Dysbindin modulates brain function during visual processing in children

TY - JOUR

T1 - Dysbindin modulates brain function during visual processing in children

AU - Mechelli, A.

AU - Viding, E.

AU - Kumar, A.

AU - Pettersson-Yeo, W.

AU - Fusar-Poli, P.

AU - Tognin, Stefania

AU - O'Donovan, M. C.

AU - McGuire, P.

PY - 2010/1/1

Y1 - 2010/1/1

N2 - Schizophrenia is a neurodevelopmental disorder, and risk genes are thought to act through disruption of brain development. Several genetic studies have identified dystrobrevin binding protein 1 (DTNBP1, also known as dysbindin) as a potential susceptibility gene for schizophrenia, but its impact on brain function is poorly understood. it has been proposed that DTNBP1 may be associated with differences in visual processing. To test this, we examined the impact on visual processing in 61 healthy children aged 10-12 years of a genetic variant in DTNBP1 (rs2619538) that was common to all schizophrenia associated haplotypes in an earlier UK-Irish Study. We tested the hypothesis that carriers of the risk allele would show altered occipital cortical function relative to noncarriers. Functional Magnetic Resonance Imaging (fMRI) was used to measure brain responses during a visual matching task. The data were analysed using statistical parametric mapping and statistical inferences were made at p

AB - Schizophrenia is a neurodevelopmental disorder, and risk genes are thought to act through disruption of brain development. Several genetic studies have identified dystrobrevin binding protein 1 (DTNBP1, also known as dysbindin) as a potential susceptibility gene for schizophrenia, but its impact on brain function is poorly understood. it has been proposed that DTNBP1 may be associated with differences in visual processing. To test this, we examined the impact on visual processing in 61 healthy children aged 10-12 years of a genetic variant in DTNBP1 (rs2619538) that was common to all schizophrenia associated haplotypes in an earlier UK-Irish Study. We tested the hypothesis that carriers of the risk allele would show altered occipital cortical function relative to noncarriers. Functional Magnetic Resonance Imaging (fMRI) was used to measure brain responses during a visual matching task. The data were analysed using statistical parametric mapping and statistical inferences were made at p

U2 - 10.1016/j.neuroimage.2009.07.030

DO - 10.1016/j.neuroimage.2009.07.030

M3 - Article

SN - 1095-9572

VL - 49

SP - 817

EP - 822

JO - NeuroImage

JF - NeuroImage

IS - 1

ER -