Early differences in auditory processing relate to Autism Spectrum Disorder traits in infants with Neurofibromatosis Type I

the STAARS and EDEN Teams

doi:10.1186/s11689-021-09364-3

Early differences in auditory processing relate to Autism Spectrum Disorder traits in infants with Neurofibromatosis Type I

the STAARS and EDEN Teams

Research output: Contribution to journal › Article › peer-review

18 Citations (Scopus)

Abstract

Background: Sensory modulation difficulties are common in children with conditions such as Autism Spectrum Disorder (ASD) and could contribute to other social and non-social symptoms. Positing a causal role for sensory processing differences requires observing atypical sensory reactivity prior to the emergence of other symptoms, which can be achieved through prospective studies. Methods: In this longitudinal study, we examined auditory repetition suppression and change detection at 5 and 10 months in infants with and without Neurofibromatosis Type 1 (NF1), a condition associated with higher likelihood of developing ASD. Results: In typically developing infants, suppression to vowel repetition and enhanced responses to vowel/pitch change decreased with age over posterior regions, becoming more frontally specific; age-related change was diminished in the NF1 group. Whilst both groups detected changes in vowel and pitch, the NF1 group were largely slower to show a differentiated neural response. Auditory responses did not relate to later language, but were related to later ASD traits. Conclusions: These findings represent the first demonstration of atypical brain responses to sounds in infants with NF1 and suggest they may relate to the likelihood of later ASD.

Original language	English
Article number	22
Journal	Journal Of Neurodevelopmental Disorders
Volume	13
Issue number	1
DOIs	https://doi.org/10.1186/s11689-021-09364-3
Publication status	Published - Dec 2021

Keywords

Auditory processing
Autism spectrum disorder
Change detection
EEG
Habituation
Neurofibromatosis type 1

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10.1186/s11689-021-09364-3

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@article{1466e0d53176475f96e73cc7149f3513,

title = "Early differences in auditory processing relate to Autism Spectrum Disorder traits in infants with Neurofibromatosis Type I",

abstract = "Background: Sensory modulation difficulties are common in children with conditions such as Autism Spectrum Disorder (ASD) and could contribute to other social and non-social symptoms. Positing a causal role for sensory processing differences requires observing atypical sensory reactivity prior to the emergence of other symptoms, which can be achieved through prospective studies. Methods: In this longitudinal study, we examined auditory repetition suppression and change detection at 5 and 10 months in infants with and without Neurofibromatosis Type 1 (NF1), a condition associated with higher likelihood of developing ASD. Results: In typically developing infants, suppression to vowel repetition and enhanced responses to vowel/pitch change decreased with age over posterior regions, becoming more frontally specific; age-related change was diminished in the NF1 group. Whilst both groups detected changes in vowel and pitch, the NF1 group were largely slower to show a differentiated neural response. Auditory responses did not relate to later language, but were related to later ASD traits. Conclusions: These findings represent the first demonstration of atypical brain responses to sounds in infants with NF1 and suggest they may relate to the likelihood of later ASD.",

keywords = "Auditory processing, Autism spectrum disorder, Change detection, EEG, Habituation, Neurofibromatosis type 1",

author = "{the STAARS and EDEN Teams} and Jannath Begum-Ali and Anna Kolesnik-Taylor and Isabel Quiroz and Luke Mason and Shruti Garg and Jonathan Green and Johnson, {Mark H.} and Jones, {Emily J.H.} and Rebecca Holman and Sarah Kalwarowsky and Laura Pirazzoli and Chlo{\"e} Taylor and Grace Vassallo and Emma Burkitt-Wright and Judith Eelloo and Evans, {D. Gareth} and Siobhan West and Eileen Hupton and Lauren Lewis and Louise Robinson and Angus Dobbie and Ruth Drimer and Sharif, {Saghira Malik} and Helen Bethell and Rachel Jones and Susan Musson and Catherine Prem and Miranda Splitt and Karen Horridge and Diana Baralle and Carolyn Redman and Helen Tomkins",

note = "Funding Information: This work was supported by Action for Medical Research, Great Ormond Street Hospital Children{\textquoteright}s Charity and the Bailey Thomas Charitable Fund (GN2385), Rosetrees Trust (A2213), and the Economic and Social Research Council (ES/J500021/1; AK). This work was also supported by the EU-AIMS and AIMS-2-TRIALS programmes funded by the Innovative Medicines Initiative (IMI) Joint Undertaking Grant Nos. 115300 (MHJ) and No. 777394 (MHJ, EJHJ). Publisher Copyright: {\textcopyright} 2021, The Author(s).",

year = "2021",

month = dec,

doi = "10.1186/s11689-021-09364-3",

language = "English",

volume = "13",

journal = "Journal Of Neurodevelopmental Disorders",

issn = "1866-1947",

publisher = "Springer New York",

number = "1",

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TY - JOUR

T1 - Early differences in auditory processing relate to Autism Spectrum Disorder traits in infants with Neurofibromatosis Type I

AU - the STAARS and EDEN Teams

AU - Begum-Ali, Jannath

AU - Kolesnik-Taylor, Anna

AU - Quiroz, Isabel

AU - Mason, Luke

AU - Garg, Shruti

AU - Green, Jonathan

AU - Johnson, Mark H.

