Effect of COMT genotype on aggressive behaviour in a community cohort of schizophrenic patients

Sarah Tosato; Chiara Bonetto; Marta Di Forti; David Collier; Doriana Cristofalo; Mariaelena Bertani; Martina Zanoni; Giovanna Marrella; Lorenza Lazzarotto; Antonio Lasalvia; Marzia De Gironcoli; Michele Tansella; Paola Dazzan; Robin Murray; Mirella Ruggeri

doi:10.1016/j.neulet.2011.03.018

Effect of COMT genotype on aggressive behaviour in a community cohort of schizophrenic patients

Sarah Tosato, Chiara Bonetto, Marta Di Forti, David Collier, Doriana Cristofalo, Mariaelena Bertani, Martina Zanoni, Giovanna Marrella, Lorenza Lazzarotto, Antonio Lasalvia, Marzia De Gironcoli, Michele Tansella, Paola Dazzan, Robin Murray, Mirella Ruggeri

Research output: Contribution to journal › Article › peer-review

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Abstract

Although the etiology of aggression is multifactorial, many studies have associated the Val158Met polymorphism of the COMT with aggression in schizophrenia. This study tests the hypothesis that Met/Met patients display more episodes of aggression and violent behaviour than Val/Val patients in a 6 year follow-up cohort of subjects with schizophrenia in contact with the South-Verona Community-based Mental Health Service. Out of the 141 subjects with an ICD-10 SCAN-confirmed diagnosis of schizophrenia, 115 completed both baseline and follow-up assessments (81.6% of the baseline cohort). Of these, 80 subjects (70%) were genotyped and rated for aggression using the Overt Aggression Scale. Met/Met homozygous patients had higher aggressive behaviour compared to Val/Val homozygous subjects. Antipsychotic dosage, alcohol and drug abuse were taken into account as confounders. The Met/Met genotype of COMT may have an effect on aggressive behaviour in schizophrenia because norepinephrine is less effectively inactivated. (C) 2011 Elsevier Ireland Ltd. All rights reserved.

Original language	English
Pages (from-to)	17 - 21
Number of pages	5
Journal	Neuroscience Letters
Volume	495
Issue number	1
DOIs	https://doi.org/10.1016/j.neulet.2011.03.018
Publication status	Published - 9 May 2011

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Tosato, S., Bonetto, C., Di Forti, M., Collier, D., Cristofalo, D., Bertani, M., Zanoni, M., Marrella, G., Lazzarotto, L., Lasalvia, A., De Gironcoli, M., Tansella, M., Dazzan, P., Murray, R., & Ruggeri, M. (2011). Effect of COMT genotype on aggressive behaviour in a community cohort of schizophrenic patients. Neuroscience Letters, 495(1), 17 - 21. https://doi.org/10.1016/j.neulet.2011.03.018

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title = "Effect of COMT genotype on aggressive behaviour in a community cohort of schizophrenic patients",

abstract = "Although the etiology of aggression is multifactorial, many studies have associated the Val158Met polymorphism of the COMT with aggression in schizophrenia. This study tests the hypothesis that Met/Met patients display more episodes of aggression and violent behaviour than Val/Val patients in a 6 year follow-up cohort of subjects with schizophrenia in contact with the South-Verona Community-based Mental Health Service. Out of the 141 subjects with an ICD-10 SCAN-confirmed diagnosis of schizophrenia, 115 completed both baseline and follow-up assessments (81.6% of the baseline cohort). Of these, 80 subjects (70%) were genotyped and rated for aggression using the Overt Aggression Scale. Met/Met homozygous patients had higher aggressive behaviour compared to Val/Val homozygous subjects. Antipsychotic dosage, alcohol and drug abuse were taken into account as confounders. The Met/Met genotype of COMT may have an effect on aggressive behaviour in schizophrenia because norepinephrine is less effectively inactivated. (C) 2011 Elsevier Ireland Ltd. All rights reserved.",

author = "Sarah Tosato and Chiara Bonetto and {Di Forti}, Marta and David Collier and Doriana Cristofalo and Mariaelena Bertani and Martina Zanoni and Giovanna Marrella and Lorenza Lazzarotto and Antonio Lasalvia and {De Gironcoli}, Marzia and Michele Tansella and Paola Dazzan and Robin Murray and Mirella Ruggeri",

