Does the association between birth weight and blood pressure increase with age? A longitudinal study in young adults

Patricia Bustos, Hugo Amigo, Shrikant Bangdiwala, Tito Pizarro, Roberto Jorge Rona

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4 Citations (Scopus)
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Abstract

Objectives: To assess whether the association between
birth weight and blood pressure (BP) increases with age
using three different statistical methods.
Methods: A representative sample of 1232 study
participants born between 1974–1978 in Limache, Chile
were assessed in 2000–2002, of whom 796 were
reassessed in 2010–2012. An ‘amplification effect’ was
assessed by the change in the b coefficient in the two
periods, the association between birth weight and the
difference of BP overtime, and the interaction between
birth weight and BP in the two periods.
Results: Birth weight was negatively associated with SBP in
2000–2002 (b¼2.46, 95% confidence interval (CI) 3.77
to 1.16) and in 2010–2012 (b¼3.64, 95% CI 5.20 to
2.08), and with DBP in 2000–2002 (b¼1.26, 95% CI
2.23 to 0.29) , and 2010–2012 (b¼1.64, 95% CI
2.84 to 0.45) after adjustment for sex, physical activity,
and BMI. There was no association between birth weight
and the difference in BP between the two periods or the
interaction between birth weight, BP, and time interval.
Conclusion: Birth weight is a factor associated with BP in
adults. This association increased with age, but
amplification was shown only with one of the three
methods.
Original languageEnglish
Pages (from-to)1-6
Number of pages6
JournalJournal of Hypertension
Volume34
Issue number6
Early online dateApr 2016
DOIs
Publication statusPublished - Jun 2016

Keywords

  • adult, age-related trend, birth weight, blood pressure

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