of bipolar disorder or PP, but the underlying pathophysiology remains poorly understood. Emerging evidence suggests that immune system (dys)function plays an important role in disorder onset. On the basis of new findings from clinical and animal model studies, we hypothesise that the abundance and/or activity of regulatory T cells, and the efficacy of consequent (re)myelination processes in the brain mediated by CCN proteins, is perturbed in PP; this pathway may be modulated by risk and protective/treatment factors for the disorder, and identifying abnormalities within it could signpost novel predictive biomarkers and therapeutic targets.

AB - Postpartum (or puerperal) psychosis (PP) is a rare, severe psychiatric disorder that affects women shortly after childbirth; risk is particularly high in individuals with a history of bipolar disorder or PP, but the underlying pathophysiology remains poorly understood. Emerging evidence suggests that immune system (dys)function plays an important role in disorder onset. On the basis of new findings from clinical and animal model studies, we hypothesise that the abundance and/or activity of regulatory T cells, and the efficacy of consequent (re)myelination processes in the brain mediated by CCN proteins, is perturbed in PP; this pathway may be modulated by risk and protective/treatment factors for the disorder, and identifying abnormalities within it could signpost novel predictive biomarkers and therapeutic targets.

U2 - 10.1016/j.molmed.2018.09.002

DO - 10.1016/j.molmed.2018.09.002

M3 - Review article

C2 - 30348609

SN - 1471-4914

JO - TRENDS IN MOLECULAR MEDICINE

JF - TRENDS IN MOLECULAR MEDICINE

ER -