Drug Targetor: a web interface to investigate the human druggome for over 500 phenotypes

TY - JOUR

T1 - Drug Targetor

T2 - a web interface to investigate the human druggome for over 500 phenotypes

AU - Gaspar, Héléna A

AU - Hübel, Christopher

AU - Breen, Gerome

PY - 2018/12/4

Y1 - 2018/12/4

N2 - Summary: Results from hundreds of genome-wide association studies (GWAS) are now freely available and offer a catalogue of the association between phenotypes across medicine with variants in the genome. With the aim of using this data to better understand therapeutic mechanisms, we have developed Drug Targetor, a web interface that allows the generation and exploration of drug-target networks of hundreds of phenotypes using GWAS data. Drug Targetor networks consist of drug and target nodes ordered by genetic association and connected by drug-target or drug-gene relationship. We show that Drug Targetor can help prioritize drugs, targets and drug-target interactions for a specific phenotype based on genetic evidence.Availability and implementation: Drug Targetor v1.21 is a web application freely available online at drugtargetor.com and under MIT license. The source code can be found at https://github.com/hagax8/drugtargetor.Supplementary information: Supplementary data are available at Bioinformatics online.

AB - Summary: Results from hundreds of genome-wide association studies (GWAS) are now freely available and offer a catalogue of the association between phenotypes across medicine with variants in the genome. With the aim of using this data to better understand therapeutic mechanisms, we have developed Drug Targetor, a web interface that allows the generation and exploration of drug-target networks of hundreds of phenotypes using GWAS data. Drug Targetor networks consist of drug and target nodes ordered by genetic association and connected by drug-target or drug-gene relationship. We show that Drug Targetor can help prioritize drugs, targets and drug-target interactions for a specific phenotype based on genetic evidence.Availability and implementation: Drug Targetor v1.21 is a web application freely available online at drugtargetor.com and under MIT license. The source code can be found at https://github.com/hagax8/drugtargetor.Supplementary information: Supplementary data are available at Bioinformatics online.

U2 - 10.1093/bioinformatics/bty982

DO - 10.1093/bioinformatics/bty982

M3 - Article

C2 - 30517594

SN - 1367-4811

JO - Bioinformatics (Oxford, England)

JF - Bioinformatics (Oxford, England)

ER -