Dynamic expression of neurexophilin1 during zebrafish embryonic development

TY - JOUR

T1 - Dynamic expression of neurexophilin1 during zebrafish embryonic development

AU - Thomas, Swapna

AU - Houart, Corinne

N1 - Copyright © 2013 The Authors. Published by Elsevier B.V. All rights reserved.

PY - 2013

Y1 - 2013

N2 - Neurexophilin 1 (Nxph1) is a specific endoligand of α-neurexins that is essential for trans-synaptic activation. Here, we report its dynamic expression during development in zebrafish. Our study revealed an early onset of expression of nxph1. RT-PCR on a series of embryonic stages showed that it is maternally deposited, although only readily detectable by whole mount in situ hybridization by 22hpf. During embryogenesis and larval stages, the zygotic transcript is expressed dynamically in various clusters of post-mitotic neurons and in glia in the central nervous system.

AB - Neurexophilin 1 (Nxph1) is a specific endoligand of α-neurexins that is essential for trans-synaptic activation. Here, we report its dynamic expression during development in zebrafish. Our study revealed an early onset of expression of nxph1. RT-PCR on a series of embryonic stages showed that it is maternally deposited, although only readily detectable by whole mount in situ hybridization by 22hpf. During embryogenesis and larval stages, the zygotic transcript is expressed dynamically in various clusters of post-mitotic neurons and in glia in the central nervous system.

U2 - 10.1016/j.gep.2013.07.006

DO - 10.1016/j.gep.2013.07.006

M3 - Article

C2 - 23880144

SN - 1567-133X

VL - 13

SP - 395

EP - 401

JO - Gene Expression Patterns

JF - Gene Expression Patterns

IS - 8

ER -