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Early Prediction of Hypoxic-Ischemic Brain Injury by a New Panel of Biomarkers in a Population of Term Newborns

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Early Prediction of Hypoxic-Ischemic Brain Injury by a New Panel of Biomarkers in a Population of Term Newborns. / Negro, Simona; Benders, Manon J.N.L.; Tataranno, Maria Luisa; Coviello, Caterina; de Vries, Linda S.; van Bel, Frank; Groenendaal, Floris; Longini, Mariangela; Proietti, Fabrizio; Belvisi, Elisa; Buonocore, Giuseppe; Perrone, Serafina.

In: Oxidative Medicine and Cellular Longevity, Vol. 2018, 28.06.2018.

Research output: Contribution to journalArticle

Harvard

Negro, S, Benders, MJNL, Tataranno, ML, Coviello, C, de Vries, LS, van Bel, F, Groenendaal, F, Longini, M, Proietti, F, Belvisi, E, Buonocore, G & Perrone, S 2018, 'Early Prediction of Hypoxic-Ischemic Brain Injury by a New Panel of Biomarkers in a Population of Term Newborns', Oxidative Medicine and Cellular Longevity, vol. 2018. https://doi.org/10.1155/2018/7608108

APA

Negro, S., Benders, M. J. N. L., Tataranno, M. L., Coviello, C., de Vries, L. S., van Bel, F., ... Perrone, S. (2018). Early Prediction of Hypoxic-Ischemic Brain Injury by a New Panel of Biomarkers in a Population of Term Newborns. Oxidative Medicine and Cellular Longevity, 2018. https://doi.org/10.1155/2018/7608108

Vancouver

Negro S, Benders MJNL, Tataranno ML, Coviello C, de Vries LS, van Bel F et al. Early Prediction of Hypoxic-Ischemic Brain Injury by a New Panel of Biomarkers in a Population of Term Newborns. Oxidative Medicine and Cellular Longevity. 2018 Jun 28;2018. https://doi.org/10.1155/2018/7608108

Author

Negro, Simona ; Benders, Manon J.N.L. ; Tataranno, Maria Luisa ; Coviello, Caterina ; de Vries, Linda S. ; van Bel, Frank ; Groenendaal, Floris ; Longini, Mariangela ; Proietti, Fabrizio ; Belvisi, Elisa ; Buonocore, Giuseppe ; Perrone, Serafina. / Early Prediction of Hypoxic-Ischemic Brain Injury by a New Panel of Biomarkers in a Population of Term Newborns. In: Oxidative Medicine and Cellular Longevity. 2018 ; Vol. 2018.

Bibtex Download

@article{10e2e499624a47e7be25aabf4ce5fdda,
title = "Early Prediction of Hypoxic-Ischemic Brain Injury by a New Panel of Biomarkers in a Population of Term Newborns",
abstract = "This research paper is aimed at evaluating the predictive role of a default panel of oxidative stress (OS) biomarkers for the early identification of infants at high risk of HIE and their validation through the correlation with MRI findings. A multicenter prospective observational study was performed between March 2012 and April 2015 in two European tertiary NICUs. Eighty-four term infants at risk for HIE (pH < 7, BE < -13 mmol/L, and 5' Apgar < 5) were enrolled. Three were excluded for chromosomal abnormalities and one due to lack of blood samples. The final population was divided according to the severity of perinatal hypoxia into 2 groups: mild/moderate HIE and severe HIE. Advanced oxidation protein products (AOPP), non-protein-bound iron (NPBI), and F2-isoprostanes (F2-IsoPs) were measured in blood samples at P1 (4-6 hours), P2 (24-72 hours), and P3 (5 days), in both groups. MRIs were scored for the severity of brain injury, using a modified Barkovich score. The mean GA was 39.8 weeks (SD 1.4) and the mean birth weight 3538 grams (SD 660); 37 were females and 43 males. Significantly lower 5' Apgar score, pH, and BE and higher Thompson score were found in group II compared to group I at birth. Group II showed significantly higher AOPP and NPBI levels than group I (mean (SD) AOPP: 15.7 (15.5) versus 34.1 (39.2), p = 0.033; NPBI 1.1 (2.5) versus 3.9 (4.4), p = 0.013) soon after birth (P1). No differences were observed in OS biomarker levels between the two groups at P2 and P3. A regression model, including adjustment for hypothermia treatment, gender, and time after birth, showed that AOPP levels and male gender were both risk factors for higher brain damage scores (AOPP: OR 3.6, 95{\%} CI (1.1-12.2) and gender: OR 5.6, 95{\%} CI (1.2-25.7), resp.). Newborns with severe asphyxia showed higher OS than those with mild asphyxia at birth. AOPP are significantly associated with the severity of brain injury assessed by MRI, especially in males.",
author = "Simona Negro and Benders, {Manon J.N.L.} and Tataranno, {Maria Luisa} and Caterina Coviello and {de Vries}, {Linda S.} and {van Bel}, Frank and Floris Groenendaal and Mariangela Longini and Fabrizio Proietti and Elisa Belvisi and Giuseppe Buonocore and Serafina Perrone",
year = "2018",
month = "6",
day = "28",
doi = "10.1155/2018/7608108",
language = "English",
volume = "2018",
journal = "Oxidative Medicine and Cellular Longevity",
issn = "1942-0900",
publisher = "Hindawi Publishing Corporation",

}

RIS (suitable for import to EndNote) Download

TY - JOUR

T1 - Early Prediction of Hypoxic-Ischemic Brain Injury by a New Panel of Biomarkers in a Population of Term Newborns

AU - Negro, Simona

AU - Benders, Manon J.N.L.

