TY - JOUR
T1 - Does the Lectin Complement Pathway Link Kawasaki Disease and SARS-CoV-2?
AU - Polycarpou, Anastasia
AU - Grigoriadou, Sofia
AU - Klavinskis, Linda
AU - Sacks, Steven
N1 - Funding Information:
Previously published research by our laboratories was supported by the UK Medical Research Council (grants MR/J006742/1, MR/L020254/1, G1001141, MR/J004553/1, MR/M007871/1 and MR/L012758/1), the National Institute for Health Research (NIHR) Biomedical Research Centre based at Guy’s and St Thomas’s NHS (grant RE12572), The Bill and Melinda Gates Foundation, Seattle, WA grant number 38639 and European Union Marie Curie Initial Training Network (UniVacFlu) grant number 607690 to LK.
Copyright:
Copyright 2021 Elsevier B.V., All rights reserved.
PY - 2021/1/14
Y1 - 2021/1/14
N2 - Out of the mire of the COVID-19 pandemic, caused by the novel coronavirus SARS-CoV-2, a new clue on pathogenesis has emerged regarding multisystem inflammatory disease in children with evidence of endotheliitis and microvascular thrombosis, with striking similarities to Kawasaki disease. Here we consider whether the complement system could underpin these connections, in particular the lectin pathway - the most recent and perhaps least understood of the three main activation pathways known to unleash the complement cascade. We have evaluated the published evidence linking the complement system with both Kawasaki disease and COVID-19 associated acute respiratory distress syndrome (ARDS) and we conclude that the complement system could be a therapeutic target for the Kawasaki-like syndrome triggered by SARS-CoV-2.
AB - Out of the mire of the COVID-19 pandemic, caused by the novel coronavirus SARS-CoV-2, a new clue on pathogenesis has emerged regarding multisystem inflammatory disease in children with evidence of endotheliitis and microvascular thrombosis, with striking similarities to Kawasaki disease. Here we consider whether the complement system could underpin these connections, in particular the lectin pathway - the most recent and perhaps least understood of the three main activation pathways known to unleash the complement cascade. We have evaluated the published evidence linking the complement system with both Kawasaki disease and COVID-19 associated acute respiratory distress syndrome (ARDS) and we conclude that the complement system could be a therapeutic target for the Kawasaki-like syndrome triggered by SARS-CoV-2.
KW - Lectin, complement, COVID-19
UR - http://www.scopus.com/inward/record.url?scp=85100519506&partnerID=8YFLogxK
U2 - 10.3389/fimmu.2020.604512
DO - 10.3389/fimmu.2020.604512
M3 - Article
SN - 1664-3224
VL - 11
JO - Frontiers in Immunology
JF - Frontiers in Immunology
M1 - 604512
ER -