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Early developmental pathways to childhood symptoms of attention-deficit hyperactivity disorder, anxiety and autism spectrum disorder

Research output: Contribution to journalArticle

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Early developmental pathways to childhood symptoms of attention-deficit hyperactivity disorder, anxiety and autism spectrum disorder. / Shephard, Elizabeth; Bedford, Rachael; Milosavljevic, Bosiljka; Gliga, Teodora; Jones, Emily JH; Pickles, Andrew; Johnson, Mark; Charman, Tony.

In: Journal of Child Psychology and Psychiatry, 02.07.2018.

Research output: Contribution to journalArticle

Harvard

Shephard, E, Bedford, R, Milosavljevic, B, Gliga, T, Jones, EJH, Pickles, A, Johnson, M & Charman, T 2018, 'Early developmental pathways to childhood symptoms of attention-deficit hyperactivity disorder, anxiety and autism spectrum disorder', Journal of Child Psychology and Psychiatry. https://doi.org/10.1111/jcpp.12947

APA

Shephard, E., Bedford, R., Milosavljevic, B., Gliga, T., Jones, E. JH., Pickles, A., ... Charman, T. (2018). Early developmental pathways to childhood symptoms of attention-deficit hyperactivity disorder, anxiety and autism spectrum disorder. Journal of Child Psychology and Psychiatry. https://doi.org/10.1111/jcpp.12947

Vancouver

Shephard E, Bedford R, Milosavljevic B, Gliga T, Jones EJH, Pickles A et al. Early developmental pathways to childhood symptoms of attention-deficit hyperactivity disorder, anxiety and autism spectrum disorder. Journal of Child Psychology and Psychiatry. 2018 Jul 2. https://doi.org/10.1111/jcpp.12947

Author

Shephard, Elizabeth ; Bedford, Rachael ; Milosavljevic, Bosiljka ; Gliga, Teodora ; Jones, Emily JH ; Pickles, Andrew ; Johnson, Mark ; Charman, Tony. / Early developmental pathways to childhood symptoms of attention-deficit hyperactivity disorder, anxiety and autism spectrum disorder. In: Journal of Child Psychology and Psychiatry. 2018.

Bibtex Download

@article{06f759cb877e42619b7c378bf8b36df6,
title = "Early developmental pathways to childhood symptoms of attention-deficit hyperactivity disorder, anxiety and autism spectrum disorder",
abstract = "Background: Children with autism spectrum disorder (ASD) often have co-occurring symptoms of attention-deficit/hyperactivity disorder (ADHD) and/or anxiety. It is unclear whether these disorders arise from shared or distinctdevelopmental pathways. We explored this question by testing the specificity of early-life (infant and toddler) predictors of mid-childhood ADHD and anxiety symptoms compared to ASD symptoms. Methods: Infants (n = 104) at high and low familial risk for ASD took part in research assessments at 7, 14, 24 and 38 months, and 7 years of age. Symptoms of ASD, ADHD and anxiety were measured by parent report at age 7. Activity levels and inhibitory control, also measured by parent report, in infancy and toddlerhood were used as early-life predictors of ADHD symptoms. Fearfulness and shyness measured in infancy and toddlerhood were used as early-life predictors of anxiety symptoms. Correlations and path analysis models tested associations between early-life predictors and midchildhood ADHD and anxiety symptoms compared to mid-childhood ASD symptoms, and the influence of controlling for ASD symptoms on those associations. Results: Increased activity levels and poor inhibitory control werecorrelated with ADHD symptoms and not ASD or anxiety; these associations were unchanged in path models controlling for risk-group and ASD symptoms. Increased fearfulness and shyness were correlated with anxietysymptoms, but also ASD symptoms. When controlling for risk-group in path analysis, the association between shyness and anxiety became nonsignificant, and when further controlling for ASD symptoms the association betweenfearfulness and anxiety became marginal. Conclusions: The specificity of early-life predictors to ADHD symptoms suggests early developmental pathways to ADHD might be distinct from ASD. The overlap in early-life predictors ofanxiety and ASD suggests that these disorders are difficult to differentiate early in life, which could reflect the presence of common developmental pathways or convergence in early behavioural manifestations of these disorders.",
keywords = "Autism spectrum disorder, attention-deficit/hyperactivity disorder, anxiety, comorbidity, early developmental pathways",
author = "Elizabeth Shephard and Rachael Bedford and Bosiljka Milosavljevic and Teodora Gliga and Jones, {Emily JH} and Andrew Pickles and Mark Johnson and Tony Charman",
year = "2018",
month = "7",
day = "2",
doi = "10.1111/jcpp.12947",
language = "English",
journal = "Journal of Child Psychology and Psychiatry",
issn = "0021-9630",

