Dual Cognitive and Biological Correlates of Anxiety in Autism Spectrum Disorders

Matthew Hollocks; Andrew Pickles; Patricia Howlin; Emily Simonoff

doi:10.1007/s10803-016-2878-2

Dual Cognitive and Biological Correlates of Anxiety in Autism Spectrum Disorders

Matthew Hollocks, Andrew Pickles, Patricia Howlin, Emily Simonoff

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Abstract

Young people with autism spectrum disorder (ASD) have a high prevalence (~40%) of anxiety disorders compared to their non-ASD peers. It is unclear whether cognitive and biological processes associated with anxiety in ASD are analogous to anxiety in typically developing (TD) populations. In this study 55 boys with ASD (34 with a cooccurring anxiety disorder, 21 without) and 28 male controls, aged 10 16 years and with a full-scale IQ ≥70, completed a series of clinical, cognitive (attention bias/interpretation bias) and biological measures (salivary cortisol/HR response to social stress) associated with anxiety in TD populations. Structural equation modelling (SEM) was used to reveal that that both attentional biases and physiological responsiveness were significant, but unrelated, predictors of anxiety in ASD

Original language	English
Pages (from-to)	3295–3307
Number of pages	13
Journal	Journal of autism and developmental disorders
Volume	46
Issue number	10
Early online date	27 Jul 2016
DOIs	https://doi.org/10.1007/s10803-016-2878-2
Publication status	E-pub ahead of print - 27 Jul 2016

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Dual Cognitive and Biological_HOLLOCKS_AcceptedJuly2016_GREEN AAMAccepted author manuscript, 1.28 MB

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abstract = "Young people with autism spectrum disorder (ASD) have a high prevalence (~40%) of anxiety disorders compared to their non-ASD peers. It is unclear whether cognitive and biological processes associated with anxiety in ASD are analogous to anxiety in typically developing (TD) populations. In this study 55 boys with ASD (34 with a cooccurring anxiety disorder, 21 without) and 28 male controls, aged 10 16 years and with a full-scale IQ ≥70, completed a series of clinical, cognitive (attention bias/interpretation bias) and biological measures (salivary cortisol/HR response to social stress) associated with anxiety in TD populations. Structural equation modelling (SEM) was used to reveal that that both attentional biases and physiological responsiveness were significant, but unrelated, predictors of anxiety in ASD",

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AB - Young people with autism spectrum disorder (ASD) have a high prevalence (~40%) of anxiety disorders compared to their non-ASD peers. It is unclear whether cognitive and biological processes associated with anxiety in ASD are analogous to anxiety in typically developing (TD) populations. In this study 55 boys with ASD (34 with a cooccurring anxiety disorder, 21 without) and 28 male controls, aged 10 16 years and with a full-scale IQ ≥70, completed a series of clinical, cognitive (attention bias/interpretation bias) and biological measures (salivary cortisol/HR response to social stress) associated with anxiety in TD populations. Structural equation modelling (SEM) was used to reveal that that both attentional biases and physiological responsiveness were significant, but unrelated, predictors of anxiety in ASD

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Dual Cognitive and Biological Correlates of Anxiety in Autism Spectrum Disorders

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