Drinking water disinfection by-products, genetic polymorphisms, and birth outcomes in a european mother-child cohort study

Manolis Kogevinas; Mariona Bustamante; Esther Gracia-Lavedán; Ferran Ballester; Sylvaine Cordier; Nathalie Costet; Ana Espinosa; Regina Grazuleviciene; Asta Danileviciute; Jesus Ibarluzea; Maria Karadanelli; Stuart Krasner; Evridiki Patelarou; Euripides Stephanou; Adonina Tardón; Mireille B. Toledano; John Wright; Cristina M. Villanueva; Mark Nieuwenhuijsen

doi:10.1097/EDE.0000000000000544

Drinking water disinfection by-products, genetic polymorphisms, and birth outcomes in a european mother-child cohort study

Manolis Kogevinas^*, Mariona Bustamante, Esther Gracia-Lavedán, Ferran Ballester, Sylvaine Cordier, Nathalie Costet, Ana Espinosa, Regina Grazuleviciene, Asta Danileviciute, Jesus Ibarluzea, Maria Karadanelli, Stuart Krasner, Evridiki Patelarou, Euripides Stephanou, Adonina Tardón, Mireille B. Toledano, John Wright, Cristina M. Villanueva, Mark Nieuwenhuijsen

^*Corresponding author for this work

Child & Family Health Nursing

Research output: Contribution to journal › Article › peer-review

27 Citations (Scopus)

Abstract

Background: We examined the association between exposure during pregnancy to trihalomethanes, the most common water disinfection by-products, and birth outcomes in a European cohort study (Health Impacts of Long-Term Exposure to Disinfection By-Products in Drinking Water). We took into account exposure through different water uses, measures of water toxicity, and genetic susceptibility. Methods: We enrolled 14,005 mothers (2002-2010) and their children from France, Greece, Lithuania, Spain, and the UK. Information on lifestyle- and water-related activities was recorded. We ascertained residential concentrations of trihalomethanes through regulatory records and ad hoc sampling campaigns and estimated route-specific trihalomethane uptake by trimester and for whole pregnancy. We examined single nucleotide polymorphisms and copy number variants in disinfection by-product metabolizing genes in nested case-control studies. Results: Average levels of trihalomethanes ranged from around 10 μg/L to above the regulatory limits in the EU of 100 μg/L between centers. There was no association between birth weight and total trihalomethane exposure during pregnancy (β = 2.2 g in birth weight per 10 μg/L of trihalomethane, 95% confidence interval = 3.3, 7.6). Birth weight was not associated with exposure through different routes or with specific trihalomethane species. Exposure to trihalomethanes was not associated with low birth weight (odds ratio [OR] per 10 μg/L = 1.02, 95% confidence interval = 0.95, 1.10), small-for-gestational age (OR = 0.99, 0.94, 1.03) and preterm births (OR = 0.98, 0.9, 1.05). We found no gene-environment interactions for mother or child polymorphisms in relation to preterm birth or small-for-gestational age. Conclusions: In this large European study, we found no association between birth outcomes and trihalomethane exposures during pregnancy in the total population or in potentially genetically susceptible subgroups.

Original language	English
Pages (from-to)	903-911
Number of pages	9
Journal	Epidemiology
Volume	27
Issue number	6
DOIs	https://doi.org/10.1097/EDE.0000000000000544
Publication status	Published - 1 Nov 2016

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10.1097/EDE.0000000000000544

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Kogevinas, M., Bustamante, M., Gracia-Lavedán, E., Ballester, F., Cordier, S., Costet, N., Espinosa, A., Grazuleviciene, R., Danileviciute, A., Ibarluzea, J., Karadanelli, M., Krasner, S., Patelarou, E., Stephanou, E., Tardón, A., Toledano, M. B., Wright, J., Villanueva, C. M., & Nieuwenhuijsen, M. (2016). Drinking water disinfection by-products, genetic polymorphisms, and birth outcomes in a european mother-child cohort study. Epidemiology, 27(6), 903-911. https://doi.org/10.1097/EDE.0000000000000544

