Dynamic regulation of human epidermal differentiation by adhesive and mechanical forces

Sebastiaan Zijl, Vasiliki Salameti, Blaise Louis, Victor A. Negri, Fiona M. Watt*

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

1 Citation (Scopus)


The interfollicular epidermis is the multilayered epithelium that forms the outer layer of the skin. It is maintained by stem cells that are attached to a basement membrane, which lies on top of the underlying connective tissue, the dermis. Cells undergo terminal differentiation as they detach from the basement membrane and move toward the outer epidermal surface. Over time, many of the molecular regulators of this process have been identified. It is now is clear that these pathways also receive critical input from the physical properties of the tissue. In this review, we describe how changes in these factors regulate differentiation and how new insights from single cell RNA sequencing could provide validation or challenge to the existing experimental models.

Original languageEnglish
Title of host publicationCell-Cell Signaling in Development
EditorsThomas Kornberg
Number of pages20
ISBN (Print)9780128201558
Publication statusPublished - Jan 2022

Publication series

NameCurrent Topics in Developmental Biology
ISSN (Print)0070-2153


  • Differentiation
  • Epidermal stem cells
  • Epidermis
  • Keratinocytes
  • Mechanobiology


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