TY - JOUR
T1 - Editorial
T2 - Does the polygenic revolution herald a watershed in the study of GE interplay in developmental psychopathology? Some considerations for the Special Issue reader
AU - Barker, Edward D.
AU - Maughan, Barbara
AU - Allegrini, Andrea
AU - Pingault, Jean Baptiste
AU - Sonuga-Barke, Edmund
N1 - Funding Information:
Edmund Sonuga-Barke has received consultancy from Neurotech Solutions, grant funding from QB-Tech and speaker fees from Takeda and Medice. He is the editor-in-chief of the Journal of Child Psychology & Psychiatry from whom he receives an honorarium. His research is supported by the Maudsley NIHR BRC, the ESRC, MRC and NIHR. The remaining authors have declared that they have no competing or potential conflicts of interest.
Funding Information:
Edmund Sonuga‐Barke has received consultancy from Neurotech Solutions, grant funding from QB‐Tech and speaker fees from Takeda and Medice. He is the editor‐in‐chief of the Journal of Child Psychology & Psychiatry from whom he receives an honorarium. His research is supported by the Maudsley NIHR BRC, the ESRC, MRC and NIHR. The remaining authors have declared that they have no competing or potential conflicts of interest.
Publisher Copyright:
© 2022 Association for Child and Adolescent Mental Health.
PY - 2022/10
Y1 - 2022/10
N2 - The primary goal motivating the scientific field of Developmental Psychopathology is to discover why some individuals develop mental health and neuro-developmental difficulties while others do not. This is not simply a ‘blue skies’ preoccupation: the underlying hope, of course, is to translate such discoveries to the benefit of individuals, families and communities, reducing poor outcomes for those at risk and – in the best case scenario – ensuring that they thrive. A core tenet of the bio-psycho-social framework within which this field of enquiry operates is that children's difficulties are determined by the interplay of predisposing genetic risk and resilience factors and the environments and experiences to which individuals are exposed. From this perspective, understanding gene–environment (GE) interplay is a necessary condition for explaining and, as importantly predicting, why one individual is at risk while another is not. If we believe this, then the risk calculators designed to show who will and will not get a particular disorder – all the rage at the moment – are doomed to fail until they can go beyond modelling the main effects of genes and environments, and reliably estimate GE processes too. Despite significant progress, we remain a considerable way off cracking this problem.
AB - The primary goal motivating the scientific field of Developmental Psychopathology is to discover why some individuals develop mental health and neuro-developmental difficulties while others do not. This is not simply a ‘blue skies’ preoccupation: the underlying hope, of course, is to translate such discoveries to the benefit of individuals, families and communities, reducing poor outcomes for those at risk and – in the best case scenario – ensuring that they thrive. A core tenet of the bio-psycho-social framework within which this field of enquiry operates is that children's difficulties are determined by the interplay of predisposing genetic risk and resilience factors and the environments and experiences to which individuals are exposed. From this perspective, understanding gene–environment (GE) interplay is a necessary condition for explaining and, as importantly predicting, why one individual is at risk while another is not. If we believe this, then the risk calculators designed to show who will and will not get a particular disorder – all the rage at the moment – are doomed to fail until they can go beyond modelling the main effects of genes and environments, and reliably estimate GE processes too. Despite significant progress, we remain a considerable way off cracking this problem.
UR - http://www.scopus.com/inward/record.url?scp=85138196594&partnerID=8YFLogxK
U2 - 10.1111/jcpp.13692
DO - 10.1111/jcpp.13692
M3 - Editorial
C2 - 36123310
AN - SCOPUS:85138196594
SN - 0021-9630
VL - 63
SP - 1107
EP - 1110
JO - Journal of Child Psychology and Psychiatry and Allied Disciplines
JF - Journal of Child Psychology and Psychiatry and Allied Disciplines
IS - 10
ER -