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Tosato, S, Bonetto, C, Di Forti, M , Collier, D, Cristofalo, D, Bertani, M, Zanoni, M, Marrella, G, Lazzarotto, L, Lasalvia, A, De Gironcoli, M, Tansella, M, Dazzan, P , Murray, R & Ruggeri, M 2011, 'Effect of COMT genotype on aggressive behaviour in a community cohort of schizophrenic patients', Neuroscience Letters, vol. 495, no. 1, pp. 17 - 21. https://doi.org/10.1016/j.neulet.2011.03.018

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T1 - Effect of COMT genotype on aggressive behaviour in a community cohort of schizophrenic patients

AU - Tosato, Sarah

AU - Bonetto, Chiara

AU - Di Forti, Marta

AU - Collier, David

AU - Cristofalo, Doriana

AU - Bertani, Mariaelena

AU - Zanoni, Martina

AU - Marrella, Giovanna

AU - Lazzarotto, Lorenza

AU - Lasalvia, Antonio

AU - De Gironcoli, Marzia

AU - Tansella, Michele

AU - Dazzan, Paola

AU - Murray, Robin

AU - Ruggeri, Mirella

PY - 2011/5/9

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N2 - Although the etiology of aggression is multifactorial, many studies have associated the Val158Met polymorphism of the COMT with aggression in schizophrenia. This study tests the hypothesis that Met/Met patients display more episodes of aggression and violent behaviour than Val/Val patients in a 6 year follow-up cohort of subjects with schizophrenia in contact with the South-Verona Community-based Mental Health Service. Out of the 141 subjects with an ICD-10 SCAN-confirmed diagnosis of schizophrenia, 115 completed both baseline and follow-up assessments (81.6% of the baseline cohort). Of these, 80 subjects (70%) were genotyped and rated for aggression using the Overt Aggression Scale. Met/Met homozygous patients had higher aggressive behaviour compared to Val/Val homozygous subjects. Antipsychotic dosage, alcohol and drug abuse were taken into account as confounders. The Met/Met genotype of COMT may have an effect on aggressive behaviour in schizophrenia because norepinephrine is less effectively inactivated. (C) 2011 Elsevier Ireland Ltd. All rights reserved.

AB - Although the etiology of aggression is multifactorial, many studies have associated the Val158Met polymorphism of the COMT with aggression in schizophrenia. This study tests the hypothesis that Met/Met patients display more episodes of aggression and violent behaviour than Val/Val patients in a 6 year follow-up cohort of subjects with schizophrenia in contact with the South-Verona Community-based Mental Health Service. Out of the 141 subjects with an ICD-10 SCAN-confirmed diagnosis of schizophrenia, 115 completed both baseline and follow-up assessments (81.6% of the baseline cohort). Of these, 80 subjects (70%) were genotyped and rated for aggression using the Overt Aggression Scale. Met/Met homozygous patients had higher aggressive behaviour compared to Val/Val homozygous subjects. Antipsychotic dosage, alcohol and drug abuse were taken into account as confounders. The Met/Met genotype of COMT may have an effect on aggressive behaviour in schizophrenia because norepinephrine is less effectively inactivated. (C) 2011 Elsevier Ireland Ltd. All rights reserved.

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DO - 10.1016/j.neulet.2011.03.018

M3 - Article

VL - 495

SP - 17

EP - 21

JO - Neuroscience Letters

JF - Neuroscience Letters

IS - 1

ER -

Effect of COMT genotype on aggressive behaviour in a community cohort of schizophrenic patients

Abstract

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