Research output: Contribution to journal › Article › peer-review
Caroline Foster, Matthew Pace, Steve Kaye, Emily Hopkins, Mathew Jones, Nicola Robinson, Christine Mant, John Cason, Sarah Fidler, John Frater
| Original language | English |
|---|---|
| Pages (from-to) | 1847-1851 |
| Number of pages | 5 |
| Journal | AIDS (London, England) |
| Volume | 31 |
| Issue number | 13 |
| Early online date | 12 Jun 2017 |
| DOIs | |
| Accepted/In press | 4 Jun 2017 |
| E-pub ahead of print | 12 Jun 2017 |
| Published | 24 Aug 2017 |
| Additional links |
The impact of antiretroviral therapy (ART) on the size of the HIV reservoir has implications for virological remission in adults, but is not well characterized in perinatally acquired infection. In a prospective observational study of 20 children with perinatally acquired infection and sustained viral suppression on ART for more than 5 years, proviral DNA was significantly higher in deferred (>4 years) versus early (first year of life) ART recipients (P = 0.0062), and correlated with age of initiation (P = 0.13; r = 0.57). No difference was seen in cell-associated viral RNA (P = 0.36). Identifying paediatric populations with smaller reservoirs may inform strategies with potential to induce ART-free remission.
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