Double-dissociation between the mechanism leading to impulsivity and inattention in Attention Deficit Hyperactivity Disorder: A resting-state functional connectivity study

Masafumi Sanefuji; Michael Craig; Valeria Parlatini; Mitul A. Mehta; Declan G. Murphy; Marco Catani; Leonardo Cerliani; Michel Thiebaut de Schotten

doi:10.1016/j.cortex.2016.06.005

Double-dissociation between the mechanism leading to impulsivity and inattention in Attention Deficit Hyperactivity Disorder: A resting-state functional connectivity study

Masafumi Sanefuji, Michael Craig, Valeria Parlatini, Mitul A. Mehta, Declan G. Murphy, Marco Catani, Leonardo Cerliani, Michel Thiebaut de Schotten^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

44 Citations (Scopus)

359 Downloads (Pure)

Abstract

Two core symptoms characterize Attention Deficit Hyperactivity Disorder (ADHD) subtypes: inattentiveness and hyperactivity-impulsivity. While previous brain imaging research investigated ADHD as if it was a homogenous condition, its two core symptoms may originate from different brain mechanisms. We, therefore, hypothesized that the functional connectivity of cortico-striatal and attentional networks would be different between ADHD subtypes. We studied 165 children (mean age 10.93 years; age range, 7-17 year old) diagnosed as having ADHD based on their revised Conner's rating scale score and 170 typical developing individuals (mean age 11.46 years; age range, 7-17 year old) using resting state functional fMRI. Groups were matched for age, IQ and head motion during the MRI acquisition. We fractionated the ADHD group into predominantly inattentive, hyperactive-impulsive and combined subtypes based on their revised Conner's rating scale score. We then analyzed differences in resting state functional connectivity of the cortico-striatal and attentional networks between these subtypes. We found a double dissociation of functional connectivity in the cortico-striatal and ventral attentional networks, reflecting the subtypes of the ADHD participants. Particularly, the hyperactive-impulsive subtype was associated with increased connectivity in cortico-striatal network, whereas the inattentive subtype was associated with increased connectivity in the right ventral attention network. Our study demonstrated for the first time a right lateralized, double dissociation between specific networks associated with hyperactivity-impulsivity and inattentiveness in ADHD children, providing a biological basis for exploring symptom dimensions and revealing potential targets for more personalized treatments.

Original language	English
Pages (from-to)	290-302
Journal	Cortex
Volume	86
Issue number	0
Early online date	16 Jun 2016
DOIs	https://doi.org/10.1016/j.cortex.2016.06.005
Publication status	Published - 1 Jan 2017

Keywords

ADHD subtypes
functional connectivity
inter-individual variability
fronto-parietal
cortico-striatal

Access to Document

10.1016/j.cortex.2016.06.005

Double-Dissociation between the mechanism_SANEFUJI_Accepted 6Jun2016_GREEN AAM
© 2016. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
Accepted author manuscript, 4.92 MBLicence: CC BY-NC-ND

Cite this

Sanefuji, M., Craig, M., Parlatini, V., Mehta, M. A., Murphy, D. G., Catani, M., Cerliani, L., & Thiebaut de Schotten, M. (2017). Double-dissociation between the mechanism leading to impulsivity and inattention in Attention Deficit Hyperactivity Disorder: A resting-state functional connectivity study. Cortex, 86(0), 290-302. https://doi.org/10.1016/j.cortex.2016.06.005

@article{ccb3c5b5ad0b4a59b1eb5951baf6537b,

title = "Double-dissociation between the mechanism leading to impulsivity and inattention in Attention Deficit Hyperactivity Disorder: A resting-state functional connectivity study",

abstract = "Two core symptoms characterize Attention Deficit Hyperactivity Disorder (ADHD) subtypes: inattentiveness and hyperactivity-impulsivity. While previous brain imaging research investigated ADHD as if it was a homogenous condition, its two core symptoms may originate from different brain mechanisms. We, therefore, hypothesized that the functional connectivity of cortico-striatal and attentional networks would be different between ADHD subtypes. We studied 165 children (mean age 10.93 years; age range, 7-17 year old) diagnosed as having ADHD based on their revised Conner's rating scale score and 170 typical developing individuals (mean age 11.46 years; age range, 7-17 year old) using resting state functional fMRI. Groups were matched for age, IQ and head motion during the MRI acquisition. We fractionated the ADHD group into predominantly inattentive, hyperactive-impulsive and combined subtypes based on their revised Conner's rating scale score. We then analyzed differences in resting state functional connectivity of the cortico-striatal and attentional networks between these subtypes. We found a double dissociation of functional connectivity in the cortico-striatal and ventral attentional networks, reflecting the subtypes of the ADHD participants. Particularly, the hyperactive-impulsive subtype was associated with increased connectivity in cortico-striatal network, whereas the inattentive subtype was associated with increased connectivity in the right ventral attention network. Our study demonstrated for the first time a right lateralized, double dissociation between specific networks associated with hyperactivity-impulsivity and inattentiveness in ADHD children, providing a biological basis for exploring symptom dimensions and revealing potential targets for more personalized treatments.",

keywords = "ADHD subtypes, functional connectivity, inter-individual variability, fronto-parietal, cortico-striatal",

