@inbook{312c726481ad4172b335b9cb64b0902e,
title = "Dynamic regulation of human epidermal differentiation by adhesive and mechanical forces",
abstract = "The interfollicular epidermis is the multilayered epithelium that forms the outer layer of the skin. It is maintained by stem cells that are attached to a basement membrane, which lies on top of the underlying connective tissue, the dermis. Cells undergo terminal differentiation as they detach from the basement membrane and move toward the outer epidermal surface. Over time, many of the molecular regulators of this process have been identified. It is now is clear that these pathways also receive critical input from the physical properties of the tissue. In this review, we describe how changes in these factors regulate differentiation and how new insights from single cell RNA sequencing could provide validation or challenge to the existing experimental models.",
keywords = "Differentiation, Epidermal stem cells, Epidermis, Keratinocytes, Mechanobiology",
author = "Sebastiaan Zijl and Vasiliki Salameti and Blaise Louis and Negri, {Victor A.} and Watt, {Fiona M.}",
note = "Funding Information: The authors gratefully acknowledge the financial support from the UK Regenerative Medicine Platform (UKRMP; MR/R015635/1), the Centre for Cellular Signal Patterns (CellPAT) initiative (Danish National Research Foundation), Medical Research Council (MR/PO18823/1), Biotechnology and Biological Sciences Research Council (BB/S506898/1) and Wellcome Trust (206439/Z/17/Z). Publisher Copyright: {\textcopyright} 2022 Elsevier Inc.",
year = "2022",
month = jan,
doi = "10.1016/bs.ctdb.2022.03.004",
language = "English",
isbn = "9780128201558",
series = "Current Topics in Developmental Biology",
publisher = "ACADEMIC PRESS INC",
pages = "129--148",
editor = "Thomas Kornberg",
booktitle = "Cell-Cell Signaling in Development",
address = "United States",
}