Dopamine D4 receptor gene and severity of dependence

J Lusher; L Ebersole; D Ball

doi:10.1111/j.1369-1600.2000.tb00217.x

Dopamine D4 receptor gene and severity of dependence

J Lusher, L Ebersole, D Ball

Research output: Contribution to journal › Article › peer-review

18 Citations (Scopus)

Abstract

Family, twin and adoption studies demonstrate that substance dependence is deter mined partially by genes. Recent studies in opiate-dependent subjects have found a significant excess of the long-long (LL) allele of the 48bp repeat in the coding sequence of the DRD4 gene. This study examined this association fur ther in a sample of 60 opiate dependent, 51 alcohol-dependent and 64 nor mal, healthy control subjects. No significant association between the polymorphism at DRD4 and opiate or alcohol abuse was found. However, results yielded a significant main effect on severity of dependence, demonstrating that individuals with the LL allele rated their severity of dependence significantly higher than those who had the short-short (SS) allele :[F(2, 101) = 5.0, p <0.01]. This study suggests that the DRD4 gene does not directly influence vulnerability to substance dependence, but that possession of the LL genotype significantly increases severity of dependence.

Original language	English
Pages (from-to)	469 - 472
Number of pages	4
Journal	Addiction Biology
Volume	5
Issue number	4
DOIs	https://doi.org/10.1111/j.1369-1600.2000.tb00217.x
Publication status	Published - 2000

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title = "Dopamine D4 receptor gene and severity of dependence",

abstract = "Family, twin and adoption studies demonstrate that substance dependence is deter mined partially by genes. Recent studies in opiate-dependent subjects have found a significant excess of the long-long (LL) allele of the 48bp repeat in the coding sequence of the DRD4 gene. This study examined this association fur ther in a sample of 60 opiate dependent, 51 alcohol-dependent and 64 nor mal, healthy control subjects. No significant association between the polymorphism at DRD4 and opiate or alcohol abuse was found. However, results yielded a significant main effect on severity of dependence, demonstrating that individuals with the LL allele rated their severity of dependence significantly higher than those who had the short-short (SS) allele :[F(2, 101) = 5.0, p <0.01]. This study suggests that the DRD4 gene does not directly influence vulnerability to substance dependence, but that possession of the LL genotype significantly increases severity of dependence.",

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T1 - Dopamine D4 receptor gene and severity of dependence

AU - Lusher, J

AU - Ebersole, L

AU - Ball, D

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AB - Family, twin and adoption studies demonstrate that substance dependence is deter mined partially by genes. Recent studies in opiate-dependent subjects have found a significant excess of the long-long (LL) allele of the 48bp repeat in the coding sequence of the DRD4 gene. This study examined this association fur ther in a sample of 60 opiate dependent, 51 alcohol-dependent and 64 nor mal, healthy control subjects. No significant association between the polymorphism at DRD4 and opiate or alcohol abuse was found. However, results yielded a significant main effect on severity of dependence, demonstrating that individuals with the LL allele rated their severity of dependence significantly higher than those who had the short-short (SS) allele :[F(2, 101) = 5.0, p <0.01]. This study suggests that the DRD4 gene does not directly influence vulnerability to substance dependence, but that possession of the LL genotype significantly increases severity of dependence.

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JO - Addiction Biology

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Dopamine D4 receptor gene and severity of dependence

Abstract

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