Early cytomegalovirus infections following allogeneic stem cell transplantation: a comparison between non-malignant and malignant haematological disorders

Md Serajul Islam; Parameswaran Anoop; Phil Rice; Reuben Benjamin; Preeti Datta-Nemdharry; Edward C. Gordon-Smith; Judith Marsh

doi:10.1179/102453310X12583347009612

Early cytomegalovirus infections following allogeneic stem cell transplantation: a comparison between non-malignant and malignant haematological disorders

Md Serajul Islam^*, Parameswaran Anoop, Phil Rice, Reuben Benjamin, Preeti Datta-Nemdharry, Edward C. Gordon-Smith, Judith Marsh

^*Corresponding author for this work

St George's University Hospitals NHS Foundation Trust

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

The haematological indications for allogeneic stem cell transplantation can be broadly divided into non-malignant and malignant disorders. We compared the incidence and risk factors for post-transplant cytomegalovirus (CMV) infections between these two biologically diverse subgroups of haematological conditions. Out of 105 allogeneic transplants, 64 and 41 were for underlying non-malignant and malignant indications respectively. CMV infections were significantly more frequent (P=0.016) in the malignant subgroup. Pre-transplant recipient CMV seropositivity in both subgroups (negative versus positive; non-malignant, P=0.023; malignant, p= 3 courses of previous cytotoxic therapy (P=0.023) in the malignant subgroup were found to be associated with an increased risk of CMV infections. On multivariate analysis, donor seropositivity in the non-malignant patients (negative versus positive, P=0.022; odds ratio: 0.18) and recipient seropositivity in patients with malignancies (negative versus positive; P=0.001, odds ratio: 0.01) were identified to be significant factors for risk of CMV infection.

Original language	English
Pages (from-to)	4-10
Number of pages	7
Journal	HEMATOLOGY
Volume	15
Issue number	1
DOIs	https://doi.org/10.1179/102453310X12583347009612
Publication status	Published - Feb 2010

Keywords

Cytomegalovirus
risk
transplantation
non-malignant
malignant
BONE-MARROW-TRANSPLANTATION
VERSUS-HOST-DISEASE
ACQUIRED APLASTIC-ANEMIA
ANTI-THYMOCYTE GLOBULIN
PERIPHERAL-BLOOD
IMMUNOSUPPRESSIVE THERAPY
UNRELATED DONORS
RISK-FACTORS
CORD BLOOD
REACTIVATION

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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title = "Early cytomegalovirus infections following allogeneic stem cell transplantation: a comparison between non-malignant and malignant haematological disorders",

abstract = "The haematological indications for allogeneic stem cell transplantation can be broadly divided into non-malignant and malignant disorders. We compared the incidence and risk factors for post-transplant cytomegalovirus (CMV) infections between these two biologically diverse subgroups of haematological conditions. Out of 105 allogeneic transplants, 64 and 41 were for underlying non-malignant and malignant indications respectively. CMV infections were significantly more frequent (P=0.016) in the malignant subgroup. Pre-transplant recipient CMV seropositivity in both subgroups (negative versus positive; non-malignant, P=0.023; malignant, p= 3 courses of previous cytotoxic therapy (P=0.023) in the malignant subgroup were found to be associated with an increased risk of CMV infections. On multivariate analysis, donor seropositivity in the non-malignant patients (negative versus positive, P=0.022; odds ratio: 0.18) and recipient seropositivity in patients with malignancies (negative versus positive; P=0.001, odds ratio: 0.01) were identified to be significant factors for risk of CMV infection.",

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author = "Islam, {Md Serajul} and Parameswaran Anoop and Phil Rice and Reuben Benjamin and Preeti Datta-Nemdharry and Gordon-Smith, {Edward C.} and Judith Marsh",

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T2 - a comparison between non-malignant and malignant haematological disorders

AU - Islam, Md Serajul

AU - Anoop, Parameswaran

AU - Rice, Phil

AU - Benjamin, Reuben

AU - Datta-Nemdharry, Preeti

AU - Gordon-Smith, Edward C.

AU - Marsh, Judith

PY - 2010/2

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N2 - The haematological indications for allogeneic stem cell transplantation can be broadly divided into non-malignant and malignant disorders. We compared the incidence and risk factors for post-transplant cytomegalovirus (CMV) infections between these two biologically diverse subgroups of haematological conditions. Out of 105 allogeneic transplants, 64 and 41 were for underlying non-malignant and malignant indications respectively. CMV infections were significantly more frequent (P=0.016) in the malignant subgroup. Pre-transplant recipient CMV seropositivity in both subgroups (negative versus positive; non-malignant, P=0.023; malignant, p= 3 courses of previous cytotoxic therapy (P=0.023) in the malignant subgroup were found to be associated with an increased risk of CMV infections. On multivariate analysis, donor seropositivity in the non-malignant patients (negative versus positive, P=0.022; odds ratio: 0.18) and recipient seropositivity in patients with malignancies (negative versus positive; P=0.001, odds ratio: 0.01) were identified to be significant factors for risk of CMV infection.

AB - The haematological indications for allogeneic stem cell transplantation can be broadly divided into non-malignant and malignant disorders. We compared the incidence and risk factors for post-transplant cytomegalovirus (CMV) infections between these two biologically diverse subgroups of haematological conditions. Out of 105 allogeneic transplants, 64 and 41 were for underlying non-malignant and malignant indications respectively. CMV infections were significantly more frequent (P=0.016) in the malignant subgroup. Pre-transplant recipient CMV seropositivity in both subgroups (negative versus positive; non-malignant, P=0.023; malignant, p= 3 courses of previous cytotoxic therapy (P=0.023) in the malignant subgroup were found to be associated with an increased risk of CMV infections. On multivariate analysis, donor seropositivity in the non-malignant patients (negative versus positive, P=0.022; odds ratio: 0.18) and recipient seropositivity in patients with malignancies (negative versus positive; P=0.001, odds ratio: 0.01) were identified to be significant factors for risk of CMV infection.

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KW - malignant

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KW - ACQUIRED APLASTIC-ANEMIA

KW - ANTI-THYMOCYTE GLOBULIN

KW - PERIPHERAL-BLOOD

KW - IMMUNOSUPPRESSIVE THERAPY

KW - UNRELATED DONORS

KW - RISK-FACTORS

KW - CORD BLOOD

KW - REACTIVATION

U2 - 10.1179/102453310X12583347009612

DO - 10.1179/102453310X12583347009612

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JF - HEMATOLOGY

IS - 1

ER -

Early cytomegalovirus infections following allogeneic stem cell transplantation: a comparison between non-malignant and malignant haematological disorders

Abstract

Keywords

UN SDGs

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