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Does cannabis complement or substitute alcohol consumption? A systematic review of human and animal studies

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Does cannabis complement or substitute alcohol consumption? A systematic review of human and animal studies. / Risso, Constanza; Boniface, Sadie; Subbaraman, Meenakshi Sabina; Englund, Amir.

In: Journal of Psychopharmacology, Vol. 34, No. 9, 01.09.2020, p. 938-954.

Research output: Contribution to journalArticle

Harvard

Risso, C, Boniface, S, Subbaraman, MS & Englund, A 2020, 'Does cannabis complement or substitute alcohol consumption? A systematic review of human and animal studies', Journal of Psychopharmacology, vol. 34, no. 9, pp. 938-954. https://doi.org/10.1177/0269881120919970

APA

Risso, C., Boniface, S., Subbaraman, M. S., & Englund, A. (2020). Does cannabis complement or substitute alcohol consumption? A systematic review of human and animal studies. Journal of Psychopharmacology, 34(9), 938-954. https://doi.org/10.1177/0269881120919970

Vancouver

Risso C, Boniface S, Subbaraman MS, Englund A. Does cannabis complement or substitute alcohol consumption? A systematic review of human and animal studies. Journal of Psychopharmacology. 2020 Sep 1;34(9):938-954. https://doi.org/10.1177/0269881120919970

Author

Risso, Constanza ; Boniface, Sadie ; Subbaraman, Meenakshi Sabina ; Englund, Amir. / Does cannabis complement or substitute alcohol consumption? A systematic review of human and animal studies. In: Journal of Psychopharmacology. 2020 ; Vol. 34, No. 9. pp. 938-954.

Bibtex Download

@article{374befb11ce84b939e3eab5dc8b57b52,
title = "Does cannabis complement or substitute alcohol consumption? A systematic review of human and animal studies",
abstract = "Background: Whether alcohol and cannabis complement or substitute each other has been studied for over two decades. In the changing cannabis policy landscape, debates are moving rapidly and spill-over effects on other substances are of interest. Aims: update and extend a previous systematic review, by: (a) identifying new human behavioural studies reporting on substitution and/or complementarity of alcohol and cannabis, and (b) additionally including animal studies. Methods: We replicated the search strategy of an earlier systematic review, supplemented with a new search for animal studies. Search results were crossed checked against the earlier review and reference lists were hand searched. Findings were synthesised using a narrative synthesis. Results: Sixty-five articles were included (64 in humans, one in animals). We synthesised findings into categories: patterns of use, substitution practices, economic relationship, substance use disorders, policy evaluation, others and animal studies. Overall, 30 studies found evidence for substitution, 17 for complementarity, 14 did not find evidence for either, and four found evidence for both. Conclusions: Overall, the evidence regarding complementarity and substitution of cannabis and alcohol is mixed. We identified stronger support for substitution than complementarity, though evidence indicates different effects in different populations and to some extent across different study designs. The quality of studies varied and few were designed specifically to address this question. Dedicated high-quality research is warranted.",
keywords = "alcohol, and complementarity, Cannabis, substitution",
author = "Constanza Risso and Sadie Boniface and Subbaraman, {Meenakshi Sabina} and Amir Englund",
year = "2020",
month = sep,
day = "1",
doi = "10.1177/0269881120919970",
language = "English",
volume = "34",
pages = "938--954",
journal = "Journal of Psychopharmacology",
issn = "0269-8811",
publisher = "SAGE Publications Ltd STM",
number = "9",

}

RIS (suitable for import to EndNote) Download

TY - JOUR

T1 - Does cannabis complement or substitute alcohol consumption? A systematic review of human and animal studies

AU - Risso, Constanza

AU - Boniface, Sadie

AU - Subbaraman, Meenakshi Sabina

AU - Englund, Amir

PY - 2020/9/1

Y1 - 2020/9/1

N2 - Background: Whether alcohol and cannabis complement or substitute each other has been studied for over two decades. In the changing cannabis policy landscape, debates are moving rapidly and spill-over effects on other substances are of interest. Aims: update and extend a previous systematic review, by: (a) identifying new human behavioural studies reporting on substitution and/or complementarity of alcohol and cannabis, and (b) additionally including animal studies. Methods: We replicated the search strategy of an earlier systematic review, supplemented with a new search for animal studies. Search results were crossed checked against the earlier review and reference lists were hand searched. Findings were synthesised using a narrative synthesis. Results: Sixty-five articles were included (64 in humans, one in animals). We synthesised findings into categories: patterns of use, substitution practices, economic relationship, substance use disorders, policy evaluation, others and animal studies. Overall, 30 studies found evidence for substitution, 17 for complementarity, 14 did not find evidence for either, and four found evidence for both. Conclusions: Overall, the evidence regarding complementarity and substitution of cannabis and alcohol is mixed. We identified stronger support for substitution than complementarity, though evidence indicates different effects in different populations and to some extent across different study designs. The quality of studies varied and few were designed specifically to address this question. Dedicated high-quality research is warranted.

AB - Background: Whether alcohol and cannabis complement or substitute each other has been studied for over two decades. In the changing cannabis policy landscape, debates are moving rapidly and spill-over effects on other substances are of interest. Aims: update and extend a previous systematic review, by: (a) identifying new human behavioural studies reporting on substitution and/or complementarity of alcohol and cannabis, and (b) additionally including animal studies. Methods: We replicated the search strategy of an earlier systematic review, supplemented with a new search for animal studies. Search results were crossed checked against the earlier review and reference lists were hand searched. Findings were synthesised using a narrative synthesis. Results: Sixty-five articles were included (64 in humans, one in animals). We synthesised findings into categories: patterns of use, substitution practices, economic relationship, substance use disorders, policy evaluation, others and animal studies. Overall, 30 studies found evidence for substitution, 17 for complementarity, 14 did not find evidence for either, and four found evidence for both. Conclusions: Overall, the evidence regarding complementarity and substitution of cannabis and alcohol is mixed. We identified stronger support for substitution than complementarity, though evidence indicates different effects in different populations and to some extent across different study designs. The quality of studies varied and few were designed specifically to address this question. Dedicated high-quality research is warranted.

KW - alcohol

KW - and complementarity

KW - Cannabis

KW - substitution

UR - http://www.scopus.com/inward/record.url?scp=85087743595&partnerID=8YFLogxK

U2 - 10.1177/0269881120919970

DO - 10.1177/0269881120919970

M3 - Article

AN - SCOPUS:85087743595

VL - 34

SP - 938

EP - 954

JO - Journal of Psychopharmacology

JF - Journal of Psychopharmacology

SN - 0269-8811

IS - 9

ER -

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