Edited magnetic resonance spectroscopy in the neonatal brain

Yulu Song; Peter J. Lally; Maria Yanez Lopez; Georg Oeltzschner; Mary Beth Nebel; Borjan Gagoski; Steven Kecskemeti; Steve C.N. Hui; Helge J. Zöllner; Deepika Shukla; Tomoki Arichi; Enrico De Vita; Vivek Yedavalli; Sudhin Thayyil; Daniele Fallin; Douglas C. Dean; P. Ellen Grant; Jessica L. Wisnowski; Richard A.E. Edden

doi:10.1007/s00234-021-02821-9

Edited magnetic resonance spectroscopy in the neonatal brain

Yulu Song, Peter J. Lally, Maria Yanez Lopez, Georg Oeltzschner, Mary Beth Nebel, Borjan Gagoski, Steven Kecskemeti, Steve C.N. Hui, Helge J. Zöllner, Deepika Shukla, Tomoki Arichi, Enrico De Vita, Vivek Yedavalli, Sudhin Thayyil, Daniele Fallin, Douglas C. Dean, P. Ellen Grant, Jessica L. Wisnowski, Richard A.E. Edden^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

J-difference-edited spectroscopy is a valuable approach for the detection of low-concentration metabolites with magnetic resonance spectroscopy (MRS). Currently, few edited MRS studies are performed in neonates due to suboptimal signal-to-noise ratio, relatively long acquisition times, and vulnerability to motion artifacts. Nonetheless, the technique presents an exciting opportunity in pediatric imaging research to study rapid maturational changes of neurotransmitter systems and other metabolic systems in early postnatal life. Studying these metabolic processes is vital to understanding the widespread and rapid structural and functional changes that occur in the first years of life. The overarching goal of this review is to provide an introduction to edited MRS for neonates, including the current state-of-the-art in editing methods and editable metabolites, as well as to review the current literature applying edited MRS to the neonatal brain. Existing challenges and future opportunities, including the lack of age-specific reference data, are also discussed.

Original language	English
Journal	Neuroradiology
Early online date	15 Oct 2021
DOIs	https://doi.org/10.1007/s00234-021-02821-9
Publication status	E-pub ahead of print - 15 Oct 2021

Keywords

Edited MRS
J-difference editing
Low-concentration metabolites
Neonatal brain
Relaxation time

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10.1007/s00234-021-02821-9

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Song, Y., Lally, P. J., Yanez Lopez, M., Oeltzschner, G., Nebel, M. B., Gagoski, B., Kecskemeti, S., Hui, S. C. N., Zöllner, H. J., Shukla, D., Arichi, T., De Vita, E., Yedavalli, V., Thayyil, S., Fallin, D., Dean, D. C., Grant, P. E., Wisnowski, J. L., & Edden, R. A. E. (2021). Edited magnetic resonance spectroscopy in the neonatal brain. Neuroradiology. Advance online publication. https://doi.org/10.1007/s00234-021-02821-9

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title = "Edited magnetic resonance spectroscopy in the neonatal brain",

abstract = "J-difference-edited spectroscopy is a valuable approach for the detection of low-concentration metabolites with magnetic resonance spectroscopy (MRS). Currently, few edited MRS studies are performed in neonates due to suboptimal signal-to-noise ratio, relatively long acquisition times, and vulnerability to motion artifacts. Nonetheless, the technique presents an exciting opportunity in pediatric imaging research to study rapid maturational changes of neurotransmitter systems and other metabolic systems in early postnatal life. Studying these metabolic processes is vital to understanding the widespread and rapid structural and functional changes that occur in the first years of life. The overarching goal of this review is to provide an introduction to edited MRS for neonates, including the current state-of-the-art in editing methods and editable metabolites, as well as to review the current literature applying edited MRS to the neonatal brain. Existing challenges and future opportunities, including the lack of age-specific reference data, are also discussed.",

