Abstract
Objectives Myocardial blood flow (MBF) imaging is used in patients with suspected cardiac sarcoidosis, and also in stress/rest studies. The accuracy of MBF is dependent on imaging parameters such as new reconstruction methodologies. In this work, we aim to assess the impact of a novel PET reconstruction algorithm (Bayesian penalized likelihood – BPL) on the values determined from the calculation of [13N]-NH3 MBF values.
Methods. Data from 21 patients undergoing rest MBF evaluation [13N]-NH3 as part of sarcoidosis imaging were retrospectively analyzed. Each scan was reconstructed with a range of BPL coefficients (1-500), and standard clinical FBP and OSEM reconstructions. MBF values were calculated via an automated software routine for all datasets.
Results. Reconstruction of [13N]-NH3 dynamic data using the BPL, OSEM, or FBP reconstruction showed no quantitative differences for the calculation of territorial or global MBF (p=0.97). Image noise was lower using OSEM or BPL reconstructions than FBP and noise from BPL reached levels seen in OSEM images between B=300 and B=400. Intra-subject differences between all reconstructions over all patients over all cardiac territories showed a maximum coefficient of variation of 9.74%.
Conclusion. Quantitation of MBF via kinetic modeling of cardiac rest MBF by [13N]-NH3 is minimally affected by the use of a BPL reconstruction technique with BPL images presenting with less noise.
Methods. Data from 21 patients undergoing rest MBF evaluation [13N]-NH3 as part of sarcoidosis imaging were retrospectively analyzed. Each scan was reconstructed with a range of BPL coefficients (1-500), and standard clinical FBP and OSEM reconstructions. MBF values were calculated via an automated software routine for all datasets.
Results. Reconstruction of [13N]-NH3 dynamic data using the BPL, OSEM, or FBP reconstruction showed no quantitative differences for the calculation of territorial or global MBF (p=0.97). Image noise was lower using OSEM or BPL reconstructions than FBP and noise from BPL reached levels seen in OSEM images between B=300 and B=400. Intra-subject differences between all reconstructions over all patients over all cardiac territories showed a maximum coefficient of variation of 9.74%.
Conclusion. Quantitation of MBF via kinetic modeling of cardiac rest MBF by [13N]-NH3 is minimally affected by the use of a BPL reconstruction technique with BPL images presenting with less noise.
Original language | English |
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Journal | Journal of Nuclear Cardiology |
Early online date | 19 Jul 2016 |
DOIs | |
Publication status | E-pub ahead of print - 19 Jul 2016 |