Dysbindin modulates brain function during visual processing in children

A. Mechelli, E. Viding, A. Kumar, W. Pettersson-Yeo, P. Fusar-Poli, Stefania Tognin, M. C. O'Donovan, P. McGuire

Research output: Contribution to journalArticlepeer-review

13 Citations (Scopus)


Schizophrenia is a neurodevelopmental disorder, and risk genes are thought to act through disruption of brain development. Several genetic studies have identified dystrobrevin binding protein 1 (DTNBP1, also known as dysbindin) as a potential susceptibility gene for schizophrenia, but its impact on brain function is poorly understood. it has been proposed that DTNBP1 may be associated with differences in visual processing. To test this, we examined the impact on visual processing in 61 healthy children aged 10-12 years of a genetic variant in DTNBP1 (rs2619538) that was common to all schizophrenia associated haplotypes in an earlier UK-Irish Study. We tested the hypothesis that carriers of the risk allele would show altered occipital cortical function relative to noncarriers. Functional Magnetic Resonance Imaging (fMRI) was used to measure brain responses during a visual matching task. The data were analysed using statistical parametric mapping and statistical inferences were made at p
Original languageEnglish
Pages (from-to)817 - 822
Number of pages6
Issue number1
Publication statusPublished - 1 Jan 2010


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