East Coast fever, a neglected tropical disease with an outdated vaccine approach?

TY - JOUR

T1 - East Coast fever, a neglected tropical disease with an outdated vaccine approach?

AU - Kolakowski, Jeannine

AU - Connelley, Tim

AU - Lukacik, Petra

AU - Pfuhl, Mark

AU - Werling, Dirk

N1 - Funding Information: We thank Dr N. Werling for carefully reading the manuscript. The authors have no competing interests to declare. Publisher Copyright: © 2022 The Authors

PY - 2022/11

Y1 - 2022/11

N2 - Since its discovery, bovine theileriosis has caused major socioeconomic losses in sub-Saharan Africa. Acaricide resistance of the intermediate host, paucity of therapeutics, and lack of sufficiently cross-protective vaccines increase the risk of parasite spread due to global warming. Here, we highlight three important areas that require investigation to develop next-generation vaccines.

AB - Since its discovery, bovine theileriosis has caused major socioeconomic losses in sub-Saharan Africa. Acaricide resistance of the intermediate host, paucity of therapeutics, and lack of sufficiently cross-protective vaccines increase the risk of parasite spread due to global warming. Here, we highlight three important areas that require investigation to develop next-generation vaccines.

KW - cellular immunity

KW - drug resistance

KW - glycobiology

KW - infection and treatment method (ITM)

KW - protein modelling

KW - Theileria parva

UR - http://www.scopus.com/inward/record.url?scp=85136686862&partnerID=8YFLogxK

U2 - 10.1016/j.pt.2022.08.006

DO - 10.1016/j.pt.2022.08.006

M3 - Short survey

AN - SCOPUS:85136686862

SN - 1471-4922

VL - 38

SP - 930

EP - 932

JO - TRENDS IN PARASITOLOGY

JF - TRENDS IN PARASITOLOGY

IS - 11

ER -