Early antiretroviral therapy reduces HIV DNA following perinatal HIV infection

Caroline Foster*, Matthew Pace, Steve Kaye, Emily Hopkins, Mathew Jones, Nicola Robinson, Christine Mant, John Cason, Sarah Fidler, John Frater

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

29 Citations (Scopus)

Abstract

The impact of antiretroviral therapy (ART) on the size of the HIV reservoir has implications for virological remission in adults, but is not well characterized in perinatally acquired infection. In a prospective observational study of 20 children with perinatally acquired infection and sustained viral suppression on ART for more than 5 years, proviral DNA was significantly higher in deferred (>4 years) versus early (first year of life) ART recipients (P = 0.0062), and correlated with age of initiation (P = 0.13; r = 0.57). No difference was seen in cell-associated viral RNA (P = 0.36). Identifying paediatric populations with smaller reservoirs may inform strategies with potential to induce ART-free remission.

Original languageEnglish
Pages (from-to)1847-1851
Number of pages5
JournalAIDS (London, England)
Volume31
Issue number13
Early online date12 Jun 2017
DOIs
Publication statusPublished - 24 Aug 2017

Keywords

  • early antiretroviral therapy
  • HIV reservoir
  • perinatally infected children

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