King's College London

Research portal

Dopamine manipulations modulate paranoid social inferences in healthy people.

Research output: Contribution to journalArticlepeer-review

Standard

Dopamine manipulations modulate paranoid social inferences in healthy people. / Barnby, Joe; Deeley, Quinton; Bell, Vaughan et al.

In: Translational psychiatry, 11.06.2020.

Research output: Contribution to journalArticlepeer-review

Harvard

Barnby, J, Deeley, Q, Bell, V & Mehta, M 2020, 'Dopamine manipulations modulate paranoid social inferences in healthy people.', Translational psychiatry.

APA

Barnby, J., Deeley, Q., Bell, V., & Mehta, M. (Accepted/In press). Dopamine manipulations modulate paranoid social inferences in healthy people. Translational psychiatry.

Vancouver

Barnby J, Deeley Q, Bell V, Mehta M. Dopamine manipulations modulate paranoid social inferences in healthy people. Translational psychiatry. 2020 Jun 11.

Author

Barnby, Joe ; Deeley, Quinton ; Bell, Vaughan et al. / Dopamine manipulations modulate paranoid social inferences in healthy people. In: Translational psychiatry. 2020.

Bibtex Download

@article{0571df4dc3be421a9cdbe75ad6b71c78,
title = "Dopamine manipulations modulate paranoid social inferences in healthy people.",
abstract = "Altered dopamine transmission is thought to influence the formation of persecutory delusions. However, despite extensive evidence from clinical studies there is little experimental evidence on how modulating the dopamine system changes social attributions related to paranoia, and the salience of beliefs more generally. 27 healthy male participants received 150mg L-DOPA, 3mg haloperidol, or placebo in a double blind, randomised, placebo-controlled study, over three within-subject sessions. Participants completed a multi-round Dictator Game modified to measure social attributions, and a measure of belief salience spanning themes of politics, religion, science, morality, and the paranormal. We preregistered predictions that altering dopamine function would affect i) attributions of harmful intent and ii) salience of paranormal beliefs. As predicted, haloperidol reduced attributions of harmful intent across all conditions compared to placebo. L-DOPA reduced attributions of harmful intent in fair conditions compared to placebo. Unexpectedly, haloperidol increased attributions of self-interest about opponents{\textquoteright} decisions. There was no change in belief salience within any theme. These results could not be explained by scepticism or subjective mood. Our findings demonstrate the selective involvement of dopamine in social inferences related to paranoia in healthy individuals.",
author = "Joe Barnby and Quinton Deeley and Vaughan Bell and Mitul Mehta",
year = "2020",
month = jun,
day = "11",
language = "English",
journal = "Translational psychiatry",
issn = "2158-3188",
publisher = "Nature Publishing Group",

}

RIS (suitable for import to EndNote) Download

TY - JOUR

T1 - Dopamine manipulations modulate paranoid social inferences in healthy people.

AU - Barnby, Joe

AU - Deeley, Quinton

AU - Bell, Vaughan

AU - Mehta, Mitul

PY - 2020/6/11

Y1 - 2020/6/11

N2 - Altered dopamine transmission is thought to influence the formation of persecutory delusions. However, despite extensive evidence from clinical studies there is little experimental evidence on how modulating the dopamine system changes social attributions related to paranoia, and the salience of beliefs more generally. 27 healthy male participants received 150mg L-DOPA, 3mg haloperidol, or placebo in a double blind, randomised, placebo-controlled study, over three within-subject sessions. Participants completed a multi-round Dictator Game modified to measure social attributions, and a measure of belief salience spanning themes of politics, religion, science, morality, and the paranormal. We preregistered predictions that altering dopamine function would affect i) attributions of harmful intent and ii) salience of paranormal beliefs. As predicted, haloperidol reduced attributions of harmful intent across all conditions compared to placebo. L-DOPA reduced attributions of harmful intent in fair conditions compared to placebo. Unexpectedly, haloperidol increased attributions of self-interest about opponents’ decisions. There was no change in belief salience within any theme. These results could not be explained by scepticism or subjective mood. Our findings demonstrate the selective involvement of dopamine in social inferences related to paranoia in healthy individuals.

AB - Altered dopamine transmission is thought to influence the formation of persecutory delusions. However, despite extensive evidence from clinical studies there is little experimental evidence on how modulating the dopamine system changes social attributions related to paranoia, and the salience of beliefs more generally. 27 healthy male participants received 150mg L-DOPA, 3mg haloperidol, or placebo in a double blind, randomised, placebo-controlled study, over three within-subject sessions. Participants completed a multi-round Dictator Game modified to measure social attributions, and a measure of belief salience spanning themes of politics, religion, science, morality, and the paranormal. We preregistered predictions that altering dopamine function would affect i) attributions of harmful intent and ii) salience of paranormal beliefs. As predicted, haloperidol reduced attributions of harmful intent across all conditions compared to placebo. L-DOPA reduced attributions of harmful intent in fair conditions compared to placebo. Unexpectedly, haloperidol increased attributions of self-interest about opponents’ decisions. There was no change in belief salience within any theme. These results could not be explained by scepticism or subjective mood. Our findings demonstrate the selective involvement of dopamine in social inferences related to paranoia in healthy individuals.

M3 - Article

JO - Translational psychiatry

JF - Translational psychiatry

SN - 2158-3188

ER -

View graph of relations

© 2020 King's College London | Strand | London WC2R 2LS | England | United Kingdom | Tel +44 (0)20 7836 5454