Early variations in white matter microstructure and depression outcome in adolescents with subthreshold depression

IMAGEN Consortium

doi:10.1176/appi.ajp.2018.17070825

Early variations in white matter microstructure and depression outcome in adolescents with subthreshold depression

IMAGEN Consortium

Research output: Contribution to journal › Article › peer-review

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Abstract

Objective: White matter microstructure alterations have recently been associated with depressive episodes during adolescence, but it is unknown whether they predate depression. The authors investigated whether subthreshold depression in adolescence is associated with white matter microstructure variations and whether they relate to depression outcome. Method: Adolescents with subthreshold depression (N=96) and healthy control subjects (N=336) drawn from a community-based cohort were compared using diffusion tensor imaging and whole brain tract-based spatial statistics (TBSS) at age 14 to assess white matter microstructure. They were followed up at age 16 to assess depression. Probabilistic tractography was used to reconstruct white matter streamlines spreading from the regions identified in the TBSS analysis and along bundles implicated in emotion regulation, the uncinate fasciculus and the cingulum. The authors searched for mediating effects of white matter microstructure on the relationship between baseline subthreshold depression and depression at follow-up, and then explored the specificity of the findings. Results: Lower fractional anisotropy (FA) and higher radial diffusivity were found in the anterior corpus callosum in the adolescents with subthreshold depression. Tractography analysis showed that they also had lower FA in the right cingulum streamlines, along with lower FA and higher mean diffusivity in tracts connecting the corpus callosum to the anterior cingulate cortex. The relation between subthreshold depression at baseline and depression at follow-up was mediated by FA values in the latter tracts, and lower FA values in those tracts distinctively predicted higher individual risk for depression. Conclusions: Early FA variations in tracts projecting from the corpus callosum to the anterior cingulate cortex may denote a higher risk of transition to depression in adolescents.

Original language	English
Pages (from-to)	1255-1264
Number of pages	10
Journal	American Journal of Psychiatry
Volume	175
Issue number	12
Early online date	16 Aug 2018
DOIs	https://doi.org/10.1176/appi.ajp.2018.17070825
Publication status	Published - 1 Dec 2018

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10.1176/appi.ajp.2018.17070825

Early Variations in White Matter_VULSER_Accepted21May18_GREEN AAMAccepted author manuscript, 477 KB

http://eprints.nottingham.ac.uk/id/eprint/51953

Cite this

@article{4311d4a9de5a4cdb9be7ff0e0a68eef8,

title = "Early variations in white matter microstructure and depression outcome in adolescents with subthreshold depression",

abstract = "Objective: White matter microstructure alterations have recently been associated with depressive episodes during adolescence, but it is unknown whether they predate depression. The authors investigated whether subthreshold depression in adolescence is associated with white matter microstructure variations and whether they relate to depression outcome. Method: Adolescents with subthreshold depression (N=96) and healthy control subjects (N=336) drawn from a community-based cohort were compared using diffusion tensor imaging and whole brain tract-based spatial statistics (TBSS) at age 14 to assess white matter microstructure. They were followed up at age 16 to assess depression. Probabilistic tractography was used to reconstruct white matter streamlines spreading from the regions identified in the TBSS analysis and along bundles implicated in emotion regulation, the uncinate fasciculus and the cingulum. The authors searched for mediating effects of white matter microstructure on the relationship between baseline subthreshold depression and depression at follow-up, and then explored the specificity of the findings. Results: Lower fractional anisotropy (FA) and higher radial diffusivity were found in the anterior corpus callosum in the adolescents with subthreshold depression. Tractography analysis showed that they also had lower FA in the right cingulum streamlines, along with lower FA and higher mean diffusivity in tracts connecting the corpus callosum to the anterior cingulate cortex. The relation between subthreshold depression at baseline and depression at follow-up was mediated by FA values in the latter tracts, and lower FA values in those tracts distinctively predicted higher individual risk for depression. Conclusions: Early FA variations in tracts projecting from the corpus callosum to the anterior cingulate cortex may denote a higher risk of transition to depression in adolescents.",

author = "{IMAGEN Consortium} and H{\'e}l{\`e}ne Vulser and Martinot, {Marie Laure Paill{\`e}re} and Eric Artiges and Ruben Miranda and Jani Penttil{\"a} and Yvonne Grimmer and {Van Noort}, {Betteke M.} and Argyris Stringaris and Maren Struve and Tahmine Fadai and Viola Kappel and Robert Goodman and Eleni Tzavara and Charbel Massaad and Tobias Banaschewski and Barker, {Gareth J.} and Bokde, {Arun L.W.} and Uli Bromberg and R{\"u}diger Br{\"u}hl and Christian B{\"u}chel and Anna Cattrell and Patricia Conrod and Sylvane Desrivi{\`e}res and Herta Flor and Vincent Frouin and Juergen Gallinat and Hugh Garavan and Penny Gowland and Andreas Heinz and Frauke Nees and Dimitri Papadopoulos-Orfanos and Tomas Paus and Luise Poustka and Sarah Rodehacke and Smolka, {Michael N.} and Henrik Walter and Robert Whelan and Gunter Schumann and Martinot, {Jean Luc} and Herv{\'e} Lemaitre",

year = "2018",

month = dec,

day = "1",

doi = "10.1176/appi.ajp.2018.17070825",

language = "English",

volume = "175",

pages = "1255--1264",

journal = "American Journal of Psychiatry",

issn = "0002-953X",

publisher = "American Psychiatric Publishing Inc.",

number = "12",

}

TY - JOUR

T1 - Early variations in white matter microstructure and depression outcome in adolescents with subthreshold depression

AU - IMAGEN Consortium

AU - Vulser, Hélène

AU - Martinot, Marie Laure Paillère

AU - Artiges, Eric

AU - Miranda, Ruben

AU - Penttilä, Jani

AU - Grimmer, Yvonne

AU - Van Noort, Betteke M.

