TY - JOUR
T1 - Early origins of respiratory disease
AU - Greenough, Anne
AU - Milner, Anthony David
N1 - Funding Information:
Research funding: Medical Research Council, National Institute for Health and Care Research, Biomedical Research Centre and the Charles Wolfson Charitable Trust.
Publisher Copyright:
© 2022 the author(s), published by De Gruyter, Berlin/Boston 2022.
PY - 2022
Y1 - 2022
N2 - Chronic respiratory morbidity is unfortunately common in childhood, particularly in those born very prematurely or with congenital anomalies affecting pulmonary development and those with sickle cell disease. Our research group, therefore, has focused on the early origins of chronic respiratory disease. This has included assessing antenatal diagnostic techniques and potentially therapeutic interventions in infants with congenital diaphragmatic hernia. Undertaking physiological studies, we have increased the understanding of the premature baby's response to resuscitation and evaluated interventions in the delivery suite. Mechanical ventilation modes have been optimised and randomised controlled trials (RCTs) with short- and long-term outcomes undertaken. Our studies highlighted respiratory syncytial virus lower respiratory tract infections (LRTIs) and other respiratory viral LRTIs had an adverse impact on respiratory outcomes of prematurely born infants, who we demonstrated have a functional and genetic predisposition to respiratory viral LRTIs. We have described the long-term respiratory outcomes for children with sickle cell disease and importantly identified influencing factors. In conclusion, it is essential to undertake long term follow up of infants at high risk of chronic respiratory morbidity if effective preventative strategies are to be developed.
AB - Chronic respiratory morbidity is unfortunately common in childhood, particularly in those born very prematurely or with congenital anomalies affecting pulmonary development and those with sickle cell disease. Our research group, therefore, has focused on the early origins of chronic respiratory disease. This has included assessing antenatal diagnostic techniques and potentially therapeutic interventions in infants with congenital diaphragmatic hernia. Undertaking physiological studies, we have increased the understanding of the premature baby's response to resuscitation and evaluated interventions in the delivery suite. Mechanical ventilation modes have been optimised and randomised controlled trials (RCTs) with short- and long-term outcomes undertaken. Our studies highlighted respiratory syncytial virus lower respiratory tract infections (LRTIs) and other respiratory viral LRTIs had an adverse impact on respiratory outcomes of prematurely born infants, who we demonstrated have a functional and genetic predisposition to respiratory viral LRTIs. We have described the long-term respiratory outcomes for children with sickle cell disease and importantly identified influencing factors. In conclusion, it is essential to undertake long term follow up of infants at high risk of chronic respiratory morbidity if effective preventative strategies are to be developed.
KW - congenital diaphragmatic hernia
KW - neonatal ventilation
KW - resuscitation
KW - sickle cell disease
UR - http://www.scopus.com/inward/record.url?scp=85133918418&partnerID=8YFLogxK
U2 - 10.1515/jpm-2022-0257
DO - 10.1515/jpm-2022-0257
M3 - Review article
C2 - 35786507
AN - SCOPUS:85133918418
SN - 0300-5577
JO - Journal of Perinatal Medicine
JF - Journal of Perinatal Medicine
ER -
