Duration of prodromal phase and severity of volumetric abnormalities in first-episode psychosis

TY - JOUR

T1 - Duration of prodromal phase and severity of volumetric abnormalities in first-episode psychosis

AU - Lappin, J M

AU - Dazzan, P

AU - Morgan, K

AU - Morgan, C

AU - Chitnis, X

AU - Suckling, J

AU - Fearon, P

AU - Jones, P B

AU - Leff, J

AU - Murrayand, R M

AU - McGuire, P K

PY - 2007/12

Y1 - 2007/12

N2 - Background First-episode psychosis is typically preceded by a prodrome in which there is deterioration in global and social functioning. Aims To examine whether the duration of the prodromal phase influences grey and white matter volumes at the onset of psychosis. Methods Eighty-two people were scanned using magnetic resonance imaging when they developed a first episode of psychosis, The duration of the prodromal phase was estimated from detailed interviews and medical records.Voxel-based morphometry was used to assess neuroanatomical abnormalities. Results A long prodromal phase was associated with smaller grey matter volumes in the cingulate, frontal and left insular cortex, and with less white matter volume bilaterally in the superior longitudinal and uncinate fasciculi and the cingulum. Conclusions The severity of volumetric abnormalities in first-episode psychosis was greater in those with a long prodrome. Declaration of interest None. Funding detailed in Acknowledgements

AB - Background First-episode psychosis is typically preceded by a prodrome in which there is deterioration in global and social functioning. Aims To examine whether the duration of the prodromal phase influences grey and white matter volumes at the onset of psychosis. Methods Eighty-two people were scanned using magnetic resonance imaging when they developed a first episode of psychosis, The duration of the prodromal phase was estimated from detailed interviews and medical records.Voxel-based morphometry was used to assess neuroanatomical abnormalities. Results A long prodromal phase was associated with smaller grey matter volumes in the cingulate, frontal and left insular cortex, and with less white matter volume bilaterally in the superior longitudinal and uncinate fasciculi and the cingulum. Conclusions The severity of volumetric abnormalities in first-episode psychosis was greater in those with a long prodrome. Declaration of interest None. Funding detailed in Acknowledgements

U2 - 10.1192/bjp.191.51.s123

DO - 10.1192/bjp.191.51.s123

M3 - Article

SN - 1472-1465

VL - 191

SP - S123 - S127

JO - British Journal of Psychiatry

JF - British Journal of Psychiatry

IS - SUPPL. 51

ER -