Do statins have a role in preventing or treating sepsis?

TY - JOUR

T1 - Do statins have a role in preventing or treating sepsis?

AU - Novack, Victor

AU - Terblanche, Marius

AU - Almog, Yaniv

PY - 2006/1/23

Y1 - 2006/1/23

N2 - Statins have a variety of properties that are independent of their lipid lowering ability. These anti-inflammatory, antioxidant, immunomodulatory, and antiapoptotic features have been collectively referred to as pleiotropic effects. Severe sepsis is an intense infection-induced inflammatory syndrome that ultimately results in organ dysfunction. Because so many cascades are triggered during sepsis, merely blocking a single component may be insufficient to arrest the inflammatory process. A growing body of evidence suggests that statins may indeed have a protective effect against severe sepsis and reduce the rate of infection-related mortality. This novel primary prevention concept may have far-reaching implications for the future management of serious infections. Moreover, it was recently shown that statins potentially improve outcome after the onset of sepsis. The stage is now set for randomized clinical trials that will determine the precise role, if any, that statins may have in preventing and treating sepsis.

AB - Statins have a variety of properties that are independent of their lipid lowering ability. These anti-inflammatory, antioxidant, immunomodulatory, and antiapoptotic features have been collectively referred to as pleiotropic effects. Severe sepsis is an intense infection-induced inflammatory syndrome that ultimately results in organ dysfunction. Because so many cascades are triggered during sepsis, merely blocking a single component may be insufficient to arrest the inflammatory process. A growing body of evidence suggests that statins may indeed have a protective effect against severe sepsis and reduce the rate of infection-related mortality. This novel primary prevention concept may have far-reaching implications for the future management of serious infections. Moreover, it was recently shown that statins potentially improve outcome after the onset of sepsis. The stage is now set for randomized clinical trials that will determine the precise role, if any, that statins may have in preventing and treating sepsis.

KW - ENDOTHELIAL-CELLS

KW - IMPROVES SURVIVAL

KW - HEME OXYGENASE-1

KW - MURINE MODEL

KW - THERAPY

KW - INFLAMMATION

KW - PROTEIN

U2 - 10.1186/cc3972

DO - 10.1186/cc3972

M3 - Editorial

SN - 1466-609X

VL - 10

JO - CRITICAL CARE

JF - CRITICAL CARE

IS - 1

M1 - 113

ER -