author = "Masafumi Sanefuji and Michael Craig and Valeria Parlatini and Mehta, {Mitul A.} and Murphy, {Declan G.} and Marco Catani and Leonardo Cerliani and {Thiebaut de Schotten}, Michel",

year = "2017",

month = jan,

day = "1",

doi = "10.1016/j.cortex.2016.06.005",

language = "English",

volume = "86",

pages = "290--302",

journal = "Cortex",

issn = "0010-9452",

publisher = "Elsevier Masson",

number = "0",

}

Sanefuji, M, Craig, M , Parlatini, V , Mehta, MA , Murphy, DG, Catani, M, Cerliani, L & Thiebaut de Schotten, M 2017, 'Double-dissociation between the mechanism leading to impulsivity and inattention in Attention Deficit Hyperactivity Disorder: A resting-state functional connectivity study', Cortex, vol. 86, no. 0, pp. 290-302. https://doi.org/10.1016/j.cortex.2016.06.005

TY - JOUR

T1 - Double-dissociation between the mechanism leading to impulsivity and inattention in Attention Deficit Hyperactivity Disorder

T2 - A resting-state functional connectivity study

AU - Sanefuji, Masafumi

AU - Craig, Michael

AU - Parlatini, Valeria

AU - Mehta, Mitul A.

AU - Murphy, Declan G.

AU - Catani, Marco

AU - Cerliani, Leonardo

AU - Thiebaut de Schotten, Michel

PY - 2017/1/1

Y1 - 2017/1/1

N2 - Two core symptoms characterize Attention Deficit Hyperactivity Disorder (ADHD) subtypes: inattentiveness and hyperactivity-impulsivity. While previous brain imaging research investigated ADHD as if it was a homogenous condition, its two core symptoms may originate from different brain mechanisms. We, therefore, hypothesized that the functional connectivity of cortico-striatal and attentional networks would be different between ADHD subtypes. We studied 165 children (mean age 10.93 years; age range, 7-17 year old) diagnosed as having ADHD based on their revised Conner's rating scale score and 170 typical developing individuals (mean age 11.46 years; age range, 7-17 year old) using resting state functional fMRI. Groups were matched for age, IQ and head motion during the MRI acquisition. We fractionated the ADHD group into predominantly inattentive, hyperactive-impulsive and combined subtypes based on their revised Conner's rating scale score. We then analyzed differences in resting state functional connectivity of the cortico-striatal and attentional networks between these subtypes. We found a double dissociation of functional connectivity in the cortico-striatal and ventral attentional networks, reflecting the subtypes of the ADHD participants. Particularly, the hyperactive-impulsive subtype was associated with increased connectivity in cortico-striatal network, whereas the inattentive subtype was associated with increased connectivity in the right ventral attention network. Our study demonstrated for the first time a right lateralized, double dissociation between specific networks associated with hyperactivity-impulsivity and inattentiveness in ADHD children, providing a biological basis for exploring symptom dimensions and revealing potential targets for more personalized treatments.

AB - Two core symptoms characterize Attention Deficit Hyperactivity Disorder (ADHD) subtypes: inattentiveness and hyperactivity-impulsivity. While previous brain imaging research investigated ADHD as if it was a homogenous condition, its two core symptoms may originate from different brain mechanisms. We, therefore, hypothesized that the functional connectivity of cortico-striatal and attentional networks would be different between ADHD subtypes. We studied 165 children (mean age 10.93 years; age range, 7-17 year old) diagnosed as having ADHD based on their revised Conner's rating scale score and 170 typical developing individuals (mean age 11.46 years; age range, 7-17 year old) using resting state functional fMRI. Groups were matched for age, IQ and head motion during the MRI acquisition. We fractionated the ADHD group into predominantly inattentive, hyperactive-impulsive and combined subtypes based on their revised Conner's rating scale score. We then analyzed differences in resting state functional connectivity of the cortico-striatal and attentional networks between these subtypes. We found a double dissociation of functional connectivity in the cortico-striatal and ventral attentional networks, reflecting the subtypes of the ADHD participants. Particularly, the hyperactive-impulsive subtype was associated with increased connectivity in cortico-striatal network, whereas the inattentive subtype was associated with increased connectivity in the right ventral attention network. Our study demonstrated for the first time a right lateralized, double dissociation between specific networks associated with hyperactivity-impulsivity and inattentiveness in ADHD children, providing a biological basis for exploring symptom dimensions and revealing potential targets for more personalized treatments.

KW - ADHD subtypes

KW - functional connectivity

KW - inter-individual variability

KW - fronto-parietal

KW - cortico-striatal

UR - http://www.scopus.com/inward/record.url?scp=84979680201&partnerID=8YFLogxK

U2 - 10.1016/j.cortex.2016.06.005

DO - 10.1016/j.cortex.2016.06.005

M3 - Article

SN - 0010-9452

VL - 86

SP - 290

EP - 302

JO - Cortex

JF - Cortex

IS - 0

ER -

Double-dissociation between the mechanism leading to impulsivity and inattention in Attention Deficit Hyperactivity Disorder: A resting-state functional connectivity study

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this