Effect of class IV laser therapy on chemotherapy-induced oral mucositis: A clinical and experimental study

Giulia Ottaviani; Margherita Gobbo; Mauro Sturnega; Valentina Martinelli; Miguel Mano; Fabrizio Zanconati; Rossana Bussani; Giuseppe Perinetti; Carlin S. Long; Roberto Di Lenarda; Mauro Giacca; Matteo Biasotto; Serena Zacchigna

doi:10.1016/j.ajpath.2013.09.003

Effect of class IV laser therapy on chemotherapy-induced oral mucositis: A clinical and experimental study

Giulia Ottaviani, Margherita Gobbo, Mauro Sturnega, Valentina Martinelli, Miguel Mano, Fabrizio Zanconati, Rossana Bussani, Giuseppe Perinetti, Carlin S. Long, Roberto Di Lenarda, Mauro Giacca, Matteo Biasotto, Serena Zacchigna^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

46 Citations (Scopus)

Abstract

Oral mucositis (OM) is a serious and acute side effect in patients with cancer who receive chemotherapy or radiotherapy, often leading to the suspension of therapy and a need for opioid analgesic and enteral/parenteral nutrition, with an effect on patient survival. Among the various interventions proposed in OM management, laser therapy is becoming a recommended treatment option but has limitations due to its heterogeneous laser parameters. Here, we report on our successful clinical experience on the use of class IV laser therapy to treat OM induced by different chemotherapy regimens. To shed light on the mechanisms of action of laser therapy in improving OM resolution, we have developed an animal model of chemotherapy-induced OM, in which we compare the efficacy of the standard low-power laser therapy protocol with an innovative protocol, defined as high-power laser therapy. We show that high-power laser therapy is more effective than low-power laser therapy in improving OM lesion healing, reducing the inflammatory burden, and preserving tissue integrity. In addition, high-power laser therapy has been particularly effective in promoting the formation of new arterioles within the granulation tissue. Our results provide important insights into the mechanism of action of biostimulating laser therapy on OM in vivo and pave a way for clinical experimentation with the use of high-power laser therapy.

Original language	English
Pages (from-to)	1747-1757
Number of pages	11
Journal	American Journal of Pathology
Volume	183
Issue number	6
DOIs	https://doi.org/10.1016/j.ajpath.2013.09.003
Publication status	Published - 1 Dec 2013

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.ajpath.2013.09.003

Cite this

Ottaviani, G., Gobbo, M., Sturnega, M., Martinelli, V., Mano, M., Zanconati, F., Bussani, R., Perinetti, G., Long, C. S., Di Lenarda, R., Giacca, M., Biasotto, M., & Zacchigna, S. (2013). Effect of class IV laser therapy on chemotherapy-induced oral mucositis: A clinical and experimental study. American Journal of Pathology, 183(6), 1747-1757. https://doi.org/10.1016/j.ajpath.2013.09.003

@article{d889830c199b49c994d469e4711411c8,

title = "Effect of class IV laser therapy on chemotherapy-induced oral mucositis: A clinical and experimental study",

abstract = "Oral mucositis (OM) is a serious and acute side effect in patients with cancer who receive chemotherapy or radiotherapy, often leading to the suspension of therapy and a need for opioid analgesic and enteral/parenteral nutrition, with an effect on patient survival. Among the various interventions proposed in OM management, laser therapy is becoming a recommended treatment option but has limitations due to its heterogeneous laser parameters. Here, we report on our successful clinical experience on the use of class IV laser therapy to treat OM induced by different chemotherapy regimens. To shed light on the mechanisms of action of laser therapy in improving OM resolution, we have developed an animal model of chemotherapy-induced OM, in which we compare the efficacy of the standard low-power laser therapy protocol with an innovative protocol, defined as high-power laser therapy. We show that high-power laser therapy is more effective than low-power laser therapy in improving OM lesion healing, reducing the inflammatory burden, and preserving tissue integrity. In addition, high-power laser therapy has been particularly effective in promoting the formation of new arterioles within the granulation tissue. Our results provide important insights into the mechanism of action of biostimulating laser therapy on OM in vivo and pave a way for clinical experimentation with the use of high-power laser therapy.",

author = "Giulia Ottaviani and Margherita Gobbo and Mauro Sturnega and Valentina Martinelli and Miguel Mano and Fabrizio Zanconati and Rossana Bussani and Giuseppe Perinetti and Long, {Carlin S.} and {Di Lenarda}, Roberto and Mauro Giacca and Matteo Biasotto and Serena Zacchigna",

