Dynamic, adaptive changes in MAO-A binding after alterations in substrate availability: an in vivo [(11)C]-harmine positron emission tomography study

TY - JOUR

T1 - Dynamic, adaptive changes in MAO-A binding after alterations in substrate availability

T2 - an in vivo [(11)C]-harmine positron emission tomography study

AU - Sacher, Julia

AU - Rabiner, Eugenii A

AU - Clark, Michael

AU - Rusjan, Pablo

AU - Soliman, Alexandra

AU - Boskovic, Rada

AU - Kish, Stephen J

AU - Wilson, Alan A

AU - Houle, Sylvain

AU - Meyer, Jeffrey H

PY - 2012

Y1 - 2012

N2 - Monoamine oxidase A (MAO-A) is an important target in the pathophysiology and therapeutics of major depressive disorder, aggression, and neurodegenerative conditions. We measured the effect of changes in MAO-A substrate on MAO-A binding in regions implicated in affective and neurodegenerative disease with [11C]-harmine positron emission tomography in healthy volunteers. Monoamine oxidase A VT, an index of MAO-A density, was decreased (mean: 14%±9%) following tryptophan depletion in prefrontal cortex (P<0.031), and elevated (mean: 17%±11%) in striatum following carbidopa–levodopa administration (P<0.007). These findings suggest an adaptive role for MAO-A in maintaining monoamine neurotransmitter homeostasis by rapidly compensating fluctuating monoamine levels.

AB - Monoamine oxidase A (MAO-A) is an important target in the pathophysiology and therapeutics of major depressive disorder, aggression, and neurodegenerative conditions. We measured the effect of changes in MAO-A substrate on MAO-A binding in regions implicated in affective and neurodegenerative disease with [11C]-harmine positron emission tomography in healthy volunteers. Monoamine oxidase A VT, an index of MAO-A density, was decreased (mean: 14%±9%) following tryptophan depletion in prefrontal cortex (P<0.031), and elevated (mean: 17%±11%) in striatum following carbidopa–levodopa administration (P<0.007). These findings suggest an adaptive role for MAO-A in maintaining monoamine neurotransmitter homeostasis by rapidly compensating fluctuating monoamine levels.

U2 - 10.1038/jcbfm.2011.184

DO - 10.1038/jcbfm.2011.184

M3 - Article

C2 - 22186668

SN - 1559-7016

VL - 32

SP - 443

EP - 446

JO - Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism

JF - Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism

IS - 3

ER -