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Dysfunction of Persisting β Cells Is a Key Feature of Early Type 2 Diabetes Pathogenesis

Research output: Contribution to journalArticle

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Dysfunction of Persisting β Cells Is a Key Feature of Early Type 2 Diabetes Pathogenesis. / Cohrs, Christian M.; Panzer, Julia K.; Drotar, Denise M.; Enos, Stephen J.; Kipke, Nicole; Chen, Chunguang; Bozsak, Robert; Schöniger, Eyke; Ehehalt, Florian; Distler, Marius; Brennand, Ana; Bornstein, Stefan R.; Weitz, Jürgen; Solimena, Michele; Speier, Stephan.

In: Cell Reports, Vol. 31, No. 1, 107469, 07.04.2020.

Research output: Contribution to journalArticle

Harvard

Cohrs, CM, Panzer, JK, Drotar, DM, Enos, SJ, Kipke, N, Chen, C, Bozsak, R, Schöniger, E, Ehehalt, F, Distler, M, Brennand, A, Bornstein, SR, Weitz, J, Solimena, M & Speier, S 2020, 'Dysfunction of Persisting β Cells Is a Key Feature of Early Type 2 Diabetes Pathogenesis', Cell Reports, vol. 31, no. 1, 107469. https://doi.org/10.1016/j.celrep.2020.03.033

APA

Cohrs, C. M., Panzer, J. K., Drotar, D. M., Enos, S. J., Kipke, N., Chen, C., ... Speier, S. (2020). Dysfunction of Persisting β Cells Is a Key Feature of Early Type 2 Diabetes Pathogenesis. Cell Reports, 31(1), [107469]. https://doi.org/10.1016/j.celrep.2020.03.033

Vancouver

Cohrs CM, Panzer JK, Drotar DM, Enos SJ, Kipke N, Chen C et al. Dysfunction of Persisting β Cells Is a Key Feature of Early Type 2 Diabetes Pathogenesis. Cell Reports. 2020 Apr 7;31(1). 107469. https://doi.org/10.1016/j.celrep.2020.03.033

Author

Cohrs, Christian M. ; Panzer, Julia K. ; Drotar, Denise M. ; Enos, Stephen J. ; Kipke, Nicole ; Chen, Chunguang ; Bozsak, Robert ; Schöniger, Eyke ; Ehehalt, Florian ; Distler, Marius ; Brennand, Ana ; Bornstein, Stefan R. ; Weitz, Jürgen ; Solimena, Michele ; Speier, Stephan. / Dysfunction of Persisting β Cells Is a Key Feature of Early Type 2 Diabetes Pathogenesis. In: Cell Reports. 2020 ; Vol. 31, No. 1.

Bibtex Download

@article{0980754032024d49950974ff340272c7,
title = "Dysfunction of Persisting β Cells Is a Key Feature of Early Type 2 Diabetes Pathogenesis",
abstract = "Type 2 diabetes is characterized by peripheral insulin resistance and insufficient insulin release from pancreatic islet β cells. However, the role and sequence of β cell dysfunction and mass loss for reduced insulin levels in type 2 diabetes pathogenesis are unclear. Here, we exploit freshly explanted pancreas specimens from metabolically phenotyped surgical patients using an in situ tissue slice technology. This approach allows assessment of β cell volume and function within pancreas samples of metabolically stratified individuals. We show that, in tissue of pre-diabetic, impaired glucose-tolerant subjects, β cell volume is unchanged, but function significantly deteriorates, exhibiting increased basal release and loss of first-phase insulin secretion. In individuals with type 2 diabetes, function within the sustained β cell volume further declines. These results indicate that dysfunction of persisting β cells is a key factor in the early development and progression of type 2 diabetes, representing a major target for diabetes prevention and therapy.",
keywords = "beta cell function, beta cell mass, human pancreas, insulin secretion, Type 2 diabetes",
author = "Cohrs, {Christian M.} and Panzer, {Julia K.} and Drotar, {Denise M.} and Enos, {Stephen J.} and Nicole Kipke and Chunguang Chen and Robert Bozsak and Eyke Sch{\"o}niger and Florian Ehehalt and Marius Distler and Ana Brennand and Bornstein, {Stefan R.} and J{\"u}rgen Weitz and Michele Solimena and Stephan Speier",
year = "2020",
month = "4",
day = "7",
doi = "10.1016/j.celrep.2020.03.033",
language = "English",
volume = "31",
journal = "Cell Reports",
issn = "2211-1247",
publisher = "Elsevier BV",
number = "1",

}

RIS (suitable for import to EndNote) Download

TY - JOUR

T1 - Dysfunction of Persisting β Cells Is a Key Feature of Early Type 2 Diabetes Pathogenesis

AU - Cohrs, Christian M.

AU - Panzer, Julia K.

AU - Drotar, Denise M.

AU - Enos, Stephen J.

AU - Kipke, Nicole

AU - Chen, Chunguang

AU - Bozsak, Robert

AU - Schöniger, Eyke

AU - Ehehalt, Florian

AU - Distler, Marius

AU - Brennand, Ana

AU - Bornstein, Stefan R.

AU - Weitz, Jürgen

AU - Solimena, Michele

AU - Speier, Stephan

PY - 2020/4/7

Y1 - 2020/4/7

N2 - Type 2 diabetes is characterized by peripheral insulin resistance and insufficient insulin release from pancreatic islet β cells. However, the role and sequence of β cell dysfunction and mass loss for reduced insulin levels in type 2 diabetes pathogenesis are unclear. Here, we exploit freshly explanted pancreas specimens from metabolically phenotyped surgical patients using an in situ tissue slice technology. This approach allows assessment of β cell volume and function within pancreas samples of metabolically stratified individuals. We show that, in tissue of pre-diabetic, impaired glucose-tolerant subjects, β cell volume is unchanged, but function significantly deteriorates, exhibiting increased basal release and loss of first-phase insulin secretion. In individuals with type 2 diabetes, function within the sustained β cell volume further declines. These results indicate that dysfunction of persisting β cells is a key factor in the early development and progression of type 2 diabetes, representing a major target for diabetes prevention and therapy.

AB - Type 2 diabetes is characterized by peripheral insulin resistance and insufficient insulin release from pancreatic islet β cells. However, the role and sequence of β cell dysfunction and mass loss for reduced insulin levels in type 2 diabetes pathogenesis are unclear. Here, we exploit freshly explanted pancreas specimens from metabolically phenotyped surgical patients using an in situ tissue slice technology. This approach allows assessment of β cell volume and function within pancreas samples of metabolically stratified individuals. We show that, in tissue of pre-diabetic, impaired glucose-tolerant subjects, β cell volume is unchanged, but function significantly deteriorates, exhibiting increased basal release and loss of first-phase insulin secretion. In individuals with type 2 diabetes, function within the sustained β cell volume further declines. These results indicate that dysfunction of persisting β cells is a key factor in the early development and progression of type 2 diabetes, representing a major target for diabetes prevention and therapy.

KW - beta cell function

KW - beta cell mass

KW - human pancreas

KW - insulin secretion

KW - Type 2 diabetes

UR - http://www.scopus.com/inward/record.url?scp=85082749972&partnerID=8YFLogxK

U2 - 10.1016/j.celrep.2020.03.033

DO - 10.1016/j.celrep.2020.03.033

M3 - Article

C2 - 32268101

AN - SCOPUS:85082749972

VL - 31

JO - Cell Reports

JF - Cell Reports

SN - 2211-1247

IS - 1

M1 - 107469

ER -

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