TY - JOUR
T1 - Does physical activity reduce the risk of psychosis?
T2 - A systematic review and meta-analysis of prospective studies
AU - Brokmeier, Luisa Leonie
AU - Firth, Joseph
AU - Vancampfort, Davy
AU - Smith, Lee
AU - Deenik, Jeroen
AU - Rosenbaum, Simon
AU - Stubbs, Brendon
AU - Schuch, Felipe Barreto
N1 - Crown Copyright © 2019. Published by Elsevier B.V. All rights reserved.
PY - 2019/11/14
Y1 - 2019/11/14
N2 - Longitudinal prospective cohorts have suggested that physical activity (PA) may be a protective factor against psychosis and schizophrenia. However, no meta-analysis has been conducted. The study aims to examine the prospective relationship between PA and incident psychosis/schizophrenia. Major databases were searched from inception to July 2019 for prospective studies that calculated the odds ratio (OR) or the adjusted odds ratio (AOR) of incident psychosis/schizophrenia in people with higher PA against people with lower PA. Methodological quality was assessed using the Newcastle-Ottawa Scale (NOS). A random-effects meta-analysis was conducted, for OR and AOR, separately. Across 4 cohorts (N = 30,025 median males = 50%, median follow-up = 32 years), people with high self-reported PA (versus low PA) were at reduced odds of developing psychosis/schizophrenia (OR = 0.73, 95%CI 0.532 to 0.995, p = 0.047). Analysis including 2 cohorts presenting AOR were not statistically significant (AOR = 0.59, 95%CI 0.253 to 1.383, p = 0.226). Overall study quality was high (mean NOS = 7.0). The literature on the topic is scarce, whilst crude analysis suggests that PA may be a protective factor against the emergence of psychosis/schizophrenia, but when adjusting for covariates, the association is no longer significant. Further studies with objective physical activity and adjustment for confounders are needed.
AB - Longitudinal prospective cohorts have suggested that physical activity (PA) may be a protective factor against psychosis and schizophrenia. However, no meta-analysis has been conducted. The study aims to examine the prospective relationship between PA and incident psychosis/schizophrenia. Major databases were searched from inception to July 2019 for prospective studies that calculated the odds ratio (OR) or the adjusted odds ratio (AOR) of incident psychosis/schizophrenia in people with higher PA against people with lower PA. Methodological quality was assessed using the Newcastle-Ottawa Scale (NOS). A random-effects meta-analysis was conducted, for OR and AOR, separately. Across 4 cohorts (N = 30,025 median males = 50%, median follow-up = 32 years), people with high self-reported PA (versus low PA) were at reduced odds of developing psychosis/schizophrenia (OR = 0.73, 95%CI 0.532 to 0.995, p = 0.047). Analysis including 2 cohorts presenting AOR were not statistically significant (AOR = 0.59, 95%CI 0.253 to 1.383, p = 0.226). Overall study quality was high (mean NOS = 7.0). The literature on the topic is scarce, whilst crude analysis suggests that PA may be a protective factor against the emergence of psychosis/schizophrenia, but when adjusting for covariates, the association is no longer significant. Further studies with objective physical activity and adjustment for confounders are needed.
KW - Longitudinal
KW - Physical activity
KW - Protective
KW - Psychosis
KW - Risk factor
KW - Schizophrenia
KW - incidence
UR - http://www.scopus.com/inward/record.url?scp=85076048481&partnerID=8YFLogxK
U2 - 10.1016/j.psychres.2019.112675
DO - 10.1016/j.psychres.2019.112675
M3 - Review article
C2 - 31757637
SN - 0165-1781
SP - 112675
JO - Psychiatry Research
JF - Psychiatry Research
M1 - 112675
ER -