TY - JOUR
T1 - Do ethnobotanical and laboratory data predict clinical safety and efficacy of anti-malarial plants?
AU - Willcox, Merlin
AU - Benoit-Vical, Francoise
AU - Fowler, Dennis
AU - Bourdy, Genevieve
AU - Burford, Gemma
AU - Giani, Sergio
AU - Graziose, Rocky
AU - Houghton, Peter
AU - Randrianarivelojosia, Milijaona
AU - Rasoanaivo, Philippe
PY - 2011
Y1 - 2011
N2 - Background: Over 1200 plant species are reported in ethnobotanical studies for the treatment of malaria and fevers, so it is important to prioritize plants for further development of anti-malarials.
Methods: The "RITAM score" was designed to combine information from systematic literature searches of published ethnobotanical studies and laboratory pharmacological studies of efficacy and safety, in order to prioritize plants for further research. It was evaluated by correlating it with the results of clinical trials.
Results and discussion: The laboratory efficacy score correlated with clinical parasite clearance (r(s)=0.7). The ethnobotanical component correlated weakly with clinical symptom clearance but not with parasite clearance. The safety component was difficult to validate as all plants entering clinical trials were generally considered safe, so there was no clinical data on toxic plants.
Conclusion: The RITAM score (especially the efficacy and safety components) can be used as part of the selection process for prioritising plants for further research as anti-malarial drug candidates. The validation in this study was limited by the very small number of available clinical studies, and the heterogeneity of patients included.
AB - Background: Over 1200 plant species are reported in ethnobotanical studies for the treatment of malaria and fevers, so it is important to prioritize plants for further development of anti-malarials.
Methods: The "RITAM score" was designed to combine information from systematic literature searches of published ethnobotanical studies and laboratory pharmacological studies of efficacy and safety, in order to prioritize plants for further research. It was evaluated by correlating it with the results of clinical trials.
Results and discussion: The laboratory efficacy score correlated with clinical parasite clearance (r(s)=0.7). The ethnobotanical component correlated weakly with clinical symptom clearance but not with parasite clearance. The safety component was difficult to validate as all plants entering clinical trials were generally considered safe, so there was no clinical data on toxic plants.
Conclusion: The RITAM score (especially the efficacy and safety components) can be used as part of the selection process for prioritising plants for further research as anti-malarial drug candidates. The validation in this study was limited by the very small number of available clinical studies, and the heterogeneity of patients included.
M3 - Literature review
VL - 10
JO - Malaria Journal
JF - Malaria Journal
IS - SUPPL. 1
M1 - S7
ER -