year = "2013",

month = dec,

day = "1",

doi = "10.1016/j.ajpath.2013.09.003",

language = "English",

volume = "183",

pages = "1747--1757",

journal = "American Journal of Pathology",

issn = "0002-9440",

publisher = "American Society for Investigative Pathology (ASIP)",

number = "6",

}

Ottaviani, G, Gobbo, M, Sturnega, M, Martinelli, V, Mano, M, Zanconati, F, Bussani, R, Perinetti, G, Long, CS, Di Lenarda, R, Giacca, M, Biasotto, M & Zacchigna, S 2013, 'Effect of class IV laser therapy on chemotherapy-induced oral mucositis: A clinical and experimental study', American Journal of Pathology, vol. 183, no. 6, pp. 1747-1757. https://doi.org/10.1016/j.ajpath.2013.09.003

TY - JOUR

T1 - Effect of class IV laser therapy on chemotherapy-induced oral mucositis

T2 - A clinical and experimental study

AU - Ottaviani, Giulia

AU - Gobbo, Margherita

AU - Sturnega, Mauro

AU - Martinelli, Valentina

AU - Mano, Miguel

AU - Zanconati, Fabrizio

AU - Bussani, Rossana

AU - Perinetti, Giuseppe

AU - Long, Carlin S.

AU - Di Lenarda, Roberto

AU - Giacca, Mauro

AU - Biasotto, Matteo

AU - Zacchigna, Serena

PY - 2013/12/1

Y1 - 2013/12/1

N2 - Oral mucositis (OM) is a serious and acute side effect in patients with cancer who receive chemotherapy or radiotherapy, often leading to the suspension of therapy and a need for opioid analgesic and enteral/parenteral nutrition, with an effect on patient survival. Among the various interventions proposed in OM management, laser therapy is becoming a recommended treatment option but has limitations due to its heterogeneous laser parameters. Here, we report on our successful clinical experience on the use of class IV laser therapy to treat OM induced by different chemotherapy regimens. To shed light on the mechanisms of action of laser therapy in improving OM resolution, we have developed an animal model of chemotherapy-induced OM, in which we compare the efficacy of the standard low-power laser therapy protocol with an innovative protocol, defined as high-power laser therapy. We show that high-power laser therapy is more effective than low-power laser therapy in improving OM lesion healing, reducing the inflammatory burden, and preserving tissue integrity. In addition, high-power laser therapy has been particularly effective in promoting the formation of new arterioles within the granulation tissue. Our results provide important insights into the mechanism of action of biostimulating laser therapy on OM in vivo and pave a way for clinical experimentation with the use of high-power laser therapy.

AB - Oral mucositis (OM) is a serious and acute side effect in patients with cancer who receive chemotherapy or radiotherapy, often leading to the suspension of therapy and a need for opioid analgesic and enteral/parenteral nutrition, with an effect on patient survival. Among the various interventions proposed in OM management, laser therapy is becoming a recommended treatment option but has limitations due to its heterogeneous laser parameters. Here, we report on our successful clinical experience on the use of class IV laser therapy to treat OM induced by different chemotherapy regimens. To shed light on the mechanisms of action of laser therapy in improving OM resolution, we have developed an animal model of chemotherapy-induced OM, in which we compare the efficacy of the standard low-power laser therapy protocol with an innovative protocol, defined as high-power laser therapy. We show that high-power laser therapy is more effective than low-power laser therapy in improving OM lesion healing, reducing the inflammatory burden, and preserving tissue integrity. In addition, high-power laser therapy has been particularly effective in promoting the formation of new arterioles within the granulation tissue. Our results provide important insights into the mechanism of action of biostimulating laser therapy on OM in vivo and pave a way for clinical experimentation with the use of high-power laser therapy.

UR - http://www.scopus.com/inward/record.url?scp=84888217027&partnerID=8YFLogxK

U2 - 10.1016/j.ajpath.2013.09.003

DO - 10.1016/j.ajpath.2013.09.003

M3 - Article

C2 - 24096076

AN - SCOPUS:84888217027

SN - 0002-9440

VL - 183

SP - 1747

EP - 1757

JO - American Journal of Pathology

JF - American Journal of Pathology

IS - 6

ER -

Effect of class IV laser therapy on chemotherapy-induced oral mucositis: A clinical and experimental study

Abstract

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this