Dopamine markers and general cognitive ability

TY - JOUR

T1 - Dopamine markers and general cognitive ability

AU - Ball, D

AU - Hill, L

AU - Eley, T C

AU - Chorney, M J

AU - Chorney, K

AU - Thompson, L A

AU - Detterman, D K

AU - Benbow, C

AU - Lubinski, D

AU - Owen, M

AU - McGuffin, P

AU - Plomin, R

PY - 1998/1/26

Y1 - 1998/1/26

N2 - Because general cognitive ability (g) is among the most heritable behavioural traits, it is a reasonable target for a search for quantitative trait loci (QTLs). We used a selected-extremes design to test candidate genes for allelic association with g. Polymorphisms in four genes in the dopamine system (DRD2, DRD3, DRD4, DAT1) were genotyped for 51 high g children with IQ scores > 130 and for 51 average g control children. No significant allelic or genotypic differences were found between the high g and average g groups for these markers of the dopamine system, even though the selected-extremes design provides power to detect QTL associations that involve a relative risk of about 1.5.

AB - Because general cognitive ability (g) is among the most heritable behavioural traits, it is a reasonable target for a search for quantitative trait loci (QTLs). We used a selected-extremes design to test candidate genes for allelic association with g. Polymorphisms in four genes in the dopamine system (DRD2, DRD3, DRD4, DAT1) were genotyped for 51 high g children with IQ scores > 130 and for 51 average g control children. No significant allelic or genotypic differences were found between the high g and average g groups for these markers of the dopamine system, even though the selected-extremes design provides power to detect QTL associations that involve a relative risk of about 1.5.

U2 - 10.1097/00001756-199801260-00031

DO - 10.1097/00001756-199801260-00031

M3 - Article

C2 - 9507981

SN - 0959-4965

VL - 9

SP - 347

EP - 349

JO - Neuroreport

JF - Neuroreport

IS - 2

ER -