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title = "Drinking water disinfection by-products, genetic polymorphisms, and birth outcomes in a european mother-child cohort study",

abstract = "Background: We examined the association between exposure during pregnancy to trihalomethanes, the most common water disinfection by-products, and birth outcomes in a European cohort study (Health Impacts of Long-Term Exposure to Disinfection By-Products in Drinking Water). We took into account exposure through different water uses, measures of water toxicity, and genetic susceptibility. Methods: We enrolled 14,005 mothers (2002-2010) and their children from France, Greece, Lithuania, Spain, and the UK. Information on lifestyle- and water-related activities was recorded. We ascertained residential concentrations of trihalomethanes through regulatory records and ad hoc sampling campaigns and estimated route-specific trihalomethane uptake by trimester and for whole pregnancy. We examined single nucleotide polymorphisms and copy number variants in disinfection by-product metabolizing genes in nested case-control studies. Results: Average levels of trihalomethanes ranged from around 10 μg/L to above the regulatory limits in the EU of 100 μg/L between centers. There was no association between birth weight and total trihalomethane exposure during pregnancy (β = 2.2 g in birth weight per 10 μg/L of trihalomethane, 95% confidence interval = 3.3, 7.6). Birth weight was not associated with exposure through different routes or with specific trihalomethane species. Exposure to trihalomethanes was not associated with low birth weight (odds ratio [OR] per 10 μg/L = 1.02, 95% confidence interval = 0.95, 1.10), small-for-gestational age (OR = 0.99, 0.94, 1.03) and preterm births (OR = 0.98, 0.9, 1.05). We found no gene-environment interactions for mother or child polymorphisms in relation to preterm birth or small-for-gestational age. Conclusions: In this large European study, we found no association between birth outcomes and trihalomethane exposures during pregnancy in the total population or in potentially genetically susceptible subgroups.",

author = "Manolis Kogevinas and Mariona Bustamante and Esther Gracia-Laved{\'a}n and Ferran Ballester and Sylvaine Cordier and Nathalie Costet and Ana Espinosa and Regina Grazuleviciene and Asta Danileviciute and Jesus Ibarluzea and Maria Karadanelli and Stuart Krasner and Evridiki Patelarou and Euripides Stephanou and Adonina Tard{\'o}n and Toledano, {Mireille B.} and John Wright and Villanueva, {Cristina M.} and Mark Nieuwenhuijsen",

year = "2016",

month = nov,

day = "1",

doi = "10.1097/EDE.0000000000000544",

language = "English",

volume = "27",

pages = "903--911",

journal = "Epidemiology",

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publisher = "LIPPINCOTT WILLIAMS & WILKINS",

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Kogevinas, M, Bustamante, M, Gracia-Lavedán, E, Ballester, F, Cordier, S, Costet, N, Espinosa, A, Grazuleviciene, R, Danileviciute, A, Ibarluzea, J, Karadanelli, M, Krasner, S, Patelarou, E, Stephanou, E, Tardón, A, Toledano, MB, Wright, J, Villanueva, CM & Nieuwenhuijsen, M 2016, 'Drinking water disinfection by-products, genetic polymorphisms, and birth outcomes in a european mother-child cohort study', Epidemiology, vol. 27, no. 6, pp. 903-911. https://doi.org/10.1097/EDE.0000000000000544

TY - JOUR

T1 - Drinking water disinfection by-products, genetic polymorphisms, and birth outcomes in a european mother-child cohort study

AU - Kogevinas, Manolis

AU - Bustamante, Mariona

AU - Gracia-Lavedán, Esther

AU - Ballester, Ferran

AU - Cordier, Sylvaine

AU - Costet, Nathalie

AU - Espinosa, Ana

AU - Grazuleviciene, Regina

AU - Danileviciute, Asta

AU - Ibarluzea, Jesus

AU - Karadanelli, Maria

AU - Krasner, Stuart

AU - Patelarou, Evridiki

AU - Stephanou, Euripides

AU - Tardón, Adonina

AU - Toledano, Mireille B.

AU - Wright, John

AU - Villanueva, Cristina M.

