Does the sympathetic nervous system influence sinus arrhythmia in man?: Evidence from combined autonomic blockade

R. Coker; A. Koziell; C. Oliver; S. E. Smith

doi:10.1113/jphysiol.1984.sp015476

Does the sympathetic nervous system influence sinus arrhythmia in man? Evidence from combined autonomic blockade

R. Coker, A. Koziell, C. Oliver, S. E. Smith

Research output: Contribution to journal › Article › peer-review

62 Citations (Scopus)

Abstract

The influences of vagal and sympathetic efferent activity on sinus arrhythmia in man have been studied in healthy subjects by administration of hyoscine butylbromide and atenolol alone and combined using a microcomputer-linked electrocardiogram (e.c.g.) system. Sinus arrhythmia was quantitated as the S.D. of the R-R interval. Sinus arrhythmia was reduced by hyoscine butylbromide, in some subjects to near abolition, but this end-point was unchanged by pre-treatment with atenolol. Atenolol alone prolonged the mean R-R interval and increased sinus arrhythmia. It is suggested that sinus arrhythmia in man is mediated through vagal efferents alone but that atenolol increases the arrhythmia through a central vagotonic effect.

Original language	English
Pages (from-to)	459-64
Number of pages	6
Journal	The Journal of physiology
Volume	356
Issue number	1
DOIs	https://doi.org/10.1113/jphysiol.1984.sp015476
Publication status	Published - Nov 1984

Keywords

Adult
Arrhythmia, Sinus
Atenolol
Autonomic Nerve Block
Butylscopolammonium Bromide
Efferent Pathways
Electrocardiography
Female
Humans
Male
Sympathetic Nervous System

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10.1113/jphysiol.1984.sp015476

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title = "Does the sympathetic nervous system influence sinus arrhythmia in man?: Evidence from combined autonomic blockade",

abstract = "The influences of vagal and sympathetic efferent activity on sinus arrhythmia in man have been studied in healthy subjects by administration of hyoscine butylbromide and atenolol alone and combined using a microcomputer-linked electrocardiogram (e.c.g.) system. Sinus arrhythmia was quantitated as the S.D. of the R-R interval. Sinus arrhythmia was reduced by hyoscine butylbromide, in some subjects to near abolition, but this end-point was unchanged by pre-treatment with atenolol. Atenolol alone prolonged the mean R-R interval and increased sinus arrhythmia. It is suggested that sinus arrhythmia in man is mediated through vagal efferents alone but that atenolol increases the arrhythmia through a central vagotonic effect.",

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doi = "10.1113/jphysiol.1984.sp015476",

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T1 - Does the sympathetic nervous system influence sinus arrhythmia in man?

T2 - Evidence from combined autonomic blockade

AU - Coker, R.

AU - Koziell, A.

AU - Oliver, C.

AU - Smith, S. E.

PY - 1984/11

Y1 - 1984/11

N2 - The influences of vagal and sympathetic efferent activity on sinus arrhythmia in man have been studied in healthy subjects by administration of hyoscine butylbromide and atenolol alone and combined using a microcomputer-linked electrocardiogram (e.c.g.) system. Sinus arrhythmia was quantitated as the S.D. of the R-R interval. Sinus arrhythmia was reduced by hyoscine butylbromide, in some subjects to near abolition, but this end-point was unchanged by pre-treatment with atenolol. Atenolol alone prolonged the mean R-R interval and increased sinus arrhythmia. It is suggested that sinus arrhythmia in man is mediated through vagal efferents alone but that atenolol increases the arrhythmia through a central vagotonic effect.

AB - The influences of vagal and sympathetic efferent activity on sinus arrhythmia in man have been studied in healthy subjects by administration of hyoscine butylbromide and atenolol alone and combined using a microcomputer-linked electrocardiogram (e.c.g.) system. Sinus arrhythmia was quantitated as the S.D. of the R-R interval. Sinus arrhythmia was reduced by hyoscine butylbromide, in some subjects to near abolition, but this end-point was unchanged by pre-treatment with atenolol. Atenolol alone prolonged the mean R-R interval and increased sinus arrhythmia. It is suggested that sinus arrhythmia in man is mediated through vagal efferents alone but that atenolol increases the arrhythmia through a central vagotonic effect.

KW - Adult

KW - Arrhythmia, Sinus

KW - Atenolol

KW - Autonomic Nerve Block

KW - Butylscopolammonium Bromide

KW - Efferent Pathways

KW - Electrocardiography

KW - Female

KW - Humans

KW - Male

KW - Sympathetic Nervous System

U2 - 10.1113/jphysiol.1984.sp015476

DO - 10.1113/jphysiol.1984.sp015476

M3 - Article

C2 - 6520795

SN - 0022-3751

VL - 356

SP - 459

EP - 464

JO - The Journal of physiology

JF - The Journal of physiology

IS - 1

ER -

Does the sympathetic nervous system influence sinus arrhythmia in man? Evidence from combined autonomic blockade

Abstract

Keywords

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