Early antiretroviral therapy reduces HIV DNA following perinatal HIV infection

Caroline Foster; Matthew Pace; Steve Kaye; Emily Hopkins; Mathew Jones; Nicola Robinson; Christine Mant; John Cason; Sarah Fidler; John Frater

doi:10.1097/QAD.0000000000001565

Early antiretroviral therapy reduces HIV DNA following perinatal HIV infection

Caroline Foster^*, Matthew Pace, Steve Kaye, Emily Hopkins, Mathew Jones, Nicola Robinson, Christine Mant, John Cason, Sarah Fidler, John Frater

^*Corresponding author for this work

Infectious Diseases

Research output: Contribution to journal › Article › peer-review

30 Citations (Scopus)

Abstract

The impact of antiretroviral therapy (ART) on the size of the HIV reservoir has implications for virological remission in adults, but is not well characterized in perinatally acquired infection. In a prospective observational study of 20 children with perinatally acquired infection and sustained viral suppression on ART for more than 5 years, proviral DNA was significantly higher in deferred (>4 years) versus early (first year of life) ART recipients (P = 0.0062), and correlated with age of initiation (P = 0.13; r = 0.57). No difference was seen in cell-associated viral RNA (P = 0.36). Identifying paediatric populations with smaller reservoirs may inform strategies with potential to induce ART-free remission.

Original language	English
Pages (from-to)	1847-1851
Number of pages	5
Journal	AIDS (London, England)
Volume	31
Issue number	13
Early online date	12 Jun 2017
DOIs	https://doi.org/10.1097/QAD.0000000000001565
Publication status	Published - 24 Aug 2017

Keywords

early antiretroviral therapy
HIV reservoir
perinatally infected children

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1097/QAD.0000000000001565

Cite this

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abstract = "The impact of antiretroviral therapy (ART) on the size of the HIV reservoir has implications for virological remission in adults, but is not well characterized in perinatally acquired infection. In a prospective observational study of 20 children with perinatally acquired infection and sustained viral suppression on ART for more than 5 years, proviral DNA was significantly higher in deferred (>4 years) versus early (first year of life) ART recipients (P = 0.0062), and correlated with age of initiation (P = 0.13; r = 0.57). No difference was seen in cell-associated viral RNA (P = 0.36). Identifying paediatric populations with smaller reservoirs may inform strategies with potential to induce ART-free remission.",

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T1 - Early antiretroviral therapy reduces HIV DNA following perinatal HIV infection

AU - Foster, Caroline

AU - Pace, Matthew

AU - Kaye, Steve

AU - Hopkins, Emily

AU - Jones, Mathew

AU - Robinson, Nicola

AU - Mant, Christine

AU - Cason, John

AU - Fidler, Sarah

AU - Frater, John

PY - 2017/8/24

Y1 - 2017/8/24

N2 - The impact of antiretroviral therapy (ART) on the size of the HIV reservoir has implications for virological remission in adults, but is not well characterized in perinatally acquired infection. In a prospective observational study of 20 children with perinatally acquired infection and sustained viral suppression on ART for more than 5 years, proviral DNA was significantly higher in deferred (>4 years) versus early (first year of life) ART recipients (P = 0.0062), and correlated with age of initiation (P = 0.13; r = 0.57). No difference was seen in cell-associated viral RNA (P = 0.36). Identifying paediatric populations with smaller reservoirs may inform strategies with potential to induce ART-free remission.

AB - The impact of antiretroviral therapy (ART) on the size of the HIV reservoir has implications for virological remission in adults, but is not well characterized in perinatally acquired infection. In a prospective observational study of 20 children with perinatally acquired infection and sustained viral suppression on ART for more than 5 years, proviral DNA was significantly higher in deferred (>4 years) versus early (first year of life) ART recipients (P = 0.0062), and correlated with age of initiation (P = 0.13; r = 0.57). No difference was seen in cell-associated viral RNA (P = 0.36). Identifying paediatric populations with smaller reservoirs may inform strategies with potential to induce ART-free remission.

KW - early antiretroviral therapy

KW - HIV reservoir

KW - perinatally infected children

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Early antiretroviral therapy reduces HIV DNA following perinatal HIV infection

Abstract

Keywords

UN SDGs

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