AU - Stringaris, Argyris

AU - Struve, Maren

AU - Fadai, Tahmine

AU - Kappel, Viola

AU - Goodman, Robert

AU - Tzavara, Eleni

AU - Massaad, Charbel

AU - Banaschewski, Tobias

AU - Barker, Gareth J.

AU - Bokde, Arun L.W.

AU - Bromberg, Uli

AU - Brühl, Rüdiger

AU - Büchel, Christian

AU - Cattrell, Anna

AU - Conrod, Patricia

AU - Desrivières, Sylvane

AU - Flor, Herta

AU - Frouin, Vincent

AU - Gallinat, Juergen

AU - Garavan, Hugh

AU - Gowland, Penny

AU - Heinz, Andreas

AU - Nees, Frauke

AU - Papadopoulos-Orfanos, Dimitri

AU - Paus, Tomas

AU - Poustka, Luise

AU - Rodehacke, Sarah

AU - Smolka, Michael N.

AU - Walter, Henrik

AU - Whelan, Robert

AU - Schumann, Gunter

AU - Martinot, Jean Luc

AU - Lemaitre, Hervé

PY - 2018/12/1

Y1 - 2018/12/1

N2 - Objective: White matter microstructure alterations have recently been associated with depressive episodes during adolescence, but it is unknown whether they predate depression. The authors investigated whether subthreshold depression in adolescence is associated with white matter microstructure variations and whether they relate to depression outcome. Method: Adolescents with subthreshold depression (N=96) and healthy control subjects (N=336) drawn from a community-based cohort were compared using diffusion tensor imaging and whole brain tract-based spatial statistics (TBSS) at age 14 to assess white matter microstructure. They were followed up at age 16 to assess depression. Probabilistic tractography was used to reconstruct white matter streamlines spreading from the regions identified in the TBSS analysis and along bundles implicated in emotion regulation, the uncinate fasciculus and the cingulum. The authors searched for mediating effects of white matter microstructure on the relationship between baseline subthreshold depression and depression at follow-up, and then explored the specificity of the findings. Results: Lower fractional anisotropy (FA) and higher radial diffusivity were found in the anterior corpus callosum in the adolescents with subthreshold depression. Tractography analysis showed that they also had lower FA in the right cingulum streamlines, along with lower FA and higher mean diffusivity in tracts connecting the corpus callosum to the anterior cingulate cortex. The relation between subthreshold depression at baseline and depression at follow-up was mediated by FA values in the latter tracts, and lower FA values in those tracts distinctively predicted higher individual risk for depression. Conclusions: Early FA variations in tracts projecting from the corpus callosum to the anterior cingulate cortex may denote a higher risk of transition to depression in adolescents.

AB - Objective: White matter microstructure alterations have recently been associated with depressive episodes during adolescence, but it is unknown whether they predate depression. The authors investigated whether subthreshold depression in adolescence is associated with white matter microstructure variations and whether they relate to depression outcome. Method: Adolescents with subthreshold depression (N=96) and healthy control subjects (N=336) drawn from a community-based cohort were compared using diffusion tensor imaging and whole brain tract-based spatial statistics (TBSS) at age 14 to assess white matter microstructure. They were followed up at age 16 to assess depression. Probabilistic tractography was used to reconstruct white matter streamlines spreading from the regions identified in the TBSS analysis and along bundles implicated in emotion regulation, the uncinate fasciculus and the cingulum. The authors searched for mediating effects of white matter microstructure on the relationship between baseline subthreshold depression and depression at follow-up, and then explored the specificity of the findings. Results: Lower fractional anisotropy (FA) and higher radial diffusivity were found in the anterior corpus callosum in the adolescents with subthreshold depression. Tractography analysis showed that they also had lower FA in the right cingulum streamlines, along with lower FA and higher mean diffusivity in tracts connecting the corpus callosum to the anterior cingulate cortex. The relation between subthreshold depression at baseline and depression at follow-up was mediated by FA values in the latter tracts, and lower FA values in those tracts distinctively predicted higher individual risk for depression. Conclusions: Early FA variations in tracts projecting from the corpus callosum to the anterior cingulate cortex may denote a higher risk of transition to depression in adolescents.

UR - http://www.scopus.com/inward/record.url?scp=85057593778&partnerID=8YFLogxK

U2 - 10.1176/appi.ajp.2018.17070825

DO - 10.1176/appi.ajp.2018.17070825

M3 - Article

C2 - 30111185

AN - SCOPUS:85057593778

SN - 0002-953X

VL - 175

SP - 1255

EP - 1264

JO - American Journal of Psychiatry

JF - American Journal of Psychiatry

IS - 12

ER -

Early variations in white matter microstructure and depression outcome in adolescents with subthreshold depression

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