Dynamic imaging for CAR-T-cell therapy

Nia Emami-Shahri; Sophie Papa

doi:10.1042/BST20150257

Dynamic imaging for CAR-T-cell therapy

Nia Emami-Shahri, Sophie Papa^*

^*Corresponding author for this work

Comprehensive Cancer Centre

Research output: Contribution to journal › Article › peer-review

12 Citations (Scopus)

Abstract

Chimaeric antigen receptor (CAR) therapy is entering the mainstream for the treatment of CD19⁺ cancers. As is does we learn more about resistance to therapy and the role, risks and management of toxicity. In solid tumour CAR therapy research the route to the clinic is less smooth with a wealth of challenges facing translating this, potentially hugely valuable, therapeutic option for patients. As we strive to understand our successes, and navigate the challenges, having a clear understanding of how adoptively transferred CAR-T-cells behave in vivo and in human trials is invaluable. Harnessing reporter gene imaging to enable detection and tracking of small numbers of CAR-T-cells after adoptive transfer is one way by which we can accomplish this. The compatibility of certain reporter gene systems with tracers available routinely in the clinic makes this approach highly useful for future appraisal of CAR-T-cell success in humans.

Original language	English
Pages (from-to)	386-390
Number of pages	5
Journal	Biochemical Society Transactions
Volume	44
Issue number	2
DOIs	https://doi.org/10.1042/BST20150257
Publication status	Published - 15 Apr 2016

Keywords

CAR-T-cells
Dynamic imaging
PET-CT
Reporter genes
SPECT-CT

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1042/BST20150257

Cite this

@article{8478fe68728440b3b11dd09487842f55,

title = "Dynamic imaging for CAR-T-cell therapy",

abstract = "Chimaeric antigen receptor (CAR) therapy is entering the mainstream for the treatment of CD19+ cancers. As is does we learn more about resistance to therapy and the role, risks and management of toxicity. In solid tumour CAR therapy research the route to the clinic is less smooth with a wealth of challenges facing translating this, potentially hugely valuable, therapeutic option for patients. As we strive to understand our successes, and navigate the challenges, having a clear understanding of how adoptively transferred CAR-T-cells behave in vivo and in human trials is invaluable. Harnessing reporter gene imaging to enable detection and tracking of small numbers of CAR-T-cells after adoptive transfer is one way by which we can accomplish this. The compatibility of certain reporter gene systems with tracers available routinely in the clinic makes this approach highly useful for future appraisal of CAR-T-cell success in humans.",

keywords = "CAR-T-cells, Dynamic imaging, PET-CT, Reporter genes, SPECT-CT",

author = "Nia Emami-Shahri and Sophie Papa",

year = "2016",

month = apr,

day = "15",

doi = "10.1042/BST20150257",

language = "English",

volume = "44",

pages = "386--390",

journal = "Biochemical Society Transactions",

issn = "0300-5127",

publisher = "Portland Press Ltd.",

number = "2",

}

TY - JOUR

T1 - Dynamic imaging for CAR-T-cell therapy

AU - Emami-Shahri, Nia

AU - Papa, Sophie

PY - 2016/4/15

Y1 - 2016/4/15

N2 - Chimaeric antigen receptor (CAR) therapy is entering the mainstream for the treatment of CD19+ cancers. As is does we learn more about resistance to therapy and the role, risks and management of toxicity. In solid tumour CAR therapy research the route to the clinic is less smooth with a wealth of challenges facing translating this, potentially hugely valuable, therapeutic option for patients. As we strive to understand our successes, and navigate the challenges, having a clear understanding of how adoptively transferred CAR-T-cells behave in vivo and in human trials is invaluable. Harnessing reporter gene imaging to enable detection and tracking of small numbers of CAR-T-cells after adoptive transfer is one way by which we can accomplish this. The compatibility of certain reporter gene systems with tracers available routinely in the clinic makes this approach highly useful for future appraisal of CAR-T-cell success in humans.

AB - Chimaeric antigen receptor (CAR) therapy is entering the mainstream for the treatment of CD19+ cancers. As is does we learn more about resistance to therapy and the role, risks and management of toxicity. In solid tumour CAR therapy research the route to the clinic is less smooth with a wealth of challenges facing translating this, potentially hugely valuable, therapeutic option for patients. As we strive to understand our successes, and navigate the challenges, having a clear understanding of how adoptively transferred CAR-T-cells behave in vivo and in human trials is invaluable. Harnessing reporter gene imaging to enable detection and tracking of small numbers of CAR-T-cells after adoptive transfer is one way by which we can accomplish this. The compatibility of certain reporter gene systems with tracers available routinely in the clinic makes this approach highly useful for future appraisal of CAR-T-cell success in humans.

KW - CAR-T-cells

KW - Dynamic imaging

KW - PET-CT

KW - Reporter genes

KW - SPECT-CT

UR - http://www.scopus.com/inward/record.url?scp=85009837067&partnerID=8YFLogxK

U2 - 10.1042/BST20150257

DO - 10.1042/BST20150257

M3 - Article

AN - SCOPUS:85009837067

SN - 0300-5127

VL - 44

SP - 386

EP - 390

JO - Biochemical Society Transactions

JF - Biochemical Society Transactions

IS - 2

ER -

Dynamic imaging for CAR-T-cell therapy

Abstract

Keywords

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this