AU - Tataranno, Maria Luisa

AU - Coviello, Caterina

AU - de Vries, Linda S.

AU - van Bel, Frank

AU - Groenendaal, Floris

AU - Longini, Mariangela

AU - Proietti, Fabrizio

AU - Belvisi, Elisa

AU - Buonocore, Giuseppe

AU - Perrone, Serafina

PY - 2018/6/28

Y1 - 2018/6/28

N2 - This research paper is aimed at evaluating the predictive role of a default panel of oxidative stress (OS) biomarkers for the early identification of infants at high risk of HIE and their validation through the correlation with MRI findings. A multicenter prospective observational study was performed between March 2012 and April 2015 in two European tertiary NICUs. Eighty-four term infants at risk for HIE (pH < 7, BE < -13 mmol/L, and 5' Apgar < 5) were enrolled. Three were excluded for chromosomal abnormalities and one due to lack of blood samples. The final population was divided according to the severity of perinatal hypoxia into 2 groups: mild/moderate HIE and severe HIE. Advanced oxidation protein products (AOPP), non-protein-bound iron (NPBI), and F2-isoprostanes (F2-IsoPs) were measured in blood samples at P1 (4-6 hours), P2 (24-72 hours), and P3 (5 days), in both groups. MRIs were scored for the severity of brain injury, using a modified Barkovich score. The mean GA was 39.8 weeks (SD 1.4) and the mean birth weight 3538 grams (SD 660); 37 were females and 43 males. Significantly lower 5' Apgar score, pH, and BE and higher Thompson score were found in group II compared to group I at birth. Group II showed significantly higher AOPP and NPBI levels than group I (mean (SD) AOPP: 15.7 (15.5) versus 34.1 (39.2), p = 0.033; NPBI 1.1 (2.5) versus 3.9 (4.4), p = 0.013) soon after birth (P1). No differences were observed in OS biomarker levels between the two groups at P2 and P3. A regression model, including adjustment for hypothermia treatment, gender, and time after birth, showed that AOPP levels and male gender were both risk factors for higher brain damage scores (AOPP: OR 3.6, 95% CI (1.1-12.2) and gender: OR 5.6, 95% CI (1.2-25.7), resp.). Newborns with severe asphyxia showed higher OS than those with mild asphyxia at birth. AOPP are significantly associated with the severity of brain injury assessed by MRI, especially in males.

AB - This research paper is aimed at evaluating the predictive role of a default panel of oxidative stress (OS) biomarkers for the early identification of infants at high risk of HIE and their validation through the correlation with MRI findings. A multicenter prospective observational study was performed between March 2012 and April 2015 in two European tertiary NICUs. Eighty-four term infants at risk for HIE (pH < 7, BE < -13 mmol/L, and 5' Apgar < 5) were enrolled. Three were excluded for chromosomal abnormalities and one due to lack of blood samples. The final population was divided according to the severity of perinatal hypoxia into 2 groups: mild/moderate HIE and severe HIE. Advanced oxidation protein products (AOPP), non-protein-bound iron (NPBI), and F2-isoprostanes (F2-IsoPs) were measured in blood samples at P1 (4-6 hours), P2 (24-72 hours), and P3 (5 days), in both groups. MRIs were scored for the severity of brain injury, using a modified Barkovich score. The mean GA was 39.8 weeks (SD 1.4) and the mean birth weight 3538 grams (SD 660); 37 were females and 43 males. Significantly lower 5' Apgar score, pH, and BE and higher Thompson score were found in group II compared to group I at birth. Group II showed significantly higher AOPP and NPBI levels than group I (mean (SD) AOPP: 15.7 (15.5) versus 34.1 (39.2), p = 0.033; NPBI 1.1 (2.5) versus 3.9 (4.4), p = 0.013) soon after birth (P1). No differences were observed in OS biomarker levels between the two groups at P2 and P3. A regression model, including adjustment for hypothermia treatment, gender, and time after birth, showed that AOPP levels and male gender were both risk factors for higher brain damage scores (AOPP: OR 3.6, 95% CI (1.1-12.2) and gender: OR 5.6, 95% CI (1.2-25.7), resp.). Newborns with severe asphyxia showed higher OS than those with mild asphyxia at birth. AOPP are significantly associated with the severity of brain injury assessed by MRI, especially in males.

UR - http://www.scopus.com/inward/record.url?scp=85055205705&partnerID=8YFLogxK

U2 - 10.1155/2018/7608108

DO - 10.1155/2018/7608108

M3 - Article

C2 - 30050660

AN - SCOPUS:85055205705

VL - 2018

JO - Oxidative Medicine and Cellular Longevity

JF - Oxidative Medicine and Cellular Longevity

SN - 1942-0900

ER -

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