Early mechanical selection of cell extrusion and extrusion signaling in cancer

Saranne J Mitchell, Jody Rosenblatt

Research output: Contribution to journalReview articlepeer-review

9 Citations (Scopus)


Epithelial cells use the process of extrusion to promote cell death while preserving a tight barrier. To extrude, a cell and its neighbors contract actin and myosin circumferentially and basolaterally to seamlessly squeeze it out of the epithelium. Recent research highlights how early apical pulsatile contractions within the extruding cell might orchestrate contraction in three dimensions so that a cell extrudes out apically. Along with apical constrictions, studies of ion channels and mathematical modeling reveal how differential contraction between cells helps select specific cells to extrude. In addition, several studies have offered new insights into pathways that use extrusion to eliminate transformed cells or cause an aberrant form of extrusion that promotes cell invasion.

Original languageEnglish
Pages (from-to)36-40
Number of pages5
JournalCurrent Opinion in Cell Biology
Early online date24 May 2021
Publication statusPublished - Oct 2021


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