}

RIS (suitable for import to EndNote) Download

TY - JOUR

T1 - Early developmental pathways to childhood symptoms of attention-deficit hyperactivity disorder, anxiety and autism spectrum disorder

AU - Shephard, Elizabeth

AU - Bedford, Rachael

AU - Milosavljevic, Bosiljka

AU - Gliga, Teodora

AU - Jones, Emily JH

AU - Pickles, Andrew

AU - Johnson, Mark

AU - Charman, Tony

PY - 2018/7/2

Y1 - 2018/7/2

N2 - Background: Children with autism spectrum disorder (ASD) often have co-occurring symptoms of attention-deficit/hyperactivity disorder (ADHD) and/or anxiety. It is unclear whether these disorders arise from shared or distinctdevelopmental pathways. We explored this question by testing the specificity of early-life (infant and toddler) predictors of mid-childhood ADHD and anxiety symptoms compared to ASD symptoms. Methods: Infants (n = 104) at high and low familial risk for ASD took part in research assessments at 7, 14, 24 and 38 months, and 7 years of age. Symptoms of ASD, ADHD and anxiety were measured by parent report at age 7. Activity levels and inhibitory control, also measured by parent report, in infancy and toddlerhood were used as early-life predictors of ADHD symptoms. Fearfulness and shyness measured in infancy and toddlerhood were used as early-life predictors of anxiety symptoms. Correlations and path analysis models tested associations between early-life predictors and midchildhood ADHD and anxiety symptoms compared to mid-childhood ASD symptoms, and the influence of controlling for ASD symptoms on those associations. Results: Increased activity levels and poor inhibitory control werecorrelated with ADHD symptoms and not ASD or anxiety; these associations were unchanged in path models controlling for risk-group and ASD symptoms. Increased fearfulness and shyness were correlated with anxietysymptoms, but also ASD symptoms. When controlling for risk-group in path analysis, the association between shyness and anxiety became nonsignificant, and when further controlling for ASD symptoms the association betweenfearfulness and anxiety became marginal. Conclusions: The specificity of early-life predictors to ADHD symptoms suggests early developmental pathways to ADHD might be distinct from ASD. The overlap in early-life predictors ofanxiety and ASD suggests that these disorders are difficult to differentiate early in life, which could reflect the presence of common developmental pathways or convergence in early behavioural manifestations of these disorders.

AB - Background: Children with autism spectrum disorder (ASD) often have co-occurring symptoms of attention-deficit/hyperactivity disorder (ADHD) and/or anxiety. It is unclear whether these disorders arise from shared or distinctdevelopmental pathways. We explored this question by testing the specificity of early-life (infant and toddler) predictors of mid-childhood ADHD and anxiety symptoms compared to ASD symptoms. Methods: Infants (n = 104) at high and low familial risk for ASD took part in research assessments at 7, 14, 24 and 38 months, and 7 years of age. Symptoms of ASD, ADHD and anxiety were measured by parent report at age 7. Activity levels and inhibitory control, also measured by parent report, in infancy and toddlerhood were used as early-life predictors of ADHD symptoms. Fearfulness and shyness measured in infancy and toddlerhood were used as early-life predictors of anxiety symptoms. Correlations and path analysis models tested associations between early-life predictors and midchildhood ADHD and anxiety symptoms compared to mid-childhood ASD symptoms, and the influence of controlling for ASD symptoms on those associations. Results: Increased activity levels and poor inhibitory control werecorrelated with ADHD symptoms and not ASD or anxiety; these associations were unchanged in path models controlling for risk-group and ASD symptoms. Increased fearfulness and shyness were correlated with anxietysymptoms, but also ASD symptoms. When controlling for risk-group in path analysis, the association between shyness and anxiety became nonsignificant, and when further controlling for ASD symptoms the association betweenfearfulness and anxiety became marginal. Conclusions: The specificity of early-life predictors to ADHD symptoms suggests early developmental pathways to ADHD might be distinct from ASD. The overlap in early-life predictors ofanxiety and ASD suggests that these disorders are difficult to differentiate early in life, which could reflect the presence of common developmental pathways or convergence in early behavioural manifestations of these disorders.

KW - Autism spectrum disorder

KW - attention-deficit/hyperactivity disorder

KW - anxiety

KW - comorbidity

KW - early developmental pathways

U2 - 10.1111/jcpp.12947

DO - 10.1111/jcpp.12947

M3 - Article

JO - Journal of Child Psychology and Psychiatry

JF - Journal of Child Psychology and Psychiatry

SN - 0021-9630

ER -

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