keywords = "Edited MRS, J-difference editing, Low-concentration metabolites, Neonatal brain, Relaxation time",

author = "Yulu Song and Lally, {Peter J.} and {Yanez Lopez}, Maria and Georg Oeltzschner and Nebel, {Mary Beth} and Borjan Gagoski and Steven Kecskemeti and Hui, {Steve C.N.} and Z{\"o}llner, {Helge J.} and Deepika Shukla and Tomoki Arichi and {De Vita}, Enrico and Vivek Yedavalli and Sudhin Thayyil and Daniele Fallin and Dean, {Douglas C.} and Grant, {P. Ellen} and Wisnowski, {Jessica L.} and Edden, {Richard A.E.}",

note = "Funding Information: This work is supported by National Institutes of Health (NIH) grants R01 EB016089; R01 EB023963; R21 HD100869; P41 EB031771; R00 AG062230; 1R34DA050292-01; K23 HD099309. Funding Information: This work is also funded in part through a project grant awarded by Action Medical Research [GN 2728], a Medical Research Council (MRC) transition support fellowship [MR/V 036,874/1], and the Wellcome Engineering and Physical Sciences Research Council (EPSRC) Centre for Medical Engineering at Kings College London [WT 203,148/Z/16/Z]. Publisher Copyright: {\textcopyright} 2021, The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.",

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AU - Song, Yulu

AU - Lally, Peter J.

AU - Yanez Lopez, Maria

AU - Oeltzschner, Georg

AU - Nebel, Mary Beth

AU - Gagoski, Borjan

AU - Kecskemeti, Steven

AU - Hui, Steve C.N.

AU - Zöllner, Helge J.

AU - Shukla, Deepika

AU - Arichi, Tomoki

AU - De Vita, Enrico

AU - Yedavalli, Vivek

AU - Thayyil, Sudhin

AU - Fallin, Daniele

AU - Dean, Douglas C.

AU - Grant, P. Ellen

AU - Wisnowski, Jessica L.

AU - Edden, Richard A.E.

N1 - Funding Information: This work is supported by National Institutes of Health (NIH) grants R01 EB016089; R01 EB023963; R21 HD100869; P41 EB031771; R00 AG062230; 1R34DA050292-01; K23 HD099309. Funding Information: This work is also funded in part through a project grant awarded by Action Medical Research [GN 2728], a Medical Research Council (MRC) transition support fellowship [MR/V 036,874/1], and the Wellcome Engineering and Physical Sciences Research Council (EPSRC) Centre for Medical Engineering at Kings College London [WT 203,148/Z/16/Z]. Publisher Copyright: © 2021, The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.

PY - 2021/10/15

Y1 - 2021/10/15

N2 - J-difference-edited spectroscopy is a valuable approach for the detection of low-concentration metabolites with magnetic resonance spectroscopy (MRS). Currently, few edited MRS studies are performed in neonates due to suboptimal signal-to-noise ratio, relatively long acquisition times, and vulnerability to motion artifacts. Nonetheless, the technique presents an exciting opportunity in pediatric imaging research to study rapid maturational changes of neurotransmitter systems and other metabolic systems in early postnatal life. Studying these metabolic processes is vital to understanding the widespread and rapid structural and functional changes that occur in the first years of life. The overarching goal of this review is to provide an introduction to edited MRS for neonates, including the current state-of-the-art in editing methods and editable metabolites, as well as to review the current literature applying edited MRS to the neonatal brain. Existing challenges and future opportunities, including the lack of age-specific reference data, are also discussed.

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KW - Edited MRS

KW - J-difference editing

KW - Low-concentration metabolites

KW - Neonatal brain

KW - Relaxation time

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DO - 10.1007/s00234-021-02821-9

M3 - Article

AN - SCOPUS:85117081987

SN - 0028-3940

JO - Neuroradiology

JF - Neuroradiology

ER -

Edited magnetic resonance spectroscopy in the neonatal brain

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Keywords

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