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Dopamine, Prediction Error and beyond

Research output: Contribution to journalArticle

Kelly Diederen, Paul Fletcher

Original languageEnglish
Pages (from-to)1-17
Number of pages17
JournalNEUROSCIENTIST
DOIs
Publication statusPublished - 26 Apr 2020

King's Authors

Abstract

A large body of work has linked dopaminergic signalling to learning and reward processing. It stresses the role of dopamine in reward prediction error signalling, a key neural signal that allows us to learn from past experiences, and that facilitates optimal choice behaviour. Latterly, it has become clear that dopamine does not merely code prediction error size but also signals the difference between the expected value of rewards, and the value of rewards actually received, which is obtained through the integration of reward attributes such as the type, amount, probability and delay. More recent work has posited a role of dopamine in learning beyond rewards. These theories suggest that dopamine codes absolute or unsigned prediction errors, playing a key role in how the brain models associative regularities within its environment, while incorporating critical information about the reliability of those regularities. Work is emerging supporting this perspective and, it has inspired theoretical models of how certain forms of mental pathology may emerge in relation to dopamine function. Such pathology is frequently related to disturbed inferences leading to altered internal models of the environment. Thus, it is critical to understand the role of dopamine in error-related learning and inference.

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