AU - Nieuwenhuijsen, Mark

PY - 2016/11/1

Y1 - 2016/11/1

N2 - Background: We examined the association between exposure during pregnancy to trihalomethanes, the most common water disinfection by-products, and birth outcomes in a European cohort study (Health Impacts of Long-Term Exposure to Disinfection By-Products in Drinking Water). We took into account exposure through different water uses, measures of water toxicity, and genetic susceptibility. Methods: We enrolled 14,005 mothers (2002-2010) and their children from France, Greece, Lithuania, Spain, and the UK. Information on lifestyle- and water-related activities was recorded. We ascertained residential concentrations of trihalomethanes through regulatory records and ad hoc sampling campaigns and estimated route-specific trihalomethane uptake by trimester and for whole pregnancy. We examined single nucleotide polymorphisms and copy number variants in disinfection by-product metabolizing genes in nested case-control studies. Results: Average levels of trihalomethanes ranged from around 10 μg/L to above the regulatory limits in the EU of 100 μg/L between centers. There was no association between birth weight and total trihalomethane exposure during pregnancy (β = 2.2 g in birth weight per 10 μg/L of trihalomethane, 95% confidence interval = 3.3, 7.6). Birth weight was not associated with exposure through different routes or with specific trihalomethane species. Exposure to trihalomethanes was not associated with low birth weight (odds ratio [OR] per 10 μg/L = 1.02, 95% confidence interval = 0.95, 1.10), small-for-gestational age (OR = 0.99, 0.94, 1.03) and preterm births (OR = 0.98, 0.9, 1.05). We found no gene-environment interactions for mother or child polymorphisms in relation to preterm birth or small-for-gestational age. Conclusions: In this large European study, we found no association between birth outcomes and trihalomethane exposures during pregnancy in the total population or in potentially genetically susceptible subgroups.

AB - Background: We examined the association between exposure during pregnancy to trihalomethanes, the most common water disinfection by-products, and birth outcomes in a European cohort study (Health Impacts of Long-Term Exposure to Disinfection By-Products in Drinking Water). We took into account exposure through different water uses, measures of water toxicity, and genetic susceptibility. Methods: We enrolled 14,005 mothers (2002-2010) and their children from France, Greece, Lithuania, Spain, and the UK. Information on lifestyle- and water-related activities was recorded. We ascertained residential concentrations of trihalomethanes through regulatory records and ad hoc sampling campaigns and estimated route-specific trihalomethane uptake by trimester and for whole pregnancy. We examined single nucleotide polymorphisms and copy number variants in disinfection by-product metabolizing genes in nested case-control studies. Results: Average levels of trihalomethanes ranged from around 10 μg/L to above the regulatory limits in the EU of 100 μg/L between centers. There was no association between birth weight and total trihalomethane exposure during pregnancy (β = 2.2 g in birth weight per 10 μg/L of trihalomethane, 95% confidence interval = 3.3, 7.6). Birth weight was not associated with exposure through different routes or with specific trihalomethane species. Exposure to trihalomethanes was not associated with low birth weight (odds ratio [OR] per 10 μg/L = 1.02, 95% confidence interval = 0.95, 1.10), small-for-gestational age (OR = 0.99, 0.94, 1.03) and preterm births (OR = 0.98, 0.9, 1.05). We found no gene-environment interactions for mother or child polymorphisms in relation to preterm birth or small-for-gestational age. Conclusions: In this large European study, we found no association between birth outcomes and trihalomethane exposures during pregnancy in the total population or in potentially genetically susceptible subgroups.

UR - http://www.scopus.com/inward/record.url?scp=84979971049&partnerID=8YFLogxK

U2 - 10.1097/EDE.0000000000000544

DO - 10.1097/EDE.0000000000000544

M3 - Article

AN - SCOPUS:84979971049

SN - 1044-3983

VL - 27

SP - 903

EP - 911

JO - Epidemiology

JF - Epidemiology

IS - 6

ER -

Drinking water disinfection by-products, genetic polymorphisms, and birth outcomes in a european mother-child cohort study

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