Dual Selective Iron Chelating Probes with a Potential to Monitor Mitochondrial Labile Iron Pools

Vincenzo Abbate; Olivier Sylvian Reelfs; Xiaole Kong; Charareh Pourzand; Robert Hider

doi:10.1039/C5CC06170A

Dual Selective Iron Chelating Probes with a Potential to Monitor Mitochondrial Labile Iron Pools

Vincenzo Abbate, Olivier Sylvian Reelfs, Xiaole Kong, Charareh Pourzand, Robert Hider

Research output: Contribution to journal › Article › peer-review

24 Citations (Scopus)

Abstract

Mitochondria-targeted peptides incorporating dual fluorescent and selective iron chelators have been designed as novel biosensors for the mitochondrial labile iron pool. The probes were demonstrated to specifically co-localize with mitochondria and their fluorescence emission was found to be sensitive to the presence of iron.

Original language	English
Pages (from-to)	784-787
Journal	CHEMICAL COMMUNICATIONS- ROYAL SOCIETY OF CHEMISTRY
Volume	52
DOIs	https://doi.org/10.1039/C5CC06170A
Publication status	Published - 9 Nov 2015

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title = "Dual Selective Iron Chelating Probes with a Potential to Monitor Mitochondrial Labile Iron Pools",

abstract = "Mitochondria-targeted peptides incorporating dual fluorescent and selective iron chelators have been designed as novel biosensors for the mitochondrial labile iron pool. The probes were demonstrated to specifically co-localize with mitochondria and their fluorescence emission was found to be sensitive to the presence of iron.",

author = "Vincenzo Abbate and Reelfs, {Olivier Sylvian} and Xiaole Kong and Charareh Pourzand and Robert Hider",

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AU - Abbate, Vincenzo

AU - Reelfs, Olivier Sylvian

AU - Kong, Xiaole

AU - Pourzand, Charareh

AU - Hider, Robert

PY - 2015/11/9

Y1 - 2015/11/9

N2 - Mitochondria-targeted peptides incorporating dual fluorescent and selective iron chelators have been designed as novel biosensors for the mitochondrial labile iron pool. The probes were demonstrated to specifically co-localize with mitochondria and their fluorescence emission was found to be sensitive to the presence of iron.

AB - Mitochondria-targeted peptides incorporating dual fluorescent and selective iron chelators have been designed as novel biosensors for the mitochondrial labile iron pool. The probes were demonstrated to specifically co-localize with mitochondria and their fluorescence emission was found to be sensitive to the presence of iron.

UR - http://pubs.rsc.org/en/content/articlelanding/2014/CC/C5CC06170A#!divAbstract

U2 - 10.1039/C5CC06170A

DO - 10.1039/C5CC06170A

M3 - Article

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VL - 52

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JO - CHEMICAL COMMUNICATIONS- ROYAL SOCIETY OF CHEMISTRY

JF - CHEMICAL COMMUNICATIONS- ROYAL SOCIETY OF CHEMISTRY

ER -

Dual Selective Iron Chelating Probes with a Potential to Monitor Mitochondrial Labile Iron Pools

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