AU - Jones, Emily J.H.

AU - Holman, Rebecca

AU - Kalwarowsky, Sarah

AU - Pirazzoli, Laura

AU - Taylor, Chloë

AU - Vassallo, Grace

AU - Burkitt-Wright, Emma

AU - Eelloo, Judith

AU - Evans, D. Gareth

AU - West, Siobhan

AU - Hupton, Eileen

AU - Lewis, Lauren

AU - Robinson, Louise

AU - Dobbie, Angus

AU - Drimer, Ruth

AU - Sharif, Saghira Malik

AU - Bethell, Helen

AU - Jones, Rachel

AU - Musson, Susan

AU - Prem, Catherine

AU - Splitt, Miranda

AU - Horridge, Karen

AU - Baralle, Diana

AU - Redman, Carolyn

AU - Tomkins, Helen

N1 - Funding Information: This work was supported by Action for Medical Research, Great Ormond Street Hospital Children’s Charity and the Bailey Thomas Charitable Fund (GN2385), Rosetrees Trust (A2213), and the Economic and Social Research Council (ES/J500021/1; AK). This work was also supported by the EU-AIMS and AIMS-2-TRIALS programmes funded by the Innovative Medicines Initiative (IMI) Joint Undertaking Grant Nos. 115300 (MHJ) and No. 777394 (MHJ, EJHJ). Publisher Copyright: © 2021, The Author(s).

PY - 2021/12

Y1 - 2021/12

N2 - Background: Sensory modulation difficulties are common in children with conditions such as Autism Spectrum Disorder (ASD) and could contribute to other social and non-social symptoms. Positing a causal role for sensory processing differences requires observing atypical sensory reactivity prior to the emergence of other symptoms, which can be achieved through prospective studies. Methods: In this longitudinal study, we examined auditory repetition suppression and change detection at 5 and 10 months in infants with and without Neurofibromatosis Type 1 (NF1), a condition associated with higher likelihood of developing ASD. Results: In typically developing infants, suppression to vowel repetition and enhanced responses to vowel/pitch change decreased with age over posterior regions, becoming more frontally specific; age-related change was diminished in the NF1 group. Whilst both groups detected changes in vowel and pitch, the NF1 group were largely slower to show a differentiated neural response. Auditory responses did not relate to later language, but were related to later ASD traits. Conclusions: These findings represent the first demonstration of atypical brain responses to sounds in infants with NF1 and suggest they may relate to the likelihood of later ASD.

AB - Background: Sensory modulation difficulties are common in children with conditions such as Autism Spectrum Disorder (ASD) and could contribute to other social and non-social symptoms. Positing a causal role for sensory processing differences requires observing atypical sensory reactivity prior to the emergence of other symptoms, which can be achieved through prospective studies. Methods: In this longitudinal study, we examined auditory repetition suppression and change detection at 5 and 10 months in infants with and without Neurofibromatosis Type 1 (NF1), a condition associated with higher likelihood of developing ASD. Results: In typically developing infants, suppression to vowel repetition and enhanced responses to vowel/pitch change decreased with age over posterior regions, becoming more frontally specific; age-related change was diminished in the NF1 group. Whilst both groups detected changes in vowel and pitch, the NF1 group were largely slower to show a differentiated neural response. Auditory responses did not relate to later language, but were related to later ASD traits. Conclusions: These findings represent the first demonstration of atypical brain responses to sounds in infants with NF1 and suggest they may relate to the likelihood of later ASD.

KW - Auditory processing

KW - Autism spectrum disorder

KW - Change detection

KW - EEG

KW - Habituation

KW - Neurofibromatosis type 1

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U2 - 10.1186/s11689-021-09364-3

DO - 10.1186/s11689-021-09364-3

M3 - Article

C2 - 34049498

AN - SCOPUS:85107254140

SN - 1866-1947

VL - 13

JO - Journal Of Neurodevelopmental Disorders

JF - Journal Of Neurodevelopmental Disorders

IS - 1

M1 - 22

ER -

Early differences in auditory processing relate to Autism Spectrum Disorder traits in infants with Neurofibromatosis Type I

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