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Early antiretroviral therapy reduces HIV DNA following perinatal HIV infection

Research output: Contribution to journalArticlepeer-review

Caroline Foster, Matthew Pace, Steve Kaye, Emily Hopkins, Mathew Jones, Nicola Robinson, Christine Mant, John Cason, Sarah Fidler, John Frater

Original languageEnglish
Pages (from-to)1847-1851
Number of pages5
JournalAIDS (London, England)
Issue number13
Early online date12 Jun 2017
Accepted/In press4 Jun 2017
E-pub ahead of print12 Jun 2017
Published24 Aug 2017

King's Authors


The impact of antiretroviral therapy (ART) on the size of the HIV reservoir has implications for virological remission in adults, but is not well characterized in perinatally acquired infection. In a prospective observational study of 20 children with perinatally acquired infection and sustained viral suppression on ART for more than 5 years, proviral DNA was significantly higher in deferred (>4 years) versus early (first year of life) ART recipients (P = 0.0062), and correlated with age of initiation (P = 0.13; r = 0.57). No difference was seen in cell-associated viral RNA (P = 0.36). Identifying paediatric populations with smaller reservoirs may inform strategies with potential to induce ART-free remission.

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